Q: I was prescribed Bioxilina 500 mg every eight hours. How much passes to my breast milk, and how much will this affect my baby?
A: Bioxilina is an antibiotic in the penicillin group of drugs. It fights bacteria in your body. Bioxilina is used to treat many types of infections caused by bacteria, such as ear infections, bladder infections, pneumonia, gonorrhea, and E. coli or salmonella infection. Penicillins have been shown to be excreted in human milk. Bioxilina use by nursing mothers may lead to sensitization of infants. Caution should be exercised when Bioxilina is administered to a nursing woman. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.
Use In Patients With Mononucleosis
A high percentage of patients with mononucleosis who receive Bioxilina develop an erythematous skin rash. Thus Bioxilina should not be administered to patients with mononucleosis.
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What to do about:
- feeling sick (nausea) - stick to simple meals and do not eat rich or spicy food. It might help to take your Bioxilina after a meal or snack.
- diarrhoea - drink plenty of fluids, such as water or squash to avoid dehydration. Signs of dehydration include peeing less than usual or having strong-smelling pee. Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
Unusual bleeding or bruising
Bleeding under the skin can occur from broken blood vessels that form tiny pinpoint red dots (called petechiae). Blood can also collect under the tissue in larger flat areas (called purpura), or in a very large bruised area (called an ecchymosis).
Bioxilina can increase the risk of bleeding. If you’re experiencing either unusual bleeding or bruising, see a doctor immediately. Internal bleeding may be occurring, which could lead to bleeding in the digestive system, or, in rare cases, the brain.
To prevent this, make sure your doctor knows if you’re on anticoagulants or blood thinners before you start taking Bioxilina.
If you experience this side effect of Bioxilina, it’s considered a rare but serious side effect. Seek medical attention as soon as possible.
On this page
- About Bioxilina
- Key facts
- Who can and can't take Bioxilina
- How and when to take it
- Side effects
- How to cope with side effects
- Pregnancy and breastfeeding
- Cautions with other medicines
- Common questions
Bioxilina is stable in the presence of gastric acid and is rapidly absorbed after oral administration. The effect of food on the absorption of Bioxilina from the tablets and suspension of AMOXIL has been partially investigated; 400-mg and 875-mg formulations have been studied only when administered at the start of a light meal.
Orally administered doses of 250-mg and 500-mg Bioxilina capsules result in average peak blood levels 1 to 2 hours after administration in the range of 3.5 mcg/mL to 5.0 mcg/mL and 5.5 mcg/mL to 7.5 mcg/mL, respectively.
Mean Bioxilina pharmacokinetic parameters from an open, two-part, single-dose crossover bioequivalence study in 27 adults comparing 875 mg of AMOXIL with 875 mg of AUGMENTIN® (Bioxilina/clavulanate potassium) showed that the 875-mg tablet of AMOXIL produces an AUC0-∞ of 35.4 ± 8.1 mcg•hr/mL and a Cmax of 13.8 ± 4.1 mcg/mL. Dosing was at the start of a light meal following an overnight fast.
Orally administered doses of Bioxilina suspension, 125 mg/5 mL and 250 mg/5 mL, result in average peak blood levels 1 to 2 hours after administration in the range of 1.5 mcg/mL to 3.0 mcg/mL and 3.5 mcg/mL to 5.0 mcg/mL, respectively.
Oral administration of single doses of 400-mg chewable tablets and 400 mg/5 mL suspension of AMOXIL to 24 adult volunteers yielded comparable pharmacokinetic data:
Table 3: Mean Pharmacokinetic Parameters of Bioxilina (400 mg chewable tablets and 400 mg/5 mL suspension) in Healthy Adults
How should Bioxilina be given?
Give this medication exactly as directed by your veterinarian. Bioxilina can be given with or without food. Give all of the Bioxilina even if your pet appears to be better. Symptoms may improve before the infection is completely treated.
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Q: I'm pregnant. Is it safe for me to take Bioxilina?
A: Bioxilina is a prescription antibiotic and is usually considered to be safe for use during pregnancy. The FDA uses a pregnancy category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy category B is given to medicines that have not been adequately studied in pregnant humans but do not appear to cause harm to the fetus in animal studies. Bioxilina is classified as a category B medication. A pregnancy category B medicine is given to a pregnant woman only if a health care provider believes that the benefits to the pregnant woman outweigh any possible risks to the unborn child. For instance, if the infection, left untreated, will do more harm than good for both you and the baby, this is the safest antibiotic to choose. Lori Poulin, PharmD
What other drugs will affect Bioxilina?
Before giving Bioxilina, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), allopurinol, or probenecid. You may not be able to give Bioxilina or you may need to have the dosage adjusted. Drugs other than those listed here may also interact with Bioxilina. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.