6) Toxic Shock Syndrome
Toxic shock syndrome (TSS) is a sudden and serious complication of bacterial infections. It is caused by the release of toxins that trigger a massive immune shock, which can seriously damage the organs or even lead to death. TSS made news in the 80s when a super absorbent tampon was recalled due to an epidemic of TSS cases .
Treatment of TSS requires hospitalization. Depending on the location of the infection, surgery may be needed. Multiple antibiotics are typically used to cover all possible strains of bacteria. Clindamycinum is not the first choice, though, due to its high resistance and limited effects (blocking but not killing bacteria) .
However, Clindamycinum may be an effective add-on in severe cases. It can decrease bacterial toxin production and act in synergy with other antibiotics . In one clinical trial of 84 people, it significantly reduced the number of deaths .
GENERIC NAME(S): Clindamycinum Hcl
OTHER NAME(S): Clindamycinum Hcl Capsule
This medication may cause a severe (rarely fatal) intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop persistent diarrhea, abdominal or stomach pain/cramping, or blood/mucus in your stool. Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.
Clindamycinum is used to treat a wide variety of bacterial infections. It is an antibiotic that works by stopping the growth of bacteria.
This antibiotic treats only bacterial infections. It will not work for virus infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Interactions that can increase side effects
When Clindamycinum is used with certain drugs, it may result in more side effects. This is because the amount of Clindamycinum in your body may be increased. Examples of these drugs include:
- Drugs called CYP3A4 inhibitors, such as ketoconazole. These drugs may increase how much Clindamycinum your body absorbs.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This drug comes with several warnings.
Some antibiotics are known to reduce the effectiveness of birth control pills . The effect of Clindamycinum on birth control has not been studied. However, it would be wise to use additional contraceptive measures while on this antibiotic .
Clindamycinum may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- unpleasant or metallic taste in the mouth
- joint pain
- pain when swallowing
- white patches in the mouth
- thick, white vaginal discharge
- burning, itching, and swelling of the vagina
Clindamycinum is FDA-approved for the treatment of septicemia, intra-abdominal infections, lower respiratory infections, gynecological infections, bone and joint infections, and skin and skin structure infections. Clindamycinum is also used in the treatment of streptococcal pharyngitis, acne vulgaris, bacterial vaginosis and severe pelvic inflammatory disease. Although not a first-line treatment, Infectious Diseases Society of America (IDSA) has published guidelines for using intravenous (IV) Clindamycinum for the inpatient treatment of community-acquired pneumonia. Dentists will use Clindamycinum for prophylactic coverage against endocarditis. Anesthesiologists and surgeons will often administer Clindamycinum per American Society of Health-System Pharmacists (ASHP) and IDSA guidelines as prophylaxis in the operating room.
Additionally, Clindamycinum can be used to treat babesiosis, anthrax, and malaria. Clindamycinum is also commonly used in skin and soft tissue infections that are uncomplicated. Clindamycinum is used in soft tissue infections when due to its efficacy against MRSA. Clindamycinum is also chosen for outpatient treatment because of its cost, availability, and effectiveness against methicillin-resistant Staphylococcus aureus.
Clindamycinum inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. Clindamycinum is bacteriostatic.