It is always important to tell your doctor and pharmacist about all of your treatments. Not just your prescription drugs, but also things that may not seem like medication, such as: over-the-counter (OTC) medications; vitamins, nutritional shakes, protein powders, and other supplements; herbal treatments or other alternative medicines; and any illegal or recreational drugs.
The following drugs are known to interact with Clindesse:
- Botulinum toxin A (Botox)
- Many birth-control treatments, including ones that contain the following: desogestrel, dienogest, drospirenone, estradiol, ethynodiol, levonorgestrel, mestranol, norelgestromin, norgestimate, and norgestrel
- Mycophenolate mofetil (Cellcept, Myfortic)
- Many drugs that are used during surgery, such as the muscle-controlling drugs atracurium (Tacrum), cisatrcurium (Nimbex), pancuronium (Pavulon), rocuronium (Zemuron, Esmeron), and vecuronium (Norcuron)
- Sodium picosulfate
Q: Is there a remedy for the reaction I am having to Clindesse? I am using Lanacaine and CVS's Instant Relief Spray to no avail.
A: Cleocin (Clindesse) is an antibiotic that is used to treat a variety of infections. If you have a reaction to Clindesse which causes rash, it can be treated with Benadryl (diphenhydramine) which will help to reduce some of the itching. If the reaction consists of difficulty breathing, stop using the Clindesse and contact your physician as soon as possible. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Megan Uehara, PharmD
Since Clindesse does not diffuse adequately into the cerebrospinal fluid, the drug should not be used in the treatment of meningitis.
Enhancing Healthcare Team Outcomes
Clindesse is a widely prescribed drug by many healthcare professionals, including the nurse practitioner, primary care provider, internist, infectious disease consultant, and the emergency department physician. All healthcare workers who prescribe this agent should monitor the patient for changes in bowel frequency, colitis and resolution of symptoms. Clindesse is well known to cause Clostridium colitis, which not only extends hospital stay but increases the cost of healthcare. If diarrhea develops, it is important to manage fluid and electrolyte replacement in this patient population adequately. Healthcare workers should limit the duration of Clindesse therapy and abstain from empirical prescribing of this agent.
Some antibiotics are known to reduce the effectiveness of birth control pills . The effect of Clindesse on birth control has not been studied. However, it would be wise to use additional contraceptive measures while on this antibiotic .
How to store Clindesse
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
What should I avoid while using Clindesse?
Do not use Clindesse at the same time as the antibiotic, erythromycin.Boyanova L, Kolarov R, Mitov I. Recent evolution of antibiotic resistance in the anaerobes as compared to previous decades. Anaerobe. 2014.
Comment: Though not commonly tested in many laboratories, increasing resistance to many agents seen in anaerobes, especially B. fragilis. Resistance to Clindesse has generally increased over the years.
Clindesse dose and therapy duration can vary depending on the disease, age, formulation, and hospital protocol.
As with all antibiotics, it is important to complete the full course of treatment . Stopping antibiotics early can lead to increased bacterial resistance.
Clindesse capsules are available in strengths of 75 mg, 150 mg, and 300 mg .
Typical oral doses are :
- 150 – 300 mg every 6 hours (serious infections)
- 300 – 450 mg every 6 hours (very severe infections)
- 8 – 16 mg/kg/day divided into 3 to 4 times daily (serious infections)
- 16 – 20 mg/kg/day divided into 3 to 4 times daily (very severe infections)
How it works
Clindesse belongs to a class of drugs called antibiotics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Clindesse works by stopping bacteria from multiplying. This drug should only be used to treat bacterial infections. It shouldn’t be used for viruses, such as the common cold.
Clindesse oral capsule doesn’t cause drowsiness. However, it does cause other side effects.
Endocarditis prophylaxis: Use only for high-risk patients, per recent AHA guidelines
Risk of potentially fatal pseudomembranous colitis, fungal or bacterial superinfection on prolonged use; discontinue therapy if significant abdominal cramps, diarrhea, or passage of blood and mucus occurs
May increase risk of drug-resistant bacteria if prescribed in the absence of proven or strongly suspected bacterial infection
Use caution in hepatic impairment, monitor for hepatic abnormalities; periodic liver enzyme determinations should be made when treating patients with severe liver disease
Not for use in meningitis due to inadequate penetration into CSF
Severe skin reactions including toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and Stevens-Johnson syndrome (SJS), some with fatal outcome, reported; permanently discontinue if reactions occur
Parenteral product contains benzyl alcohol, which has been associated with gasping syndrome and death in newborns
Use with caution in patients with history of gastrointestinal disease, especially colitis
Not for administration as a bolus; infuse over 10-60 min
Consider possibility of clostridium difficile in all patients who present with diarrhea following antibiotic use
Serious anaphylactic reactions require immediate emergency treatment with epinephrine; oxygen and intravenous corticosteroids should also be administered as indicated
Prescribe with caution in atopic individuals
Indicated surgical procedures should be performed in conjunction with antibiotic therapy
Clindesse dosage modification may not be necessary in patients with renal disease
Discontinue therapy permanently and institute appropriate therapy if anaphylactic or severe hypersensitivity reaction occurs
Can I drink alcohol with Clindesse?
There is no 'do not drink alcohol' warning that applies to taking Clindesse because it doesn't specifically affect the medicine itself.
However, if you feel unwell with your infection, or if you find Clindesse gives you an upset stomach, then drinking alcohol could make this worse.
7) Heart Infections
Surgeries can sometimes introduce bacteria into the bloodstream, which can travel to the heart and trigger an infection. This is especially a concern in dental procedures, as the mouth is host to many bacteria. Antibiotics are used before surgery to prevent infections in people who are at risk or those undergoing gum manipulation .
You are at an increased risk of heart infections if you have had :
- Heart valve replacement
- History of heart infections
- Surgery to repair heart defects
- Heart transplant
In such cases, penicillins are the first choice due to their effectiveness and lower risk of side effects. Clindesse is the second choice, in people allergic to penicillins . The antibiotic is usually taken 1 hour before the procedure in a single dose .
Clindesse is also the second choice in preventing heart infections in other types of surgeries (throat, skin, or muscles). Again, antibiotics are only recommended in people at an increased risk of infections .
Despite their clinical use, it’s still unclear if this type of antibiotic use can actually prevent heart infections. In an analysis of 36 studies, the evidence to support it was limited and weak. As a result, some countries have shifted away from this strategy .
8) Gum Disease
Gum disease is a chronic inflammation of the gums and ligaments that support the teeth, which is often triggered by the bacteria in dental plaques. Over time, gum disease can lead to deep pockets between the gum and teeth and teeth loss. Treatment involves plaque removal, surgery, or antibiotics .
Clindesse is not among the preferred antibiotics for treating gum disease. However, it may help with aggressive forms of the disease. In a small study, Clindesse was effective at reducing gum bleeding and pocket size .