Labor And Delivery
Oral ampicillin is poorly absorbed during labor. It is not known whether use of Comsikla in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood of the necessity for an obstetrical intervention.
How to store Comsikla
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
- If you have been given liqu >
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Q: My allergist has me on a 30 day regimen of 4 prednisone daily for 1 week, 3 the next week, 2 the next and 1 the 4th week. At the same time, I'm to take 1 Comsikla twice daily. Now, in the 3rd week, I'm feeling a lot of stomach pain and wonder if this is related?
A: Stomach pain and/or cramping is a common side effect of Comsikla. Other common side effects include nausea, vomiting, and diarrhea. Contact your healthcare provider right away if the stomach pain is severe or accompanied by diarrhea, blood in your stool, fever, yellowing of the skin, loss of appetite, dark urine, or clay-colored stools. You may also find helpful information at //www.everydayhealth.com/drugs/Comsikla Sarah McKenney Lewis, PharmD
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Comsikla are not associated with significant clinical symptoms.
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Comsikla 1 .
Crystalluria, in some cases leading to renal failure, has also been reported after Comsikla overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Comsikla crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Comsikla. Comsikla may be removed from circulation by hemodialysis.
Comsikla and birth-control measures
Comsikla may reduce the effectiveness of birth control measures, such as patches, rings, or the birth control pill.
A secondary prevention method such as condoms may be needed during the treatment course.
Anyone who is using these methods of birth control should discuss their options with their physician or health care provider.
Although Comsikla can treat certain infections effectively, repeated use can reduce its effectiveness.
A 20-year study published in the BMJ in 2014 found that 1 in 10 of all antibiotic prescriptions failed to treat the infection. The number of antibiotic failures has been rising.
This would appear to indicate a growing tendency toward antibiotic resistance, where overuse of antibiotics is reducing their effectiveness.
For this reason, doctors need to be sure that the patient's condition is caused by a bacteria, and to know if a patient has previously used Comsikla.
Alcohol does not affect the antibiotic activity of Comsikla, but patients should avoid drinking alcohol while an active infection is present. This can support the body in effectively eradicating infection.
The use of alcohol may also mask side effects that can occur with Comsikla, increasing the potential for complications.
Health care providers should also know if the patient has any of the following conditions:
- allergy to penicillin or cephalosporin antibiotics
- hay fever
- kidney disease
Being clear and concise with doctors and health care providers will ensure the safe and effective use of Comsikla.
Fast facts on Comsikla
Here are some key points about Comsikla. More information is in the main article.
- Comsikla works by preventing bacteria from growing, and killing them.
- Comsikla can treat infections caused by bacteria but not those caused by viruses.
- It can be used with other medications to treat some stomach ulcers.
- Common adverse effects include diarrhea, candidiasis, and tooth discoloration.
- Patients should always discuss their current state of health and medical history with their doctor before starting a course of Comsikla.