Aticef may cause the following side effects: nausea, vomiting, diarrhea, dyspepsia, headache, dizziness, other infections (genital candidiasis, colitis), decrease in the number of white blood cells in the blood (leucopenia), joint pain, flu-like symptoms (fever and sore throat), liver damage followed with jaundice (yellowing of the skin and eyes), allergy (rash, itching, swelling of the face, swelling of the tongue and difficulty breathing).
Immediately tell your doctor if you are experiencing any of the abovementioned side effects.
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If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional.
Staphylococcus spp. that do not produce β-lactamase have a predictable susceptibility pattern to many of the penicillins and cephalosporins. Staphylococcus spp. are usually susceptible to oxacillin and dicloxacillin, but these are not typically administered to horses. Most staphylococci are sensitive to the fluoroquinolones and aminoglycos >Aticef , cefpodoxime, cefazolin), will increase activity to include β-lactamase–producing strains of staphylococci.
Recent reports have raised concerns of staphylococcal resistance in horses. 3-5 The isolated methicillin-resistant Staphylococcus aureus (MRSA) strains colonized both horses and people who were in contact with the horses (see Chapter 29 ). Evidence for human-to-animal transmission was reported. These strains were resistant to other antibiotics, in addition to β-lactams. Methicillin-resistant Staphylococcus aureus has been reported more often in some referral centers. These MRSA strains present an important problem for veterinarians because they are resistant to all β-lactam antibiotics, regardless of whether they are combined with a β-lactamase inhibitor. Some of these strains remain sensitive to chloramphenicol, tetracyclines, and TMS, but there may be cases for which the only active drugs are the glycopeptide vancomycin or the oxazolidinone linezolid (Zyvox). Vancomycin has been used sporadically in the treatment of equine MRSA as an intravenous (IV) infusion at doses of 4.3 to 7.5 mg/kg body weight every 8 hours (q8h). 6,7 There are no reports of clinical use of linezolid in horses, and at the time of this writing, its use is considered to be cost prohibitive. Instituting appropriate hygiene measures and the use of topical antibiotics (i.e., mupirocin) are also recommended, particularly in hospital situations. 8
1 g initially THEN 500 mg maintenance dose at intervals
CrCl 25-50 mL/min: q12hr
CrCl 10-25 mL/min: qDay
CrCl Enter a drug name and Aticef
In Vitro Disposition at the BCSFB
Studies in adult rat CP whole tissue, neonatal rat CP epithelial cells in primary culture, and genetically modified mice showed that PEPT2, located at the apical (CSF facing) as opposed to basolateral (blood-facing) membrane, is the primary member of the POT family responsible for the removal of neuropeptides, peptide fragments, and peptide-like drugs from the CSF. 12,28 In particular, Pept2 -deficient mice have marked reductions (≥90%) in their ability to transport GlySar, carnosine, and 5-aminolevulinic ac >Aticef (a β-lactam antibiotic), as determined in wild-type and PEPT2 null mice, is primarily mediated by PEPT2 (80–85%) and to a minor extent by organic anion transporters (10–15%) and nonspecific mechanisms (5%). This finding suggests that aminocephalosporins, which are recognized by PEPT2, may have reasonable access to the CSF but are rapidly removed by drug efflux transporters making them ineffective for the treatment of bacterial infections in the CNS. However, one must be careful in extrapolating the results with Aticef to other aminocephalosporin drugs. As reported by Kuroda et al., 13 small differences in chemical structure can substantially influence the mechanism of drug efflux from CSF. For example, cefaclor (3-chloro in dihydrothiazine ring) is eliminated from rat CSF by a benzylpenicillin-sensitive mechanism distinct from OAT3, whereas cephalexin (3-methyl in dihydrothiazine ring) is removed by a GlySar-sensitive transporter, presumably PEPT2.
Aticef (Duricef ) belongs to the drug class cephalosporin. Aticef (Duricef) is prescribed for bacterial infections such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Moraxella catarrhalis, E. coli, Klebsiella, and Proteus mirabilis, urinary tract infections (UTI), throat infections (sore throat), and tonsillitis. Review side effects, drug interactions, warnings and precautions, and efficacy during pregnancy information prior to taking this medication.
Pharmacologic class: First-generation cephalosporin
Therapeutic class: Anti-infective
Pregnancy risk category B
What is Aticef, and how does it work (mechanism of action)?
Aticef is an oral antibiotic in the cephalosporin family of drugs, a family that includes cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefixime (Suprax), and many other injectable antibiotics. Cephalosporins stop bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Cephalosporins are most effective when bacteria are actively multiplying and forming cell walls. Aticef is active against many bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Moraxella catarrhalis, E. coli, Klebsiella, and Proteus mirabilis. The FDA approved Aticef in 1977.
This article was medically reviewed by M.Pharm, Marko Tanaskovic on August 12, 2018. To read more about an author, click here.
Aticef is a drug from the group of cephalosporins (cephalosporin antibiotics). Aticef works by killing bacteria (bactericide) and it is used to treat a number of infections:
- Respiratory tract infections (tonsillitis, sore throat, pneumonia)
- Middle ear infections (otitis media)
- Gynecological infections
- Urinary tract infections (cystitis, pyelonephritis)
- Skin and soft tissue infections
Use of Aticef during pregnancy and breastfeeding
According to FDA, Aticef belongs to group B (FDA: Group B). This means that animal studies have shown that Aticef is not harmful to the fetus, but there are no studies on humans. Consult your doctor about the benefits and risks of using Aticef during pregnancy.
Aticef passes into breast milk, so you will need to avoid breastfeeding while taking Aticef capsules.
Aticef is available as veterinary-formulated tablets or suspension for small animals. Cephalexin is available as human tablets and suspensions for oral administration. Cefpodoxime proxetil is available as veterinary-formulated tablets (100 or 200 mg) for dogs. Cefepime (human) and ceftiofur (food animal “ready to use”) are available as hydrochloride formulations. Ceftiofur sodium is labeled for horses and is available as a 1-g or 4-g sterile powder to be reconstituted in sterile water to a final concentration of 50 mg/mL. Once reconstituted, the product is stable for up to 12 hours at room temperature, 7 days when refrigerated, and 6 months when frozen. CCFA is available as sterile suspension equivalent to 200 mg/mL of ceftiofur in a caprylic/capric triglyceride and cottonseed oil base.
What form(s) does this medication come in?
Each white and maroon No. 0 capsule, imprinted "APO 500", contains Aticef 500 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium stearic acid, talc, FD&C Blue No. 1, FD&C Red No. 40, gelatin, grey ink, silicon dioxide, sodium lauryl sulphate, titanium dioxide, and edible grey ink.
ВїPara cuГЎles condiciones o enfermedades se prescribe este medicamento?
El Aticefo se usa para tratar algunas infecciones provocadas por bacterias, tales como infecciones de la piel, garganta, amГgdalas, y del tracto urinario. El Aticefo pertenece a una clase de medicamentos llamados antibiГіticos de cefalosporina. Funciona matando las bacterias.
Los antibiГіticos como el Aticefo no funcionan para combatir resfriados, influenza u otras infecciones virales. Usar antibiГіticos cuando no son necesarios aumenta su riesgo de contraer una infecciГіn mГЎs adelante, que se resista al tratamiento con antibiГіtico.
Cephalosporin dosages for cats and dogs are listed in Table 8-4 . First-generation cephalosporins such as cephalexin are moderately absorbed orally and distributed into extracellular flu >Aticef ). 7 Cefazolin has been a popular injectable antibiotic for perioperative use in small animals. This perioperative use of cefazolin is with the intention to prevent postsurgical infections, particularly in orthopedic surgery (see Chapter 85 ).
TABLE 8-4 . Suggested Cephalosporin Dosages for Small Animals
Which drugs or supplements interact with Aticef?
Aticef may reduce the immune response to BCG (tuberculosis vaccine) and typhoid live vaccines and result in less effective vaccination.