Ampexin capsules

Ampexin

  • Active Ingredient: Ampicillin
  • 500 mg, 250 mg
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What is Ampexin?

The active ingredient of Ampexin brand is ampicillin. Ampicillin is a penicillin antibiotic that fights bacteria. The molecular formula is C16H18N3NaO4S, and the molecular weight is 371.39. The pH range of the reconstituted solution is 8 to 10.

Used for

Ampexin is used to treat diseases such as: Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bronchitis, Endocarditis, Gastroenteritis, Intraabdominal Infection, Kidney Infections, Leptospirosis, Meningitis, Otitis Media, Peritonitis, Pharyngitis, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Septicemia, Shigellosis, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Typhoid Fever, Upper Respiratory Tract Infection, Urinary Tract Infection.

Side Effect

Possible side effects of Ampexin include: ; ; ; ; ; ; ; .

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What is the dosage for Ampexin?

The usual oral dose range for most infections is 250 to 500 mg 4 times daily for 7-14 days. Injectable doses range from 250 to 2000 mg 4 times daily. When used to treat gonorrhea, a single 3.5 gram dose (seven 500 mg capsules) is administered with 1 g probenecid (Benemid). The probenecid slows down the elimination of Ampexin so that Ampexin remains in the body longer. Food in the stomach reduces how much and how quickly Ampexin is absorbed. Therefore, Ampexin should be taken either 1 hour prior to or 2 hours following a meal for maximal absorption; however, for persons who experience nausea or stomach distress after taking Ampexin, it may be taken with meals.

OVERVIEW

Ampexin is considered a third generation or aminopenicillin and is used widely to treat mild-to-severe infections due to susceptible organisms. Ampexin has been linked with idiosyncratic liver injury, but very rarely and in isolated case reports.

Responses (1)

Yes, if the bacteria which caused your urinary tract infections is sensitive to Ampexin and does not produce beta-lactamases. I think you should ask your doctor to pass some clinical test to determine which bacteria caused the infection. The are known a lot of medications used for urogenital infections. The choice of a certain antibiotic depends if the microorganisms are sensitive to it

Before taking this medicine

You should not use Ampexin if you are allergic to Ampexin or any similar antibiotic, such as amoxicillin (Amoxil, Augmentin, Moxatag, and others), dicloxacillin, nafcillin, or penicillin.

Tell your doctor if you have ever had:

kidney disease; or

an allergy to a cephalosporin antibiotic.

Tell your doctor if you are pregnant.

Ampexin can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

You should not breast-feed while using Ampexin.

Do not give this medicine to a child without medical advice.

How should this medicine be used?

Ampexin comes as a capsule and a suspension (liquid) to take by mouth. It is usually taken three to four times a day, either half an hour before or two hours after meals. The length of your treatment depends on the type of infection that you have. Take Ampexin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Ampexin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the suspension well before each use to mix the medication evenly.

The medication should be taken with a full glass of water.

You should begin to feel better during the first few days of treatment with Ampexin. If your symptoms do not improve or get worse, call your doctor.

Take Ampexin until you finish the prescription, even if you feel better. If you stop taking Ampexin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Mechanism of Injury

The cause of the liver injury associated with Ampexin use is probably hypersensitivity or allergy. Few cases of rechallenge or reexposure have been reported.

What should I avoid while taking Ampexin (Omnipen, Principen, Totacillin)?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

GENERIC NAME(S): Ampexin Sodium

OTHER NAME(S): Ampexin Sodium Solution, Reconstituted (Recon Soln)

Ampexin is used to treat a wide variety of bacterial infections. It is a penicillin-type antibiotic. It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

What should I avoid while taking Ampexin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Contraindications

  • Hypersensitivity
  • Infectious mononucleosis

Effects of Drug Abuse

  • No information available

  • See "What Are Side Effects Associated with Using Ampexin?"

  • See "What Are Side Effects Associated with Using Ampexin?"

  • Allergy to cephalosporins and/or carbapenems
  • Adjust dose in renal failure; evaluate rash and differentiate from hypersensitivity reaction
  • Endocarditis prophylaxis: Use only for high-risk patients, per American Heart Association Guidelines
  • Prolonged use associated with fungal or bacterial superinfection

  • Use of Ampexin may be acceptable during pregnancy
  • Either animal studies show no risk but human studies are not available or animal studies showed minor risks and human studies were done and showed no risk
  • Ampexin is excreted in breast milk; use with caution while breastfeeding

Info about how buy Medaclav tablets for treatment Helicobacter Pylori Infection

Ampexin

Common side effects of Ampexin include:

Patients with a history of allergic reactions to other penicillins should not receive Ampexin. Persons who are allergic to the cephalosporin class of antibiotics, which are related to the penicillins may or may not be allergic to penicillins . Serious but rare reactions include seizures, severe allergic reactions (anaphylaxis), and low platelet or red blood cell count.

Ampexin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting Ampexin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.

DOSAGE AND ADMINISTRATION

Adults and Children Weight Over 20 kg.

For genitourinary or gastrointestinal tract infections other than gonorrhea in men and women, the usual dose is 500 mg qid in equally spaced doses; severe or chronic infections may require larger doses.

For the treatment of gonerrhea in both men and women, a single oral dose of 3.5 grams of Ampexin administered simultaneously with 1 gram of probenecid is recommended. Physicians are cautioned to use no less than the above recommended dosage for the treatment of gonorrhea. Follow-up cultures should be obtained from the original site(s) of infection 7 to 14 days after therapy. In women, it is also desirable to obtain culture test-of-cure from both the endo-cervical and anal canals. Prolonged intensive therapy is needed for complications such as proshtitis and epididymitis. For respiratory tract infections, the usual dose is 250 mg qid in equally spaced doses.

Children Weighing 20 kg or Less

For genitourinary or gastrointestinal tract infections, the usual dose is 100 mg/kg/day total, qid in equally divided and spaced doses. For respiratory infections, the usual dose is 50 mg/kg/day total, in equally divided and spaced doses three to four times daily. Doses for children should not exceed doses recommended for adults,

All Patients, Irrespective of Age and Weight

Larger doses may be required for severe or chronic infections. Although Ampexin is resistant to degradation by gastric acid, it should be administered at least one half-hour before or two hours after meals for maximal absorption. Except for the single dose regimen for gonorrhea referred to above, therapy should be continued for a minimum of 48 to 72 hours after the patient becomes asymptomatic or evidence at bacterial eradication has been obtained. In infections caused by hemolytic strains of streptococci, a minimum of 10 days treatment is recommended to guard against the risk of rheumatic fever of glomerulonephritis (see PRECAUTIONS — Laboratory Tests). In the treatment of chronic urinary or gastrointestinal infections, frequent bacteriologic and clinical appraisal is necessary during therapy and may be necessary for several months afterwards. Stubborn infections may require treatment for several weeks. Smaller doses than those indicated above should not be used.

Ampexin, drug used in the treatment of various infections, including otitis media (middle ear infection), sinusitis, and acute bacterial cystitis. Ampexin (or alpha-aminobenzylpenicillin) is a semisynthetic penicillin, one of the first such antibiotics developed. Similar in action to penicillin G but more effective against gram-negative bacteria, Ampexin is more stable in stomach acids and therefore may be given orally.

The potential s > allergic reactions ranging from skin rashes and hives to life-threatening anaphylactic shock (very rare). People who are allergic to other drugs in this family are also likely to react to Ampexin. The incidence of skin rash is higher with Ampexin than with other penicillins, a factor that suggests a possible toxic reaction as well as a truly allergic response.

PRODUCT INFORMATION

REPRESENTATIVE TRADE NAMES

Ampexin – Generic, Principen®

Product labeling at DailyMed, National Library of Medicine, NIH


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