What should I avoid while giving Clavulin to my pet?
There are no restrictions on food or activity during treatment with Clavulin unless otherwise directed by your veterinarian.
Q: Can Clavulin cause hair loss?
A: Clavulin (Amoxil) is in a drug class called penicillin-type antibiotics. Clavulin works by stopping bacterial growth. According to the prescribing information, hair loss is not listed as a side effect associated with treatment with Clavulin. There can be many underlying factors that may lead to hair loss. Consult with your health care provider in regards to your symptoms for proper evaluation, diagnosis of the underlying cause and treatment options, if necessary. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kristen Dore, PharmD
By Chris Iliades, MD | Medically Reviewed by Farrokh Sohrabi, MD
Latest Update: 2014-04-28 Copyright © 2014 Everyday Health Media, LLC
Generic Name: Clavulin (am OX i sil in)Brand Names: Amoxil, Moxatag
Medically reviewed by Kaci Durbin, MD Last updated on Dec 11, 2018.
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Clavulin is sometimes used to get rid of Helicobacter pylori. This is an infection often found in people with stomach ulcers. If you are prescribed it for this reason, you will also be prescribed other medicines to take alongside it.
Serious side effects
Serious side effects are rare and happen in less than 1 in 1,000 people.
Call a doctor straight away if you get:
- diarrhoea (possibly with stomach cramps) that contains blood or mucus. If you have severe diarrhoea for more than 4 days you should also speak to a doctor
- pale poo with dark pee, yellowing of the skin or the whites of your eyes (warning signs of liver or gallbladder problems)
- bruising or skin discolouration
- joint or muscle pain that comes on after 2 days of taking the medicine
- a skin rash with circular red patches
Some of these serious side effects can happen up to 2 months after finishing the Clavulin.
Unusual bleeding or bruising
Bleeding under the skin can occur from broken blood vessels that form tiny pinpoint red dots (called petechiae). Blood can also collect under the tissue in larger flat areas (called purpura), or in a very large bruised area (called an ecchymosis).
Clavulin can increase the risk of bleeding. If you’re experiencing either unusual bleeding or bruising, see a doctor immediately. Internal bleeding may be occurring, which could lead to bleeding in the digestive system, or, in rare cases, the brain.
To prevent this, make sure your doctor knows if you’re on anticoagulants or blood thinners before you start taking Clavulin.
If you experience this side effect of Clavulin, it’s considered a rare but serious side effect. Seek medical attention as soon as possible.
Q: I've been trying to get pregnant. I just got off the shot and am taking Clavulin for my toothache. Does it increase my chance of getting pregnant?
A: There exists no clinical data or evidence that Clavulin can increase the chance of pregnancy. //www.everydayhealth.com/drugs/Clavulin. Lori Mendoza, PharmD
In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Clavulin are not associated with significant clinical symptoms.
Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Clavulin 1 .
Crystalluria, in some cases leading to renal failure, has also been reported after Clavulin overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Clavulin crystalluria.
Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Clavulin. Clavulin may be removed from circulation by hemodialysis.
1. About Clavulin
Clavulin is an antibiotic.
It's used in children, often to treat ear infections and chest infections.
The medicine is only available on prescription. It comes as capsules or as a liquid that you drink. It's also given by injection, but this is usually only done in hospital.
What other drugs will affect Clavulin?
Before giving Clavulin, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), allopurinol, or probenecid. You may not be able to give Clavulin or you may need to have the dosage adjusted. Drugs other than those listed here may also interact with Clavulin. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
Clavulin isn't suitable for some people. To make sure Clavulin is safe for you, tell your doctor if you:
- have had an allergic reaction to Clavulin or penicillin or any other medicines in the past
- have liver or kidney problems
- have recently had, or are about to have, any vaccinations
Q: How do you take Clavulin-potassium clavulanate?
A: Augmentin is an oral antibacterial combination consisting of the semisynthetic antibiotic Clavulin and the ?-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Clavulin is an analog of ampicillin. Augmentin is generally well tolerated. The side effects reported with Augmentin use were mild and transient in nature and less than 3% of patients discontinued therapy because of drug-related side effects. The most common side effects with Augmentin use include diarrhea/loose stools, nausea, skin rashes and urticaria, vomiting, and vaginitis. The overall incidence of side effects, and in particular diarrhea, increased with the higher recommended dose. Other less frequently reported reactions include: Abdominal discomfort, flatulence, and headache. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Augmentin and other antibacterial drugs, Augmentin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. The usual adult dose of Augmentin is one 500-mg tablet every 12 hours or one 250-mg tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 875-mg tablet of Augmentin every 12 hours or one 500-mg tablet of Augmentin every 8 hours. Augmentin may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when Augmentin is administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, Augmentin should be taken at the start of a meal.
Pregnancy Category B. Reproduction studies have been performed in mice and rats at doses up to 2000 mg/kg (3 and 6 times the 3 g human dose, based on body surface area). There was no evidence of harm to the fetus due to Clavulin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Clavulin should be used during pregnancy only if clearly needed.
More Clavulin resources and information
This list may not describe all the potential side effects of Clavulin. If you are experiencing any adverse effects of any drug that isn’t listed here, call your doctor for advice.
Formulations of AMOXIL contain Clavulin, a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many Gram-positive and Gram-negative microorganisms. Chemically, it is (2S,5,R,6,R)-6--3,3-dimethyl-7-oxo-4-thia-1-azabicycloheptane-2-carboxylic acid trihydrate. It may be represented structurally as:
The Clavulin molecular formula is C16H19N3O5S•3H2O, and the molecular weight is 419.45.
Capsules: Each capsule of AMOXIL, with royal blue opaque cap and pink opaque body, contains 250 mg or 500 mg Clavulin as the trihydrate. The cap and body of the 250-mg capsule are imprinted with the product name AMOXIL and 250; the cap and body of the 500-mg capsule are imprinted with AMOXIL and 500. Inactive ingredients: D&C Red No. 28, FD&C Blue No. 1, FD&C Red No. 40, gelatin, magnesium stearate, and titanium dioxide.
Tablets: Each tablet contains 500 mg or 875 mg Clavulin as the trihydrate. Each film-coated, capsule-shaped, pink tablet is debossed with AMOXIL centered over 500 or 875, respectively. The 875-mg tablet is scored on the reverse side. Inactive ingredients: Colloidal silicon dioxide, crospovidone, FD&C Red No. 30 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide.
Powder for Oral Suspension: Each 5 mL of reconstituted suspension contains 125 mg, 200 mg, 250 mg or 400 mg Clavulin as the trihydrate. Each 5 mL of the 125-mg reconstituted suspension contains 0.11 mEq (2.51 mg) of sodium. Each 5 mL of the 200-mg reconstituted suspension contains 0.15 mEq (3.39 mg) of sodium. Each 5 mL of the 250-mg reconstituted suspension contains 0.15 mEq (3.36 mg) of sodium; each 5 mL of the 400-mg reconstituted suspension contains 0.19 mEq (4.33 mg) of sodium. Inactive ingredients: FD&C Red No. 3, flavorings, silica gel, sodium benzoate, sodium citrate, sucrose, and xanthan gum.