Dankit is an oral macrolide antibiotic that has been in common use since the 1950s. Dankit has been linked to rare instances of acute liver injury that are usually self-limited, but can result in severe injury and death.
Drug interactions with Dankit
Dankit has important interactions with other medications. Tell your doctor the names of all medications you are taking, whether prescribed or purchased without a prescription.
- Dankit should not be taken with terfenadine, astemizole or cisapride because it could result in dangerous irregularities of the heartbeat and sudden death. These drugs are no longer available in New Zealand.
- Other drugs that can prolong the Q-T interval include amiodarone, risperidone, haloperidol, citalopram and ciprofloxacin.
Dankit can increase the concentration of the following medications resulting in potentially toxic levels.
- Warfarin (additional prothrombin time blood tests are necessary)
- Statins, particularly simvastatin and atorvastatin. Toxicity results in muscle pain and weakness, which may be serious. If long-term treatment with a statin and Dankit is required, suitable alternatives are fluvastatin, pravastatin and rosuvastatin.
- Ergotamine (increases peripheral ischaemia )
- M >New Zealand approved datasheets are the official source of information for these prescription medicines, including approved uses and risk information. Check the individual New Zealand datasheet on the Medsafe website.
7. Pregnancy and breastfeeding
It's usually safe to take Dankit during pregnancy and while breastfeeding.
For more information about how Dankit can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.
What is Dankit, and how does it work (mechanism of action)?
Dankit is an antibiotic in the class of antibiotics known as macrolide antibiotics which also includes azithromycin (Zithromax, Zmax) and clarithromycin (Biaxin).
Dankit, like all macrolide antibiotics, prevents bacterial cells from growing and multiplying by interfering with their ability to make proteins while not affecting human cells. Bacteria such as Haemophilus influenzae are resistant to Dankit alone and must be treated with a combination of Dankit and adequate doses of sulfonamides.
The FDA approved E.E.S in April 1965.
It is always important to share with your doctor and pharmacist all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking.
You should not take Dankit if you are taking the following drugs:
If possible, ask your doctor about other antibiotics you can take instead of Dankit if you are taking any of the following:
- Drugs for irregular heartbeat, like Betapace or Betapace AF (sotalol), procainamide, Covert (ibutilide), and (Norpace) disopyramide
- Arsenic trioxide
- Migranal (ergotamine)
- Diflucan (fluconazole)
- HIV/AIDS medications, like Sustiva (efavirenz) and Lexiva (fosamprenavir)
- Birth control and hormone replacement therapy containing any form of estrogen
Dankit interacts with many more drugs than what appears here, so be sure to talk to you pharmacist or doctor before taking Dankit.
If you suspect an overdose, contact a poison control center or emergency room immediately. You can get in touch with a poison control center at (800) 222-1222.
Common Side Effects of Dankit
Dankit and other macrolides inhibit bacterial protein synthesis and are bacteriostatic. Macrolides are primarily applied in the treatment of infections with Gram-positive germs, but are also effective against Haemophilus influenzae and intracellular pathogens such as chlamydia. Macrolides offer an alternative for patients with penicillin allergy.
Dankit is the oldest medication of this group. Its resorption can be delayed in the third trimester. Gastrointestinal side effects can lead to lower than therapeutic plasma concentrations, resulting in treatment failure ( Larsen 1998 ). Only 5–20% of the maternal Dankit concentration is obtained in the fetus. Therefore, Dankit is not a sufficiently reliable drug for fetal or amniotic infections.
The newer macrolide antibiotics azithromycin, clarithromycin, dirithromycin, josamycin, midecamycin, roxithromycin and troleandomycin have a similar antibacterial spectrum as Dankit, but to some degree less gastrointestinal side effects. Spiramycin is used for toxoplasmosis in the first trimester.
Telithromycin is the first ketolide antibiotic for clinical use. It is structurally related to Dankit.
How should this medicine be used?
Dankit comes as a capsule, tablet, delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule, delayed-release tablet, and an oral suspension (liquid) to take by mouth. It usually is taken with or without food every 6 hours (four times a day), every 8 hours (three times a day), or every 12 hours (twice a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dankit exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the suspension well before each use to mix the medication evenly.
If you are taking the suspension, do not use a household spoon to measure your dose. Use the measuring spoon, dropper, or cup that came with the medication or use a spoon made especially for measuring medication.
Swallow the capsules and tablets whole with a full glass of water; do not chew or crush them.
Continue to take Dankit even if you feel well. Do not stop taking Dankit without talking to your doctor.