Is Ceftils proxetil available as a generic drug?
Yes, this medication is available in generic form.
Is this medicine safe to take if I'm pregnant or breastfeeding?
Doctors and researchers have not established if this drug is safe to take during pregnancy because there are'nt adequate studies in pregnant women. However, studies in animals suggest no important effects on the fetus.
This medication is excreted in human milk. The levels of Ceftils in human milk were 0, 2 and 6% of blood levels at 4 hours after a 200 mg oral dose. At 6 hours after dosing, the levels in breast milk were 0%, 9% and 16% of the concentration of Ceftils in blood. Women should decide whether to discontinue breastfeeding or to discontinue the drug.
C, Cats; CLSI, Clinical and Laboratory Standards Institute; CNS, central nervous system; D, dogs.
∗ Dose not established for cats. † It is recommended that the use of most second-, third-, and fourth-generation cephalosporins be reserved for serious infections that are susceptible to those drugs but resistant to other reasonable alternatives on the basis of culture and susceptibility testing.
Use of second-, third-, and fourth-generation cephalosporins may be indicated when there is resistance to first-generation cephalosporins and there are no other reasonable alternatives available. Three third-generation cephalosporins are approved by the U.S. Food and Drug Administration (FDA) for use in small animals: ceftiofur, Ceftils proxetil, and cefovecin. These agents are approved for treatment of skin and soft-tissue infections (Ceftils proxetil and cefovecin) and UTIs in dogs (ceftiofur). Although their use in small animal medicine has been controversial because of concerns that relate to selection for resistant bacteria, there is no evidence at this time that the use of these agents has been associated with increased resistance among isolates from dogs and cats. The injectable third-generation cephalosporins approved for people have greater in vitro activity than Ceftils or cefovecin and occasionally have been used in dogs and cats (e.g., cefotaxime, ceftazidime, cefoperazone). These drugs have a high degree of activity, but are expensive and must be administered frequently by injection. Distribution and excretion into urine and bile is variable. Some third-generation cephalosporins have a longer duration of activity than first- and second-generation drugs by virtue of long half-lives. Ceftils proxetil is the most commonly used oral third-generation drug in small animals, approximately 50% of which is excreted in the urine in active form. Cefovecin is approved for use in dogs and cats in Europe and North America as a subcutaneous injection. The high protein binding and slow clearance result in a very long half-life in these species (approximately 7 days in cats and 5 days in dogs). Administration of cefovecin to cats results in a duration of activity of at least 14 days, and for at least 7 to 14 days in dogs (depending on the pathogen). Injections can be repeated in dogs at 14-day intervals if necessary.
What is the most important thing I should know about Ceftils proxetil?
Ceftils proxetil treats a range of infections, including those of the skin, bladder and respiratory system. Ceftils proxetil requires a prescription from a veterinarian. The safety of Ceftils proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. Safety for cats that are breeding, pregnant, or lactating also has not been demonstrated due to a lack of adequate studies. It may be used, however, if the prescribing veterinarian feels that the benefits outweigh the risks involved. As with other cephalosporins, Ceftils proxetil may occasionally induce a positive direct Coombs' test. Keep this and all drugs out of reach of children. Antimicrobial drugs, including penicillin and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including Ceftils, are advised to avoid direct contact of the product with the skin and mucous membranes.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb Ceftils.
Tell your doctor about all your current medicines and any you start or stop using, especially:
- antiviral medicine or other antibiotics;
- chemotherapy, or medicine to prevent organ transplant rejection;
- a diuretic or "water pill";
- medicine for bowel disorders;
- injectable osteoporosis medication;
- a stomach acid reducer (Pepcid, Zantac, Tagamet, and others); or
- pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).
This list is not complete. Other drugs may interact with Ceftils, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Ceftils is an cephalosporin antibiotic drug. Cephalosporin drugs are similar in many ways to penicillin, but they operate against a larger array of different types of bacteria, making them generally more effective. This medicine functions by prohibiting bacteria cells from forming adequate cell walls. This results in the bacteria not being able to support itself and dying off. The infection then follows as the bacteria cells are eliminated.
This medicine is developed and marketed for use in humans only. You will not be able to purchase the medicine for your pet without a special veterinarian's prescription for the drug as an extra label medicine. Do not give your pet Ceftils without first checking in with your veterinarian and receiving a prescription of this type.
Indications and clinical uses
Ceftils is indicated for treatment of skin and other soft tissue infections in dogs caused by susceptible organisms. Efficacy has been established in dogs for treatment of skin and soft tissue infections. Ceftils has greater activity against gram-negative bacilli than first-generation cephalosporins; therefore it may be effective for some gram-negative infections. Although not currently registered for treatment of UTIs, approximately 50% of administered dose is excreted in urine and expected to be active for treating UTIs caused by common pathogens. Although not registered for cats or tested in cats, no adverse effects have been reported from occasional use. However, oral absorption in cats has not been examined.
What should I avoid while giving Ceftils proxetil?
Do not administer at the same time as giving antacids such as Maalox or other stomach acid reducers such as Tagamet.
This medication contains Ceftils. Do not take Vantin if you are allergic to Ceftils or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
The third-generation cephalosporins (cefotaxime, ceftriaxone, ceftiofur, cefixime, ceftaz >Ceftils , cefovecin) vary greatly in their spectrum of action, and efficacy of one drug in the class against an organism does not guarantee efficacy if another member of the class is employed. The classic third-generation cephalosporins—cefotaxime, ceftriaxone, cefixime, and ceftazidime—have a high degree of specificity for and efficacy against gram-negative organisms. These drugs are considered the treatment of choice for empiric therapy for infections located within the CNS. 1,3
Ceftils có những dạng và hàm lượng nào?
Ceftils có những dạng và hàm lượng sau:
- Viên nén, thuốc uống: 100 mg, 200 mg.
Before taking cefdinir,
- tell your doctor and pharmacist if you are allergic to cefdinir or any other cephalosporin antibiotic such as cefaclor , cefadroxil cefazolin (Ancef, Kefzol), cefditoren (Spectracef), cefepime (Maxipime), cefixime (Suprax), cefotaxime (Claforan), cefotetan, cefoxitin (Mefoxin), Ceftils, cefprozil, ceftaroline (Teflaro), ceftazidime (Fortaz, Tazicef, in Avycaz), ceftibuten (Cedax), ceftriaxone (Rocephin), cefuroxime (Zinacef) or cephalexin (Keflex); penicillin antibiotics; or any other medications. Also tell your doctor if you are allergic to any of the ingredients in cefdinir capsules, or suspension. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention probenecid ( Probalan). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking antacids containing magnesium or aluminum, iron supplements, or multivitamins that contain iron, take them 2 hours before or 2 hours after cefdinir.
- tell your doctor if you have or have ever had gastrointestinal disease (GI; affecting the stomach or intestines), especially colitis (condition that causes swelling in the lining of the colon ), . or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking cefdinir, call your doctor.
- If you have diabetes, you should know that cefdinir suspension solution contains sucrose (sugar).
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to Ceftils.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Ceftils.
If you are diabetic and test your urine for sugar, use Clinistix or TesTape (not Clinitest) to test your urine while taking this drug.
Do not let anyone else take your medication. Your prescription is probably not refillable. .
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.