Climadan capsules

Climadan

  • Active Ingredient: Clindamycin
  • 300 mg, 150 mg
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What is Climadan?

The active ingredient of Climadan brand is clindamycin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside monohydrochloride.

Used for

Climadan is used to treat diseases such as: Aspiration Pneumonia, Babesiosis, Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bacterial Vaginitis, Bone infection, Deep Neck Infection, Diverticulitis, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Malaria, Pelvic Inflammatory Disease, Peritonitis, Pneumocystis Pneumonia, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Toxoplasmosis, Toxoplasmosis, Prophylaxis.

Side Effect

Possible side effects of Climadan include: vomiting of blood; unpleasant breath odor; Cracks in the skin; headache; pain during sexual intercourse; confusion.

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Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Antibiotic-associated diarrhea. Symptoms can include:
    • severe diarrhea
    • bloody diarrhea
    • stomach cramping and pain
    • fever
    • dehydration
    • loss of appetite
    • weight loss
  • severe rash
  • peeling skin
  • swollen face or tongue
  • blisters on your skin or blisters in or around your nose, mouth, and eyes

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Climadan oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Is oral Climadan safe to take if I'm pregnant or breastfeeding?

  • The frequency of congenital abnormalities was not increased when pregnant women used Climadan during the second and third trimesters. Climadan should not be used during the first trimester of pregnancy unless it is clearly needed because it has not been properly evaluated during the first trimester of pregnancy.
  • Climadan is excreted in breast milk and should not be used by nursing mothers or nursing should be stopped.

Climadan Warnings

Climadan has a high-priority, FDA-issued warning about your risk of developing a dangerous, infectious and difficult-to-treat form of diarrhea.

Climadan changes the balance of microorganisms in your intestines, allowing growth of bacteria called Clostridium difficile (C. difficile). The bacteria produce toxins and inflammation that can cause diarrhea and damage your intestines.

After taking Climadan, diarrhea can take months to develop, and can range from mild to severe. Symptoms include frequent diarrhea with loose, watery stool that has an extremely foul smell.

People who take Climadan for long periods of time are at increased risk of developing C. difficile diarrhea. The infection is often picked up in hospitals or nursing homes, where there are also types of C. difficile that are resistant to treatment. Therefore, your doctor should only prescribe Climadan for serious infections that other drugs won't treat.

If you are allergic to Climadan or lincomycin, you should not take Climadan.

Tell your doctor if you are taking erythromycin, because Climadan and erythromycin should never be taken together.

Tell your doctor right away if you develop severe forms of any of the following symptoms that do not go away while taking Climadan:

  • Rash
  • Painful joints
  • Any problems swallowing, including pain while swallowing
  • Other mouth or throat symptoms, such as white spots, redness, or discomfort in your mouth area; a sore throat; or cracks in the corners of your lips (an infection called thrush)
  • Genital-area problems, such as burning, itching, creamy discharge, or swelling in your vagina; red rash, itching or burning on your penis
  • Nausea
  • Vomiting
  • Heartburn

Before taking Climadan, also let your doctor know if:

  • You are allergic to Climadan, lincomycin, or any of these drugs' ingredients
  • You have Crohn's disease, ulcerative colitis, any other type of colitis, or any condition that affects your intestines
  • You have meningitis

For anaerobic bacteria, the susceptibility to Climadan can be determined by a standardized test method 2,4 . The MIC values obtained should be interpreted according to the criteria provided in Table 1.

Table 1: Susceptibility Test Interpretive Criteria for Climadan

A report of Susceptible (S ) indicates that the antimicrobial drug is likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the site of infection. A report of Intermediate (I) indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone that prevents small, uncontrolled technical factors from causing major discrepancies in interpretation. A report of Resistant (R) indicates that the antimicrobial drug is not likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the infection site; other therapy should be selected.

What are the s >Medicines and their possible side effects can affect people in different ways. The following are some of the side effects that may be associated with Climadan. Just because a side effect is stated here doesn't mean that all people taking this antibiotic will experience that or any side effect.

Common side effects (affect between 1 in 10 and 1 in 100 people)

  • Stomach ache.
  • Diarrhoea. Stop taking Climadan and see your doctor straight away if you get diarrhoea either during treatment or in the few weeks after treatment.
  • Inflammation of the large intestine (colitis). Climadan alters the normal bacterial flora of the bowel, leading to overgrowth of a type of bacteria called Clostr >Other possible side effects

    Cautions

    Endocarditis prophylaxis: Use only for high-risk patients, per recent AHA guidelines

    Risk of potentially fatal pseudomembranous colitis, fungal or bacterial superinfection on prolonged use; discontinue therapy if significant abdominal cramps, diarrhea, or passage of blood and mucus occurs

    May increase risk of drug-resistant bacteria if prescribed in the absence of proven or strongly suspected bacterial infection

    Use caution in hepatic impairment, monitor for hepatic abnormalities; periodic liver enzyme determinations should be made when treating patients with severe liver disease

    Not for use in meningitis due to inadequate penetration into CSF

    Severe skin reactions including toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and Stevens-Johnson syndrome (SJS), some with fatal outcome, reported; permanently discontinue if reactions occur

    Parenteral product contains benzyl alcohol, which has been associated with gasping syndrome and death in newborns

    Use with caution in patients with history of gastrointestinal disease, especially colitis

    Not for administration as a bolus; infuse over 10-60 min

    Consider possibility of clostridium difficile in all patients who present with diarrhea following antibiotic use

    Serious anaphylactic reactions require immediate emergency treatment with epinephrine; oxygen and intravenous corticosteroids should also be administered as indicated

    Prescribe with caution in atopic individuals

    Indicated surgical procedures should be performed in conjunction with antibiotic therapy

    Climadan dosage modification may not be necessary in patients with renal disease

    Discontinue therapy permanently and institute appropriate therapy if anaphylactic or severe hypersensitivity reaction occurs

    Katlama C, De Wit S, O'Doherty E, et al. Pyrimethamine-Climadan vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. Clin Infect Dis. 1996;22(2):268-75.

    Comment: Pyrimethamine-Climadan is less effective than sulfadiazine-pyrimethamine but can be used as an alternative treatment regimen in sulfa allergic pts.

    Common Side Effects of Climadan

    Tell your doctor or seek immediate medical help if any of the following common side effects of Climadan do not go away or become severe:

    • Mild rash or itching
    • Stomach pain, nausea

    Climadan is an antibiotic which is given to treat serious bacterial infections. It is useful for treating joint and bone infections (such as osteomyelitis), and infections in the abdomen. It is also used to treat tooth infections where other antibiotics have not worked. It works by stopping the bacteria which are the cause of the infection from multiplying.

    Pneumococci

    Serious respiratory tract infections.

    Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to Climadan.

    To reduce the development of drug-resistant bacteria and maintain the effectiveness of CLEOCIN HCl and other antibacterial drugs, CLEOCIN HCl should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

    Q: How are the side effects of Climadan treated?

    A: Climadan is an antibiotic that is used to treat serious infections caused by bacteria. Common side effects of Climadan include changes in bowel habits, nausea, vomiting, stomach pain, joint pain, rash, and itching. Climadan can also cause a more serious side effect called pseudomembranous colitis, which is an infection of the large intestine that can range in severity from mild to life-threatening. Patients who develop diarrhea while taking Climadan or any other antibiotic should be evaluated by their healthcare provider for appropriate treatment. It is also important to understand that although you may feel better quickly, Climadan should be taken as directed for as long as directed. Skipping doses or not completing the full course of therapy may not fully treat the infection and it could come back and be harder to treat. Michelle McDermott, PharmD

    Adverse Effects

    The adverse effects of Climadan vary based on how it is administered. The most common side effects experienced with topical use include pruritis, xeroderma, erythema, burning, exfoliation, or oily skin. With intravaginal administration, the most common side effects are vaginal candidiasis, pruritis, vulvovaginal disease, and vulvovaginitis. The primary adverse effects of Climadan with systemic administration are pseudomembranous colitis, nausea, vomiting, and diarrhea. This is a result of Climadan destroying much of the GI tract’s normal flora. Clostridium difficile is given the opportunity to overgrow in this environment. Toxins A and B, which are produced by C. difficile, causes Clostridium difficile-associated diarrhea (CDAD). Severe cases which result from hypertoxic-producing strains result in an increase in morbidity and mortality which may require colectomy for definitive treatment. Other adverse effects include thrombophlebitis or metallic taste with IV administration, azotemia, agranulocytosis, anaphylactic shock, abscess formation, induration, or irritation at the site of IM injection.


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