Bioracef tablets

Bioracef

  • Active Ingredient: Cefuroxime
  • 500 mg, 250 mg
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What is Bioracef?

The active ingredient of Bioracef brand is cefuroxime. Cefuroxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.

Used for

Bioracef is used to treat diseases such as: Bacterial Infection, Bladder Infection, Bone infection, Bronchitis, Epiglottitis, Gonococcal Infection, Disseminated, Gonococcal Infection, Uncomplicated, Impetigo, Joint Infection, Kidney Infections, Lyme Disease, Meningitis, Otitis Media, Peritonitis, Pneumonia, Sepsis, Sinusitis, Skin and Structure Infection, Skin or Soft Tissue Infection, Strep Throat, Surgical Prophylaxis, Tonsillitis/Pharyngitis, Upper Respiratory Tract Infection, Urinary Tract Infection, Wound Infection.

Side Effect

Possible side effects of Bioracef include: clay-colored stools; chest pain; nasal congestion; gas in the stomach; Back, leg, or stomach pains; pain during sexual intercourse.

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¿Qué otras drogas afectarán a Bioracef?

Dígale a su médico todas las medicinas que usa, y cualquiera que comience o deje de usar, especialmente:

  • probenecid (Benemid);
  • un anticoagulante como warfarin (Coumadin, Jantoven); o
  • un diurético o "pastilla para eliminar el agua."

Esta lista no está completa. Otras drogas pueden interactuar con Bioracef, incluyendo medicinas que se obtienen con o sin receta, vitaminas, y productos herbarios. No todas las interacciones posibles aparecen en esta guía del medicamento.

Can Bioracef cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Bioracef. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Standardized susceptibility test procedures require the use of laboratory controls to monitor and ensure the accuracy and precision of supplies and reagents used in the assay, and the techniques of the individual performing the test. 1,2,4 The QC ranges for MIC and disk diffusion testing using the 30-mcg disk are provided in Table 11. 3

Table 11: Acceptable Quality Control (QC) Ranges for Bioracef Axetil

WHAT IS Bioracef?

Bioracef is an antibiotic in a class of drugs called cephalosporins. This medicine fights bacteria in the body.

Bioracef is used to treat many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.

Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. The zone size provides an estimate of the susceptibility of bacteria to antimicrobial compounds. The zone size should be determined using a standardized test method.4 This procedure uses paper disks impregnated with 30 mcg Bioracef axetil to test the susceptibility of microorganisms to Bioracef axetil. The disk diffusion interpretive criteria are provided in Table 10. 3

Table 10: Susceptibility Test Interpretive Criteria for Bioracef Axetil

Susceptibility of staphylococci to Bioracef may be deduced from testing only penicillin and either cefoxitin or oxacillin.

Susceptibility of Streptococcus pyogenes may be deduced from testing penicillin. 3

A report of “Susceptible” indicates that the antimicrobial drug is likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration usually achievable at the site of infection. A report of “Intermediate” indicates that the result should be considered equivocal, and if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of drug can be used. This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of “Resistant” indicates that the antimicrobial drug is not likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentrations usually achievable at the infection site; other therapy should be selected.

Drug Interactions

Concomitant administration of probenecid with Bioracef axetil tablets increases the Bioracef area under the serum concentration versus time curve and maximum serum concentration by 50% and 21%, respectively.

Important: if you develop an itchy rash, or a swollen face or mouth, or have difficulty breathing, these can be signs that you are allergic to the antibiotic. Do not take any more Bioracef and speak with your doctor or go to your local accident and emergency department straightaway.

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist for further advice.

How to store Bioracef

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.
  • If you have been given liqu >

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Please tell your doctor if you have kidney disease, a gastrointestinal (digestive) disease such as colitis, or have an inherited protein metabolism disorder called phenylketonuria. You may not be able to take Bioracef, or you may require a dosage adjustment or special monitoring during treatment if you have either of the conditions listed above.

Do not take Bioracef at the same time as antacids (e.g., Tums®, Maalox®, Rolaids®, others) or other medications taken to reduce stomach acid such as cimetidine (Tagamet®, Tagamet HB®, others), famotidine (Pepcid®, Pepcid AC®, Pepcid RPD®, others), ranitidine (Zantac®, others), or nizatidine (Axid®, others) unless otherwise directed by your doctor. Antacids and stomach acid reducers may reduce the effects of Bioracef.

Certain brands of Bioracef suspension and Bioracef suspension sachets have aspartame (a source of phenylalanine) in them and should not be used by anyone with the inherited protein metabolism disorder called phenylketonuria. Talk to your doctor if you have phenylketonuria or have a family history of phenylketonuria.

Furthermore, do not take this medicine if you have ever had an allergic reaction to another cephalosporin or to a penicillin unless your doctor is aware of the allergy and monitors your therapy.

The Bioracef (Ceftin®) suspension contains sucrose. Individuals with diabetes may need to be aware of the sucrose contained in this suspension.

Additionally, Bioracef is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not, however, take Bioracef without first talking to your doctor if you are pregnant or could become pregnant during treatment.

So too, this medicine passes into breast milk and may affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

What should I do if I forget a dose?

Take the missed dose as soon as you remember, then try to evenly space the rest of the doses for that day until you can return to a normal schedule.

Do not take a double dose of this medication unless otherwise directed by your doctor.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking Bioracef and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, face, or tongue, hives, or a rash) rash, redness, or itching severe nausea vomiting or diarrhea mucous or blood in the stool unusual bleeding or bruising

Other, less serious side effects may also occur. Continue to take the medication and talk to your doctor if you experience

mild nausea diarrhea yeast infection of the mouth or vagina

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Store the tablets at room temperature away from moisture and heat. The suspension can be stored at room temperature or in the refrigerator. Do not freeze.

Remember to throw away any unused medication after 10 days and, if necessary, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, please call the local emergency services on 911.

For Healthcare Professionals

Applies to Bioracef: injectable powder for injection, intravenous solution, oral powder for reconstitution, oral tablet

What is Bioracef? What are the uses for Bioracef?

Bioracef is a semisynthetic cephalosporin antibiotic, chemically similar to penicillin. Cephalosporins stop or slow the growth of bacterial cells by preventing bacteria from forming the cell wall that surrounds each cell. The cell wall protects bacteria from the external environment and keeps the contents of the cell together. Without a cell wall, bacteria are not able to survive. Bioracef is effective against a wide variety of bacteria, such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, E. coli, N. gonorrhea, and many others. Bioracef is used to treat infections of the middle ear, sinuses, skin, tonsils, and throat, and to treat laryngitis, bronchitis, pneumonia, urinary tract infections, gonorrhea, COPD, and early Lyme disease. The FDA approved Bioracef in December 1987.

OVERDOSE

Overdosage of cephalosporins can cause cerebral irritation leading to convulsions or encephalopathy. Serum levels of Bioracef can be reduced by hemodialysis and peritoneal dialysis.

Dosage In Patients With Impaired Renal Function

A dosage interval adjustment is required for patients whose creatinine clearance is less than 30 mL/min, as listed in Table 4 below, because Bioracef is eliminated primarily by the kidney .

Table 4: Dosing in Adults with Renal Impairment Creatinine Clearance (mL/min) Recommended Dosage ≥30 No dosage adjustment 10 to

Drug/Laboratory Test Interactions

A false-positive reaction for glucose in the urine may occur with copper reduction tests (e.g., Benedict's or Fehling's solution), but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood/plasma glucose levels in patients receiving Bioracef axetil. The presence of Bioracef does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.

¿Cuál es la información más importante que debo saber sobre Bioracef?

Usted no debe usar esta medicina si es alérgico a Bioracef o antibióticos similares, como cefdinir (Omnicef), cefprozil (Cefzil), cephalexin (Keflex), y otros.

In Summary

Commonly reported side effects of Bioracef include: diarrhea. See below for a comprehensive list of adverse effects.

Cardiovascular

A 90-year-old man, with no history of coronary artery disease, diabetes mellitus, hypertension, or hyperlipidemia, was administered 750 mg Bioracef axetil IM for urinary tract infection. About 10 minutes after the injection, the patient developed chest pain and pruritic skin rashes. Kounis syndrome type I variant was diagnosed secondary to the drug. Five days after stopping the drug, the patient's symptoms had resolved.

Frequency not reported: Kounis syndrome type I variant


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