Ampibex capsules

Ampibex

  • Active Ingredient: Ampicillin
  • 500 mg, 250 mg
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What is Ampibex?

The active ingredient of Ampibex brand is ampicillin. Ampicillin is a penicillin antibiotic that fights bacteria. The molecular formula is C16H18N3NaO4S, and the molecular weight is 371.39. The pH range of the reconstituted solution is 8 to 10.

Used for

Ampibex is used to treat diseases such as: Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bronchitis, Endocarditis, Gastroenteritis, Intraabdominal Infection, Kidney Infections, Leptospirosis, Meningitis, Otitis Media, Peritonitis, Pharyngitis, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Septicemia, Shigellosis, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Typhoid Fever, Upper Respiratory Tract Infection, Urinary Tract Infection.

Side Effect

Possible side effects of Ampibex include: ; ; ; ; ; ; ; .

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Why is this medication prescribed?

Ampibex is used to treat certain infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord); and infections of the throat, sinuses, lungs, reproductive organs, urinary tract, and gastrointestinal tract. Ampibex is in a class of medications called penicillins. It works by killing bacteria.

Antibiotics such as Ampibex will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

What Are Side Effects Associated with Using Ampibex?

Common Side effects of Ampibex include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Ampibex?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Ampibex has no known severe interactions with other drugs.

Serious Interactions of Ampibex include:

Ampibex has moderate interactions with at least 29 different drugs.

Mild interactions of Ampibex include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Usual Pediatric Dose for Meningitis

PARENTERAL: Neonates: -Gestational age up to 34 weeks: ---Postnatal age up to 7 days: 100 mg/kg/day IV in equally divided doses every 12 hours ---Postnatal age 8 to 28 days: 150 mg/kg/day IV in equally divided doses every 12 hours -Gestational age greater than 34 weeks: ---Postnatal age up to 28 days: 150 mg/kg/day IV in equally divided doses every 8 hours

Children: 150 to 200 mg/kg/day IV in equally divided doses every 3 to 4 hours

ORAL: The manufacturer gives no specific dosing instructions.

Comments: -Therapy may be started with IV administration and continued with IM injections. -Use with an aminoglycoside may increase efficacy against gram-negative bacteria.

Uses: -Parenteral: For the treatment of bacterial meningitis due to E coli, group B streptococci, and other gram-negative bacteria (L monocytogenes, N meningitidis) -Oral: For the treatment of meningitis due to N meningitidis

AAP Recommendations: 1 month or older: 300 to 400 mg/kg/day IV divided in 6 doses Maximum dose: 12 g/day

IDSA Recommendations for Meningitis: -Neonates up to 7 days: 150 mg/kg/day IV in divided doses every 8 hours -Neonates 8 to 28 days: 200 mg/kg/day IV in divided doses every 6 to 8 hours -Infants and children: 300 mg/kg/day IV in divided doses every 6 hours ---Maximum dose: 12 g/day

Duration of Therapy: -Aerobic gram-negative bacilli: 21 days -H influenzae: 7 days -L monocytogenes: At least 21 days -N meningitidis: 7 days -S agalactiae: 14 to 21 days -S pneumoniae: 10 to 14 days

Comments: -IDSA: Smaller doses and longer dosing intervals may be prudent for very low-birth weight neonates (less than 2000 g). -IDSA: Based on presumptive pathogen identification by positive Gram stain: A recommended agent for infection due to L monocytogenes or S agalactiae (use with an aminoglycoside should be considered); recommended as an alternative agent for infection due to N meningitidis ---In children, this drug is added to the standard therapeutic regimen of cefotaxime or ceftriaxone plus vancomycin when L monocytogenes is considered and to an aminoglycoside if a gram-negative enteric pathogen is of concern. -IDSA: Based on isolated pathogen and susceptibility testing: Considered standard therapy for S pneumoniae or N meningitidis infection with penicillin MIC less than 0.1 mcg/mL, beta-lactamase negative H influenzae, and (with gentamicin) Ampibex-susceptible Enterococcus species; recommended as alternative therapy for infection due to E coli and other Enterobacteriaceae -Current guidelines should be consulted for additional information.

What should I discuss with my healthcare provider before taking Ampibex (Omnipen, Principen, Totacillin)?

You should not use this medicine if you are allergic to Ampibex or any similar antibiotic, such as amoxicillin (Amoxil, Augmentin, Moxatag, and others), dicloxacillin, nafcillin, or penicillin.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant.

Ampibex can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

You should not breast-feed while using Ampibex.

Do not give this medicine to a child without medical advice.

PRODUCT INFORMATION

REPRESENTATIVE TRADE NAMES

Ampibex – Generic, Principen®

Product labeling at DailyMed, National Library of Medicine, NIH

What is amoxicillin? What is Ampibex?

Amoxicillin is a penicillin-type antibiotic. Other members of this class include Ampibex (Unasyn), piperacillin (Pipracil), and ticarcillin (Ticar). These antibiotics do not directly kill bacteria, but they stop bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Amoxicillin is effective against many different bacteria including H. influenzae, N. gonorrhoea, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci. Amoxicillin is used to treat bacterial infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis), lungs (pneumonia), urinary tract, and skin. It also is used to treat gonorrhea.

Ampibex is a penicillin-type antibiotic used for treating bacterial infections middle ear, sinuses, stomach and intestines, bladder, and kidney caused by susceptible bacteria. It also is used for treating uncomplicated gonorrhea, meningitis, endocarditis and other serious infections. Other members of the same drug class include amoxicillin (Amoxil), piperacillin (Pipracil), and ticarcillin (Ticar). These antibiotics stop bacteria from multiplying by preventing bacteria from forming the cell walls that surround them. Ampibex is effective against many bacteria including H. influenzae, N. gonorrhoea, E. coli, Salmonella, and Shigella, streptococci and certain strains of staphylococci.

Usual Adult Dose for Meningitis

Parenteral: 150 to 200 mg/kg/day IV in equally divided doses every 3 to 4 hours Oral: The manufacturer gives no specific dosing instructions.

Comments: -Therapy may be started with IV administration and continued with IM injections. -Use with an aminoglycoside may increase efficacy against gram-negative bacteria.

Uses: -Parenteral: For the treatment of bacterial meningitis due to Escherichia coli, group B streptococci, and other gram-negative bacteria (Neisseria meningitidis) -Oral: For the treatment of meningitis due to N meningitidis

IDSA Recommendations: 12 g/day IV in divided doses every 4 hours

Duration of Therapy: -Aerobic gram-negative bacilli: 21 days -Haemophilus influenzae: 7 days -L monocytogenes: At least 21 days -N meningitidis: 7 days -S agalactiae: 14 to 21 days -S pneumoniae: 10 to 14 days

Comments: -Based on presumptive pathogen identification by positive Gram stain: A recommended agent for infection due to L monocytogenes or S agalactiae (use with an aminoglycoside should be considered); recommended as an alternative agent for infection due to N meningitidis -Based on isolated pathogen and susceptibility testing: Considered standard therapy for S pneumoniae or N meningitidis infection with penicillin MIC less than 0.1 mcg/mL, beta-lactamase negative H influenzae, and (with gentamicin) Ampibex-susceptible Enterococcus species; recommended as alternative therapy for infection due to E coli and other Enterobacteriaceae -Current guidelines should be consulted for additional information.


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