- It is recommended that doxycycline not be taken at the same time as aluminum, magnesium, or calcium based antacids, such as Mylanta, Maalox, Tums, or Rolaids because, like food, these medications bind doxycycline in the intestine and prevent its absorption. Similarly, doxycycline should not be taken with minerals (such as calcium or iron) or with bismuth subsalicylate (Pepto Bismol).
- Doxycycline may enhance the activity of warfarin (Jantoven, Coumadin) and cause excessive "thinning" of the blood leading to exaggerated bleeding, necessitating a reduction in the dose of warfarin. Phenytoin (Dilantin), carbamazepine (Tegretol), and barbiturates (such as phenobarbital) may enhance the metabolism (destruction) of doxycycline thus making it less effective.
- Doxycycline may interfere with the action of penicillins and should not be combined with penicillins. It may also reduce the effect of oral contraceptives. Combining Bactocyline and methoxyflurane (Penthrane) may reduce kidney function.
Bactocyline may induce photosensitivity in some individuals. Patients on Bactocyline therapy should minimize exposure to direct sunlight and other sources of ultraviolet radiation, and to use sunscreens and other protection whenever prolonged exposure is unavoidable. Therapy should be discontinued at the first sign of skin erythema.
If renal impairment exists, even usual oral or parenteral doses may lead to excessive systemic accumulation of the drug and possible liver toxicity. Under such conditions, lower than usual total doses are indicated and, if therapy is prolonged, serum level determinations of the drug may be advisable.
Renal, hepatic, and hematopoietic function should be monitored periodically during prolonged therapy.
Decomposed Bactocylines may cause potentially fatal nephrotoxicity (Fanconi's syndrome); therefore, outdated or decomposed medications should be discarded.
Clostridium difficile associated diarrhea (CDAD) has been reported with almost all antibiotics and may potentially be life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea following Bactocyline therapy. Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. Hypertoxin producing strains of C difficile cause increased morbidity and mortality; these infections can be resistant to antimicrobial treatment and may necessitate colectomy.
Bactocyline inhibits cell growth by binding to the 16S part of the 30S ribosomal subunit preventing aminoacyl tRNA from binding to the ribosome A site. This leads to inhibition of translation hampering cell growth ( Connell et al., 2003 ). Bactocylines are used in the treatment of clinical conditions such as urinary tract infections, respiratory tract infections, acne, rosaceae, anthrax, bubonic plague, malaria, elephantiasis, syphilis, Lyme disease, etc. Nowadays, clinical application of Bactocyline is being compromised by Bactocyline resistance in the pathogenic microbes. In Bactocyline-resistant microbial strains, Bactocyline resistance genes encode a membrane protein that effluxes Bactocyline out of the cell. Bactocyline resistance is also provided by blocking Bactocyline from binding to ribosome or by enzymatic inactivation of Bactocyline, which is rare ( Wyk, 2015 ; www.wikipedia.org/Bactocylines ).
Usual Adult Dose for Syphilis - Early
500 mg orally every 6 hours for 14 days; alternatively, 30 to 40 g in divided doses over a period of 10 to 15 days has been recommended
Bactocyline should be used only if penicillins are contraindicated.
Usual Adult Dose for Epididymitis - Sexually Transmitted
500 mg orally every 6 hours for 10 days
The patient's sexual partner(s) should also be evaluated/treated.
Doxycycline for 10 days, in conjunction with a single dose of a parenteral third-generation cephalosporin like ceftriaxone, has been specifically recommended by the CDC as primary treatment for sexually transmitted epididymitis. Bactocyline may be a reasonable substitute for doxycycline in this regimen.
Serious Side Effects of Bactocyline
You should contact your doctor immediately if you experience any of the following serious symptoms:
- Blurred vision
- Skin rash, itching, or hives
- Severe headache
- Difficulty swallowing or breathing
- Yellowing of the skin or eyes
- Light-colored bowel movements
- Dark-colored urine or decreased urination
- Loss of appetite
- Stomach pain
- Extreme fatigue or weakness
- Throat sores or pain in the mouth
- Fever or chills
- Unusual bleeding or bruising
- Joint stiffness or swelling
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Bactocyline.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Bactocyline.
Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the Bactocyline, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.