Botamycin-N lotion


  • Active Ingredient: Clindamycin
  • 300 mg, 150 mg
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What is Botamycin-N?

The active ingredient of Botamycin-N brand is clindamycin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside monohydrochloride.

Used for

Botamycin-N is used to treat diseases such as: Aspiration Pneumonia, Babesiosis, Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bacterial Vaginitis, Bone infection, Deep Neck Infection, Diverticulitis, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Malaria, Pelvic Inflammatory Disease, Peritonitis, Pneumocystis Pneumonia, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Toxoplasmosis, Toxoplasmosis, Prophylaxis.

Side Effect

Possible side effects of Botamycin-N include: sore throat; general feeling of tiredness or weakness; pain in the lower back or side; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; difficulty with swallowing; blood in the urine or stools; heart stops; bloating.

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4) Vaginal Infections

Bacterial vaginosis (BV) is caused by an overgrowth of certain bacteria in the vagina, which causes an imbalance of the normal flora. Symptoms may include increased vaginal discharge, fishy odor, and burning urination, but about 84% of women experience no symptoms at all .

About 21 million women in the US are affected by BV. Even after treatment, the infection comes back in 50% of women within a year. Although BV is not sexually transmitted, it can increase the risk of acquiring STIs (including HIV) .

The recommended treatment for BV is either metronidazole or Botamycin-N. Botamycin-N vaginal cream is preferred due to fewer s >, while vaginal suppositories are an alternative .

Clinical trials have found that Botamycin-N and metron >. One study of 101 women found that Botamycin-N had a cure rate of 86.2% .

Although BV can also lead to premature birth and late miscarriage, it’s still unclear if the risks of antibiotic treatment outweigh the benefits in pregnant women. One clinical trial of 409 women with BV found that Botamycin-N reduced premature births by 60%. However, the evidence is still inconclusive, according to a larger analysis of 21 trials and over 7,800 women .

If you suspect BV and are pregnant (or planning to conceive), consult your doctor to screen for infections and discuss the best treatment strategies .

Bradley JS, Byington CL, Shah SS, et al. The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis. 2011;53(7):e25-76.

Comment: IDSA/PIDS dosing recommendations for Botamycin-N for the treatment of CAP in children.

What is Botamycin-N used for?

Botamycin-N is an antibiotic that's taken by mouth or given by injection to treat serious bacterial infections. These include bone and joint infections such as osteomyelitis, skin and soft tissue infections (including those caused by MRSA), peritonitis and tooth abscesses. Botamycin-N is usually reserved for when other types of antibiotic haven't been effective, and for people who are allergic to penicillins.

Botamycin-N cream is used to treat a vaginal infection called bacterial vaginosis (see our page on Dalacin cream) and Botamycin-N liquid or gel is used to treat acne (see our pages on Dalacin T and Zindaclin).

Botamycin-N Side Effects

Some common side effects of Botamycin-N include :

  • Diarrhea
  • Rash
  • Nausea
  • Vomiting
  • Abdominal pain
  • Metallic taste
  • Yellowing of the skin and eyes

Some rare, but serious side effects include :

  • Inflammation of the colon
  • C. difficile-associated diarrhea
  • Severe allergic reactions
  • Severe skin reactions

Topical forms of Botamycin-N tend to have fewer side effects.

Before taking this medicine

You should not use this medicine if you are allergic to Botamycin-N or lincomycin.

To make sure Botamycin-N is safe for you, tell your doctor if you have ever had:

colitis, Crohn's disease, or other intestinal disorder;

eczema, or allergic skin reaction;

asthma or a severe allergic reaction to aspirin;

an allergy to yellow food dye.

Animal studies have not shown any harm during pregnancy, but in humans, it is not known whether Botamycin-N will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Botamycin-N does pass into breast milk and may cause side effects in the nursing baby. If you are breastfeeding while taking this medicine, call your doctor if your baby has diaper rash, redness or white patches in the mouth or throat, stomach discomfort, or diarrhea that is watery or bloody. Let your doctor know if you are breastfeeding before taking Botamycin-N.

Botamycin-N injection may contain an ingredient that can cause serious side effects or death in very young or premature babies. Do not give this medicine to a child without medical advice.

Botamycin-N and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking Botamycin-N.

Grapefruit juice decreases the body's ability to break down Botamycin-N, which could cause the drug to rise to dangerously high levels in your blood.

Getting the most from your treatment

  • Remember to keep any routine appointments with your doctor. This is so your progress can be monitored. If you are taking Botamycin-N for more than 10 days, your doctor will want you to have some blood tests to check that your kidneys and liver are working well.
  • Some people develop thrush (redness and itching in the mouth or vagina) after taking a course of antibiotics. If you think you have thrush, speak with your doctor or pharmacist for advice.
  • This antibiotic may stop the oral typhoid vaccine from working. If you are due to have any vaccinations, make sure the person treating you knows that you are taking this medicine.

Botamycin-N side effects

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using Botamycin-N and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Get emergency medical help if you have any signs of an allergic reaction to Botamycin-N: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have symptoms of a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Botamycin-N.

Botamycin-N can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. If you have diarrhea that is watery or bloody, stop using Botamycin-N and call your doctor.

Call your doctor at once if you have:

any change in bowel habits;

severe stomach pain, diarrhea that is watery or bloody;

little or no urination; or

a metallic taste in your mouth (after Botamycin-N injection).

Common Botamycin-N side effects may include:

nausea, vomiting, stomach pain;

mild skin rash; or

vaginal itching or discharge;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Botamycin-N may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • unpleasant or metallic taste in the mouth
  • joint pain
  • pain when swallowing
  • heartburn
  • white patches in the mouth
  • thick, white vaginal discharge
  • burning, itching, and swelling of the vagina

What are the uses for oral Botamycin-N?

  • Botamycin-N is used for treatment of serious infections caused by susceptible bacteria. It is most often used for treating penicillin-allergic patients or in other situations where penicillin or other alternative antibiotics cannot be used.
  • Serious respiratory tract infections (for example, empyema, pneumonitis, and lung abscess)
  • Serious skin and soft tissue infections
  • Female pelvic and genital tract infections (for example, endometritis); and ovarian abscess)

How to take Botamycin-N

  • Before you start taking Botamycin-N, read the manufacturer's printed information leaflet from ins >

Q: The doctor put me on Botamycin-N for 10 days in case of a bacterial infection. The blood work results are not back yet. I am also experiencing an allergic reaction on my face from something. He suspected a strep infection of the skin. I have never heard of this. Will this medication cure it?

A: Streptococcus (strep) is a bacterium often found in the throat, respiratory tract and on the skin. When streptococci get under the skin, they can foster a common skin disease known as impetigo. Impetigo starts out as a little red pin-sized rash resembling tiny pimples. The treatment for impetigo is usually penicillins, but Botamycin-N is generally used in patients who are allergic to the penicillin group of medications. This is a common choice for skin infections, and is usually dosed three times a day for 10 days. Here is some information on Botamycin-N and impetigo: // // Lori Poulin, PharmD


Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less well. When Botamycin-N is indicated in these patients, they should be carefully monitored for change in bowel frequency.

CLEOCIN HCl should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.

CLEOCIN HCl should be prescribed with caution in atopic individuals.

Indicated surgical procedures should be performed in conjunction with antibiotic therapy.

The use of CLEOCIN HCl occasionally results in overgrowth of nonsusceptible organisms—particularly yeasts. Should superinfections occur, appropriate measures should be taken as indicated by the clinical situation.

Botamycin-N dosage modification may not be necessary in patients with renal disease. In patients with moderate to severe liver disease, prolongation of Botamycin-N half-life has been found. However, it was postulated from studies that when given every eight hours, accumulation should rarely occur. Therefore, dosage modification in patients with liver disease may not be necessary. However, periodic liver enzyme determinations should be made when treating patients with severe liver disease.

The 75 mg and 150 mg capsules contain FD&C yellow no. 5 (tartrazine), which may cause allergic-type reactions (including bronchial asthma) in certain susceptible individuals. Although the overall incidence of FD&C yellow no. 5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity.

Prescribing CLEOCIN HCl in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

5) Pelvic Inflammatory Disease

Pelvic inflammatory disease (PID) is a bacterial infection of the upper genital tract in women (may include the uterus, fallopian tubes, and ovaries). It is usually caused by the spreading of sexually transmitted bacteria along the reproductive organs. PID often causes no symptoms, although some women experience abnormal vaginal bleeding, painful sex, and lower abdominal pain .

Early diagnosis and treatment are important since untreated PID can lead to permanent scarring, infertility, and chronic pelvic pain .

Botamycin-N is not the first choice for treating PID, but can be used as an add-on in some cases (abscesses in ovaries). In one clinical trial of 119 people, antibiotic therapy including Botamycin-N had a 75% cure rate .

If you have symptoms of PID or an STI, see your doctor for a pelvic exam, vaginal discharge, and cervical culture analysis, and/or urine tests.

Inflammation or ulceration of the foodpipe (oesophagus). Make sure you take each dose of Botamycin-N with a full glass of water to avo >Read the leaflet that comes with the medicine or talk to your doctor or pharmacist if you want any more information about the possible side effects of Botamycin-N. If you think you have experienced a side effect, did you know you can report it using the yellow card website?


Botamycin-N is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria.

Botamycin-N is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Its use should be reserved for penicillin-allergic patients or other patients for whom, in the judgment of the physician, a penicillin is inappropriate. Because of the risk of colitis, as described in the BOXED WARNING, before selecting Botamycin-N, the physician should consider the nature of the infection and the suitability of less toxic alternatives (e.g., erythromycin).

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