Clidacin dose and therapy duration can vary depending on the disease, age, formulation, and hospital protocol.
As with all antibiotics, it is important to complete the full course of treatment . Stopping antibiotics early can lead to increased bacterial resistance.
Clidacin capsules are available in strengths of 75 mg, 150 mg, and 300 mg .
Typical oral doses are :
- 150 – 300 mg every 6 hours (serious infections)
- 300 – 450 mg every 6 hours (very severe infections)
- 8 – 16 mg/kg/day divided into 3 to 4 times daily (serious infections)
- 16 – 20 mg/kg/day divided into 3 to 4 times daily (very severe infections)
7) Heart Infections
Surgeries can sometimes introduce bacteria into the bloodstream, which can travel to the heart and trigger an infection. This is especially a concern in dental procedures, as the mouth is host to many bacteria. Antibiotics are used before surgery to prevent infections in people who are at risk or those undergoing gum manipulation .
You are at an increased risk of heart infections if you have had :
- Heart valve replacement
- History of heart infections
- Surgery to repair heart defects
- Heart transplant
In such cases, penicillins are the first choice due to their effectiveness and lower risk of side effects. Clidacin is the second choice, in people allergic to penicillins . The antibiotic is usually taken 1 hour before the procedure in a single dose .
Clidacin is also the second choice in preventing heart infections in other types of surgeries (throat, skin, or muscles). Again, antibiotics are only recommended in people at an increased risk of infections .
Despite their clinical use, it’s still unclear if this type of antibiotic use can actually prevent heart infections. In an analysis of 36 studies, the evidence to support it was limited and weak. As a result, some countries have shifted away from this strategy .
Clidacin side effects
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using Clidacin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Get emergency medical help if you have any signs of an allergic reaction to Clidacin: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have symptoms of a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Clidacin.
Clidacin can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. If you have diarrhea that is watery or bloody, stop using Clidacin and call your doctor.
Call your doctor at once if you have:
any change in bowel habits;
severe stomach pain, diarrhea that is watery or bloody;
little or no urination; or
a metallic taste in your mouth (after Clidacin injection).
Common Clidacin side effects may include:
nausea, vomiting, stomach pain;
mild skin rash; or
vaginal itching or discharge;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Clidacin for Acne
Clidacin can be applied to the skin to treat acne. It comes in lotion, cream, or gel form under the name Cleocin T or Clidacin phosphate.
For the best results, wait 30 minutes after washing your face or affected area before applying Clidacin to the skin. Your skin may become a little sensitive while using Clidacin, so be sure to use gentle cleansers and moisturizers that will not irritate it further.
Serious respiratory tract infections.
Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to Clidacin.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of CLEOCIN HCl and other antibacterial drugs, CLEOCIN HCl should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
What is oral Clidacin, and how does it work (mechanism of action)?
- Clidacin is an antibiotic used for treating serious infections. It is effective again several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins.
- The FDA approved Clidacin in February 1970.
In clinical trials with pregnant women, systemic administration of Clidacin during the second and third trimesters, has not been associated with increased frequency of congenital abnormalities
Clidacin should be used during first trimester of pregnancy only if clearly needed; there are no adequate and well-controlled studies in pregnant women during first trimester of pregnancy. Because animal reproduction studies are not always predictive of the human response, this drug should be used during pregnancy only if clearly needed
Can I take other medicines with Clidacin?
Before you take Clidacin, tell your doctor or pharmacist if you're already taking any medicines, including those bought without a prescription and herbal medicines. Similarly, always check with your doctor or pharmacist before taking any new medicines while you're taking Clidacin. Some key points are:
If you need to take a painkiller while you're taking Clidacin it's fine to take paracetamol or ibuprofen.
Clidacin doesn't affect hormonal contraceptives such as the pill. However, if you experience vomiting or diarrhoea while taking this antibiotic, this can potentially make your pill less effective at preventing pregnancy. If this happens to you, follow the instructions for vomiting and diarrhoea described in the leaflet provided with your pills.
Clidacin may rarely increase the anti-blood-clotting effects of warfarin. If you're taking warfarin your doctor may want to check your blood clotting time (INR) after you start and finish treatment with Clidacin.
Clidacin comes in 150 milligram (mg) and 300 mg capsules. You should receive no more than 4,800 mg of Clidacin in a day, and that dose is normally only for people receiving Clidacin via injection into the thigh.
You can take Clidacin with or without food, but always with a full glass of water to help prevent it from bothering your throat.
It's very important that you continue taking the medication as prescribed until you have finished it all, even if your symptoms improve and you start to feel better.Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52(3):e18-55.
Comment: IDSA guideline recommendations for the use of Clidacin in the treatment of MRSA infections.
Comment: Experimental study looking at linezolid, penicillin and Clidacin alone or in combination with respect to toxin suppression produced by Group A strep. Linezolid and Clidacin, alone or in combination with penicillin, increased toxin clearance.
Carcinogenesis, Mutagenesis, Impairment Of Fertility
Long-term studies in animals have not been performed with Clidacin to evaluate carcinogenic potential. Genotoxicity tests performed included a rat micronucleus test and an Ames Salmonella reversion test. Both tests were negative.
Fertility studies in rats treated orally with up to 300 mg/kg/day (approximately 1.6 times the highest recommended adult human dose based on mg/m²) revealed no effects on fertility or mating ability.
Clidacin has been shown to be active against most of the isolates of the following microorganisms, both in vitro and in clinical infections, as described in the INDICATIONS AND USAGE section.
Warnings for other groups
For pregnant women: Studies of pregnant women in their second and third trimesters have not shown any negative effects.
During the first trimester, this drug should only be used if clearly needed. Studies of the drug in pregnant animals during the first trimester haven’t shown a risk to the fetus. However, animal studies don’t always predict the way humans would respond. There haven’t been enough studies done in pregnant women during the first trimester to show if the drug poses a risk to a human pregnancy during that time.
Talk to your doctor if you’re pregnant or planning to become pregnant.
For women who are breastfeeding: Clidacin passes into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. Your doctor may suggest that you switch to a different medication.
For seniors: If you’re older than 65, you may not be able to tolerate the diarrhea this drug may cause. Your doctor may watch you more closely.
Clidacin (Cleocin) is an antibiotic prescribed to fight serious bacterial infections, for example, pneumonitis, lung abscess, ovarian abscess, endometritis, and serious skin and soft tissue infections. Review side effects, dosage, drug interactions, and pregnancy and breastfeeding safety information prior to taking this medication.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Antibiotic-associated diarrhea. Symptoms can include:
- severe diarrhea
- bloody diarrhea
- stomach cramping and pain
- loss of appetite
- weight loss
- severe rash
- peeling skin
- swollen face or tongue
- blisters on your skin or blisters in or around your nose, mouth, and eyes
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Clidacin oral capsule can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
How should I use Clidacin?
Take Clidacin exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Clidacin oral is taken by mouth. Clidacin injection is injected into a muscle, or as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Take the capsule with a full glass of water to keep it from irritating your throat.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
You may need frequent medical tests during treatment.
If you need surgery, let your surgeon know you use Clidacin as it may interact with certain drugs used for anesthesia.
Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Clidacin will not treat a viral infection such as the flu or a common cold.
Store at room temperature away from moisture and heat. Protect the injectable medicine from high heat.
Do not store the oral liquid in the refrigerator. Throw away any unused oral liquid after 2 weeks.