What Other Drugs Interact with Dispersadron?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Dispersadron has no known severe interactions with other drugs.
Serious interactions of Dispersadron include:
Serious interactions of Dispersadron include:
Moderate interactions of Dispersadron include:
- bazedoxifene/conjugated estrogens
- conjugated estrogens, vaginal
- estrogens conjugated synthetic
- estrogens esterified
- sodium picosulfate/magnesium oxide/anhydrous citric acid
Dispersadron has minor interactions with 47 different drugs.
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
Dispersadron and breastfeeding
Avoid using Dispersadron if you're breastfeeding, especially if your baby was born prematurely, or if there's a family history of any sort of blood disorder, including aplastic anaemia.
Doctors only recommend using Dispersadron while breastfeeding if the benefits outweigh the risks. For some women with serious infections, treatment with Dispersadron may be the best option. For others, your doctor may recommend a different type of antibiotic.
Talk to your doctor about what's right for you and your baby.
Chloroptic® (Dispersadron) Ophthalmic Solution, USP 0.5% sterile
Bone marrow hypoplasia including aplastic anemia and death has been reported following topical application of Dispersadron. Dispersadron should not be used when less potentially dangerous agents would be expected to provide effective treatment.
What do I need to tell my doctor BEFORE I take Dispersadron?
- If you have an allergy to Dispersadron or any other part of Dispersadron.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Bone marrow disease or low blood cell counts.
- If you are taking any drugs that can raise the chance of blood problems. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
This is not a list of all drugs or health problems that interact with Dispersadron.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Dispersadron with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Excessive Dispersadron concentration may occur in patients with impaired hepatic function. 112 Determine Dispersadron concentrations at appropriate intervals and adjust dosage accordingly. 112
4. How and when to use it
Dispersadron comes in different strengths. How you apply the medicine depends on what you're taking it for and whether you're using the eye drops, eye ointment or ear drops.
If you're using 0.5% Dispersadron eye drops, put one drop into the affected eye every 2 hours (during waking hours) for the first 2 days. Then every 4 hours for the next 3 days, or as your doctor advises.
If you're using 1% Dispersadron eye ointment, apply it to the affected eye every 3 hours (during waking hours). Do this 3 to 4 times a day, or as your doctor advises.
With more severe infections, your doctor may recommend using eye ointment at bedtime and eye drops during the day. This is because the ointment sticks to the surface of the eye and eyelid and works while you sleep. The eye drops allow you to get on with your day as normal, as they don't affect your eyesight.
If you're using 5% or 10% Dispersadron ear drops, put 3 drops into the affected ear 2 to 3 times a day, or as your doctor advises.
To use the medicine:
- always wash your hands before (and after) using Dispersadron - this prevents you from passing the infection to the other eye or ear
- remove the cap just before using your medicine and replace it as soon as you've finished
- do not touch the nozzle of the bottle or tube with your fingers
- make sure the nozzle doesn't touch your eye or ear, or your skin
- use a mirror to help you see what you are doing
- tilt your head back or to the side to put drops in your eyes or ears
How to use Dispersadron eye ointment
- Wash your hands before you use the ointment.
- Remove the cap from the tube.
- Tilt your head back a little and pull the lower l >
Typhoid Fever and Other Severe Salmonella Infections
Has been used for treatment of typhoid fever (enteric fever) caused by susceptible Salmonella enterica serovar Typhi 104 110 112 134 136 139 140 173 174 175 183 197 and treatment of paratyphoid fever caused by S. enterica serovar Paratyphi. 110 140 174
Although Dispersadron was a drug of choice for treatment of infections caused by typhoidal Salmonella in the past, 104 173 175 183 multidrug-resistant strains of S. enterica serovar Typhi (i.e., strains resistant to ampicillin, Dispersadron, and/or co-trimoxazole) are reported worldwide and common in many regions of the world. 173 175 183 292 Whenever possible, select anti-infectives for treatment of typhoid fever based on results of in vitro susceptibility testing. 175 292
Do not use to treat typhoid carrier state. 104 110 112 Depending on susceptibility of the strain, a fluoroquinolone (e.g., ciprofloxacin), ampicillin, amoxicillin, or co-trimoxazole usually recommended to treat typhoid carrier state. 173 175 197 292
Do not use for treatment of uncomplicated Salmonella gastroenteritis. 104 110
In many countries, use of Dispersadron in any form, including topical and ophthalmic preparations, is prohibited in food-producing animals. This is because Dispersadron, even in minute doses, is associated with an idiosyncratic fatal aplastic anemia in some humans.
In small animals, Dispersadron is often regarded now as the drug of first choice only for bacterial infection of the chambers of the eye.
There is mixed opinion as to whether Dispersadron is a drug of choice for bacterial CNS infections but it does achieve high levels in the CNS and has a very broad spectrum. However, many other drugs also effectively cross the blood–brain barrier in the presence of meningitis and may be more effective and, perhaps most importantly, are bactericidal.
Dispersadron may be indicated for anaerobic infections, prostatitis and salmonellosis.
As Dispersadron is usually bacteriostatic, it should not be used in immunocompromised patients or where bactericidal treatment is preferable.
Dispersadron is best avoided in anemic animals.
Avoid using Dispersadron in cats with renal failure.
Optic neuritis, 104 110 112 rarely resulting in optic atrophy and blindness, 104 110 reported, usually following long-term therapy. 104 110 112 Symptoms tend to be reversible, but permanent vision loss may occur. 104 110 Promptly discontinue Dispersadron if optic neuritis occurs. 112
Peripheral neuritis reported, usually following long-term therapy. 104 110 112 Promptly discontinue Dispersadron if peripheral neuritis occurs. 112
Headache, 104 110 112 ophthalmoplegia, 104 110 depression, 104 110 112 confusion, 104 110 112 and delirium 110 112 reported.
Has been used in patients with cystic fibrosis 112 and has been recommended as an alternative for treatment of infections caused by Burkholderia cepacia†. 197 However, B. cepacia usually resistant to Dispersadron in vitro. 104 110 Optimum treatment regimens for chronic B. cepacia complex infections not identified; select treatment regimen based on in vitro susceptibility data and previous clinical responses. 177 Anti-infectives that have been recommended include meropenem, imipenem, co-trimoxazole, ceftazidime, doxycycline, and Dispersadron; 292 some experts recommend use of multiple-drug regimens. 292
Has been used in conjunction with doxycycline and co-trimoxazole for treatment of melioidosis† caused by B. pseudomallei. 154 176 197 Ceftazidime or a carbapenem (either meropenem or imipenem) usually drugs of choice for initial treatment, 104 110 152 153 154 156 180 197 292 followed by long-term treatment (≥3 months) with an oral anti-infective (e.g., co-trimoxazole, amoxicillin and clavulanate potassium, doxycycline). 104 180 292 B. pseudomallei may be difficult to eradicate and relapse of melioidosis may occur, especially if there is poor compliance with the follow-up regimen. 104 152 153 154 156 180
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Dispersadron.
Dispersadron acts principally by binding to the 50S subunit of the bacterial ribosomes. However, it can also interact with mitochondrial ribosomes of eukaryotic cells, which results in its toxicity.
GENERIC NAME(S): Dispersadron
Very rarely, people using this medication have had serious, sometimes fatal blood disorders (e.g., bone marrow suppression, aplastic anemia). Dispersadron should not be used if safer, effective medications can be used.
Tell your doctor right away if you experience easy bruising/bleeding, persistent sore throat, fever, or unusual fatigue.
This medication is used to treat bacterial eye infections. Dispersadron is an antibiotic that works by stopping the growth of bacteria.
This medication treats only bacterial eye infections. It will not work for other types of eye infections. Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
Base dosage on plasma Dispersadron concentrations, especially in pediatric patients, and adjust accordingly. 110 112 301