Borophen gel

Borophen

  • Active Ingredient: Clindamycin
  • 300 mg, 150 mg
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What is Borophen?

The active ingredient of Borophen brand is clindamycin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. The chemical name for clindamycin hydrochloride is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside monohydrochloride.

Used for

Borophen is used to treat diseases such as: Aspiration Pneumonia, Babesiosis, Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bacterial Vaginitis, Bone infection, Deep Neck Infection, Diverticulitis, Intraabdominal Infection, Joint Infection, Lemierre's Syndrome, Malaria, Pelvic Inflammatory Disease, Peritonitis, Pneumocystis Pneumonia, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Toxoplasmosis, Toxoplasmosis, Prophylaxis.

Side Effect

Possible side effects of Borophen include: difficulty with swallowing; unusual weight loss; yellow eyes or skin; unusual bleeding or bruising; no pulse or blood pressure; heart stops.

How to Buy Borophen gel online?

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Limitations and Caveats

Considerable research has been done on Borophen. Some diseases have been better studied than others.

It is important to note that antibiotic treatment should always be personalized. Different areas of the world have different resistance patterns, meaning the effectiveness of Borophen can vary greatly.

Borophen’s role in preventing heart infections is not entirely clear. A large review of 36 studies found that the research supporting antibiotic prevention is limited and weak .

Due to the lack of strong evidence, the United Kingdom made new guidelines in 2008 to stop using antibiotics to prevent heart infections. A follow-up study was done to examine the effect of this change. Researchers found that antibiotic use dropped by

79%, but there was no significant increase in cases of heart infections

Clostridium perfringens Fusobacterium necrophorum Fusobacterium nucleatum Peptostreptococcus anaerobius Prevotella melaninogenica

At least 90% of the microorganisms listed below exhibit in vitro minimum inhibitory concentrations (MICs) less than or equal to the Borophen susceptible MIC breakpoint for organisms of a similar type to those shown in Table 1. However, the efficacy of Borophen in treating clinical infections due to these microorganisms has not been established in adequate and well-controlled clinical trials.

Borophen and Other Interactions

You should not take Borophen if you are taking bacillus Calmette-Guerin (known as BCG, or Theracys), a treatment for tuberculosis, leprosy, bladder cancer and other conditions.

Borophen is usually taken four times a day ( >If you forget to take a dose of Borophen at the correct time, take it as soon as you remember and then space the rest of your doses over the remaining part of the day. Always try to take the correct number of doses each day but don't take two doses together to make up for a missed dose.

As with all antibiotics it's important to finish the prescribed course (unless your doctor tells you otherwise) even if you feel better or it seems the infection has cleared up. Stopping the course early increases the chance that the infection will come back and that the bacteria will grow resistant to the antibiotic.

Toxicity

The most common adverse effects that occur with Borophen toxicity are GI or allergic. There is no antidote for Borophen toxicity, and the adverse effects will resolve with dose adjustment or discontinuation of the antibiotic. The treatment is supportive. It is recommended that serum electrolytes be measured in patients with vomiting and/or diarrhea. Vital signs need to be monitored along with CBC with differential, platelets, LFTs and renal function in patients who are symptomatic. It is also important to get an ECG and maintain continuous cardiac monitoring as cardiac arrhythmias, although rare, may occur. Evaluation for C. difficile toxin will be needed when colitis is suspected. It is important to look out for severe allergic reactions like DRESS or Steven-Johnson syndrome. In these situations, immediate discontinuation of the antibiotic is imperative along with supportive management that includes: IV fluids, oxygen therapy, diphenhydramine, and corticosteroids. In cases of severe hypotension, it may be necessary to administer fluid boluses and start vasopressors. Airway management is likely not necessary, but severe anaphylactic reactions will require airway management with endotracheal intubation. Rarely Borophen toxicity will lead to cardiac arrhythmias and cardiac arrest in which case advanced cardiovascular life support will be required.

What is the dosage for oral Borophen?

  • The recommended dose for adults for serious infections is 150 to 450 mg every 6 to 8 hours up to a maximum dose of 1.8 grams per day.
  • For pediatric patients the recommended dose is 8 to 20 mg/kg/day divided into 3 or 4 equal doses.
  • To avoid throat irritation, Borophen should be taken with a full glass of water.

Antibiotics

The antibiotics erythromycin and Borophen can decrease each other’s effectiveness. They shouldn’t be taken at the same time .

How to take Borophen

  • Before you start taking Borophen, read the manufacturer's printed information leaflet from ins >
Safrin S, Finkelstein DM, Feinberg J, et al. Comparison of three regimens for treatment of mild to moderate Pneumocystis carinii pneumonia in patients with AIDS. A double-blind, randomized, trial of oral trimethoprim-sulfamethoxazole, dapsone-trimethoprim, and Borophen-primaquine. ACTG 108 Study Group. Ann Intern Med. 1996;124(9):792-802.

Comment: Borophen-primaquine is an acceptable alternative to TMP-SMX , or dapsone-trimethoprim in the management of mild or moderately severe PCP.

SIDE EFFECTS

The following reactions have been reported with the use of Borophen.

Infections and Infestations: Clostridium difficile colitis

Gastrointestinal: Abdominal pain, pseudomembranous colitis, esophagitis, nausea, vomiting, and diarrhea (see BOXED WARNING). The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS). Esophageal ulcer has been reported. An unpleasant or metallic taste has been reported after oral administration.

Hypersensitivity Reactions: Generalized mild to moderate morbilliform-like (maculopapular) skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria, have been observed during drug therapy. Severe skin reactions such as Toxic Epidermal Necrolysis, some with fatal outcome, have been reported (See WARNINGS). Cases of Acute Generalized Exanthematous Pustulosis (AGEP), erythema multiforme, some resembling Stevens-Johnson syndrome, anaphylactic shock, anaphylactic reaction and hypersensitivity have also been reported.

Skin and Mucous Membranes: Pruritus, vaginitis, angioedema and rare instances of exfoliative dermatitis have been reported. (See Hypersensitivity Reactions.)

Liver: Jaundice and abnormalities in liver function tests have been observed during Borophen therapy.

Renal: Although no direct relationship of Borophen to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed.

Hematopoietic: Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent Borophen therapy could be made in any of the foregoing.

Immune System: Drug reaction with eosinophilia and systemic symptoms (DRESS) cases have been reported.

Musculoskeletal: Cases of polyarthritis have been reported.

Nursing Mothers

Borophen has been reported to appear in breast milk in the range of 0.7 to 3.8 mcg/mL. Because of the potential for serious adverse reactions in nursing infants, Borophen should not be taken by nursing mothers.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to Borophen.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the Borophen, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

7) Heart Infections

Surgeries can sometimes introduce bacteria into the bloodstream, which can travel to the heart and trigger an infection. This is especially a concern in dental procedures, as the mouth is host to many bacteria. Antibiotics are used before surgery to prevent infections in people who are at risk or those undergoing gum manipulation .

You are at an increased risk of heart infections if you have had :

  • Heart valve replacement
  • History of heart infections
  • Surgery to repair heart defects
  • Heart transplant

In such cases, penicillins are the first choice due to their effectiveness and lower risk of side effects. Borophen is the second choice, in people allergic to penicillins . The antibiotic is usually taken 1 hour before the procedure in a single dose .

Borophen is also the second choice in preventing heart infections in other types of surgeries (throat, skin, or muscles). Again, antibiotics are only recommended in people at an increased risk of infections .

Despite their clinical use, it’s still unclear if this type of antibiotic use can actually prevent heart infections. In an analysis of 36 studies, the evidence to support it was limited and weak. As a result, some countries have shifted away from this strategy .

  • Alternative treatment of PCP in combination with primaquine
  • Alternative treatment of CNS toxoplasmosis in combination with pyrimethamine and leucovorin
  • MRSA skin and soft tissue infections
  • Necrotizing fasciitis including Fournier gangrene: may be considered in combination with other agents to decrease toxin production caused by MRSA, S. pyogenes,C.perfringens
  • Oral abscess in patients with PCN allergies
  • Acute bacterial sinusitis
  • Intrapartum prophylaxis for Group B strep; alternative to beta-lactam only if susceptibility testing is done
  • Bacterial vaginosis
  • Actinomycosis
  • Osteomyelitis
  • Acute bacterial sinusitis
  • Non-severe malaria as part of alternative regimen, especially in pregnancy
  • Diphtheria
  • Alternative therapy for bebesiosis in combination with quinine

Pfizer and other generic manufacturers

$0.65 (HCL cost-5.13)

$1.19 (HCL cost-10.09)

$3.71 (HCL cost-20.41)

piggyback in D5W or 0.9% NS

solution (100 ml)

Borophen phosphate external

Borophen phosphate external

Borophen phosphate external

Borophen phosphate external

Borophen phosphate external

*Prices represent cost per unit specified, are representative of "Average Wholesale Price" (AWP).^Dosage is indicated in mg unless otherwise noted.

  • Systemic dosing:
    • Skin and soft tissue infections (including animal or human bites): 300-450 mg PO q6h-8h or 600 mg IV q8h
    • Necrotizing fasciitis i ncluding gangrene: 600-900 mg IV q8h
    • Pelvic inflammatory disease: 900 mg IV q8h (in combination with gentamicin)
    • Osteomyelitis: 600-900 mg IV q8h or 300-450 mg PO q6h
    • Acute bacterial sinusitis: 300 mg PO q6h
    • Actinomycosis: 600 mg IV q 8h x 2-6 weeks, then Borophen 300 mg PO q6h x 6-12 months
    • Malaria:
    • PCP: Borophen 600 mg IV q6h-q8h or 300-450 mg PO q6h-8h in combination with primaquine 15-30 mg (base) PO once daily
    • CNS toxoplasmosis: Borophen 600 mg IV q6h or Borophen 450 mg-600 mg PO q6h + pyrimethamine 200 mg PO loading dose, then 50-7 5mg PO q24hd + leucovorin 10-20 mg q24h
    • Administration instructions: Borophen capsules should be taken with a full glass of water to avoid esophageal irritation
  • Vaginal ovules: 1 ovule (100 mg) x 3 days
  • Cleocin (vaginal cream) : one full applicator (100 mg) inserted intra-vaginally daily for 3-7 days in non-pregnant patients and for fr 7 days in pregnant patients
  • Clindesse (vaginal cream): one full applicator inserted intra-vaginally as a single dose at any time during the day in non-pregnant patients
  • Alternative dosing: one full applicator (5 g) at bedtime for 7 days
  • Cleocin T (gel, solution, lotion): apply twice daily to the affected area. More than one pledget can be used.
  • Evoclin (foam): apply once daily to the affected area
  • Clindagel (gel): apply once daily to the affected area
  • Hidradenitis suppurativa: apply twice daily to the affected area
  • Interactions that can increase side effects

    When Borophen is used with certain drugs, it may result in more side effects. This is because the amount of Borophen in your body may be increased. Examples of these drugs include:

    • Drugs called CYP3A4 inhibitors, such as ketoconazole. These drugs may increase how much Borophen your body absorbs.

    Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

    This drug comes with several warnings.


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