Clindagel gel

Clindagel

  • Active Ingredient: Clindamycin
  • 300 mg, 150 mg
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What is Clindagel?

The active ingredient of Clindagel brand is clindamycin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside monohydrochloride.

Used for

Clindagel is used to treat diseases such as: Aspiration Pneumonia, Babesiosis, Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bacterial Vaginitis, Bone infection, Deep Neck Infection, Diverticulitis, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Malaria, Pelvic Inflammatory Disease, Peritonitis, Pneumocystis Pneumonia, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Toxoplasmosis, Toxoplasmosis, Prophylaxis.

Side Effect

Possible side effects of Clindagel include: confusion; hives or welts, itching, or skin rash; fever with or without chills; nausea or vomiting; blistering, peeling, or loosening of the skin.

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Pregnancy and Clindagel

Clindagel falls under the FDA's Pregnancy Category B, because it has not been shown to harm a fetus. Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

Clindagel is not recommended if you are breastfeeding. You should also alert your doctor before taking the drug if you are breastfeeding or plan to breastfeed.

Which drugs or supplements interact with oral Clindagel?

  • Clindagel may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium), which are used during surgery.

Adverse Effects

The adverse effects of Clindagel vary based on how it is administered. The most common side effects experienced with topical use include pruritis, xeroderma, erythema, burning, exfoliation, or oily skin. With intravaginal administration, the most common side effects are vaginal candidiasis, pruritis, vulvovaginal disease, and vulvovaginitis. The primary adverse effects of Clindagel with systemic administration are pseudomembranous colitis, nausea, vomiting, and diarrhea. This is a result of Clindagel destroying much of the GI tract’s normal flora. Clostridium difficile is given the opportunity to overgrow in this environment. Toxins A and B, which are produced by C. difficile, causes Clostridium difficile-associated diarrhea (CDAD). Severe cases which result from hypertoxic-producing strains result in an increase in morbidity and mortality which may require colectomy for definitive treatment. Other adverse effects include thrombophlebitis or metallic taste with IV administration, azotemia, agranulocytosis, anaphylactic shock, abscess formation, induration, or irritation at the site of IM injection.

What is Clindagel?

Clindagel is an antibiotic that fights bacteria in the body.

Clindagel is used to treat serious infections caused by bacteria.

Clindagel may also be used for purposes not listed in this medication guide.

Allergic reactions to Clindagel are rare. If you develop any kind of rash while taking Clindagel, contact your healthcare provider — this may be a sign of a drug allergy.

In rare cases, it’s possible to have a potentially life-threatening reaction called anaphylaxis.

Symptoms typically appear within 30 minutes of taking a drug and can include:

  • itchy hives and welts
  • swollen throat, which can cause wheezing and trouble with breathing or swallowing
  • chest tightness
  • abdominal cramps
  • vomiting
  • diarrhea
  • passing out
  • feelings of doom

While the risk of having an anaphylactic reaction to Clindagel is low, it’s important to know how to recognize the signs. Anaphylaxis is a medical emergency that requires immediate treatment.

Taking Clindagel can cause a range of side effects, including:

  • diarrhea
  • nausea or vomiting
  • loss of appetite

You can help to reduce nausea and vomiting by sticking with a simple, bland diet while taking Clindagel. Avoid spicy or rich foods that may irritate your stomach. Taking a probiotic, which may help to replenish beneficial bacteria in your gut, may also minimize side effects.

If you experience frequent, watery diarrhea while taking Clindagel, contact your healthcare provider before taking another dose. In rare cases, taking Clindagel can increase your risk of infection with Clostridium difficile.

C. diff happens when the balance of bacteria in your intestines is disrupted, such as during antibiotic treatment. This can cause the bacteria to grow out of control, which can potentially lead to a serious infection.

Symptoms of C. diff to watch for include:

  • watery diarrhea up to 15 times per day that may contain blood or pus
  • severe abdominal pain
  • low-grade fever
  • loss of appetite
  • nausea

Clindagel is safe for most people, including those who are pregnant or breastfeeding. If you’re breastfeeding, keep an eye out for any signs of diarrhea or diaper rash in your child.

Before taking Clindagel, make sure to tell your provider about any previous allergic reactions you’ve had to medications. Also tell them if you have a digestive or bowel condition that causes diarrhea.

Clindagel may interact with some other medications, so be sure to tell them if you’re also taking:

  • erythromycin
  • anti-diarrheal medications that contain the active ingredients loperam >

Not every tooth infection requires antibiotic treatment. If you do have a tooth infection that requires antibiotics and you’re allergic to penicillin or penicillin treatment hasn’t been effective, you may be prescribed Clindagel.

Your course of antibiotics should last about a week and you’ll typically have to take one or two pills every six hours. To prevent the infection from coming back, make sure to take the full dose of antibiotics as prescribed.

Pharmacokinetic studies in elderly volunteers (61-79 years) and younger adults (18-39 years) indicate that age alone does not alter Clindagel pharmacokinetics (clearance, elimination half-life, volume of distribution, and area under the serum concentration-time curve) after IV administration of Clindagel phosphate. After oral administration of Clindagel hydrochloride, elimination half-life is increased to approximately 4.0 hours (range 3.4-5.1 h) in the elderly compared to 3.2 hours (range 2.1 - 4.2 h) in younger adults. The extent of absorption, however, is not different between age groups and no dosage alteration is necessary for the elderly with normal hepatic function and normal (age-adjusted) renal function 1 .

6) Toxic Shock Syndrome

Toxic shock syndrome (TSS) is a sudden and serious complication of bacterial infections. It is caused by the release of toxins that trigger a massive immune shock, which can seriously damage the organs or even lead to death. TSS made news in the 80s when a super absorbent tampon was recalled due to an epidemic of TSS cases .

Treatment of TSS requires hospitalization. Depending on the location of the infection, surgery may be needed. Multiple antibiotics are typically used to cover all possible strains of bacteria. Clindagel is not the first choice, though, due to its high resistance and limited effects (blocking but not killing bacteria) .

However, Clindagel may be an effective add-on in severe cases. It can decrease bacterial toxin production and act in synergy with other antibiotics . In one clinical trial of 84 people, it significantly reduced the number of deaths .

Katlama C, De Wit S, O'Doherty E, et al. Pyrimethamine-Clindagel vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. Clin Infect Dis. 1996;22(2):268-75.

Comment: Pyrimethamine-Clindagel is less effective than sulfadiazine-pyrimethamine but can be used as an alternative treatment regimen in sulfa allergic pts.


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