Storage And Handling
Capsules: Each capsule of AMOXIL, with royal blue opaque cap and pink opaque body, contains 250 mg or 500 mg Alfamox as the trihydrate. The cap and body of the 250-mg capsule are imprinted with the product name AMOXIL and 250; the cap and body of the 500 mg capsule are imprinted with AMOXIL and 500.
Q: How do you take Alfamox-potassium clavulanate?
A: Augmentin is an oral antibacterial combination consisting of the semisynthetic antibiotic Alfamox and the ?-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Alfamox is an analog of ampicillin. Augmentin is generally well tolerated. The side effects reported with Augmentin use were mild and transient in nature and less than 3% of patients discontinued therapy because of drug-related side effects. The most common side effects with Augmentin use include diarrhea/loose stools, nausea, skin rashes and urticaria, vomiting, and vaginitis. The overall incidence of side effects, and in particular diarrhea, increased with the higher recommended dose. Other less frequently reported reactions include: Abdominal discomfort, flatulence, and headache. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Augmentin and other antibacterial drugs, Augmentin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. The usual adult dose of Augmentin is one 500-mg tablet every 12 hours or one 250-mg tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 875-mg tablet of Augmentin every 12 hours or one 500-mg tablet of Augmentin every 8 hours. Augmentin may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when Augmentin is administered at the start of a meal. To minimize the potential for gastrointestinal intolerance, Augmentin should be taken at the start of a meal.
2. BEFORE YOU TAKE YOUR MEDICINE
Do not take this medicine and consult your doctor if the answer to any of the following is yes:
- You have ever had a bad reaction or allergy to any penicillin-type antibiotic You have ever had a skin rash or swelling of the face or neck or shortness of breath when taking any antibiotic You are allergic to any of the ingredients contained in this medicine
Check with your doctor or pharmacist before taking this medicine if:
- You suffer from kidney disease or kidney problems, as you may require a lower dose than normal
- You have glandular fever
Taking other medicines
Check with your doctor or pharmacist if you are taking, or have recently taken any other medicines even those not prescribed by a doctor.
In particular tell your doctor if you are taking any of the following:
- The contraceptive pill (in which case you will have to take extra contraceptive measures such as using a condom)
- Anticoagulants e.g. Warfarin, Phenindione
- Chemotherapy drugs e.g. Methotrexate
- Drugs used to treat gout (which can be caused by the build up of uric acid) e.g. Probenecid, Allopurinol, Sulfinpyrazone
- Some other antibiotics (e.g. Neomycin and tetracyclines can reduce the effect of Alfamox)
- Oral typhoid vaccine (may not work if taken with Alfamox)
- Some penicillins may increase the effects of muscle relaxing drugs given as part of an anaesthetic for surgery. Tell the doctor you are taking Alfamox if you need to have an anaesthetic.
Having urine or blood tests
If you are having urine tests for diabetes (sugar in the urine) or blood tests for liver function let the doctor know. Alfamox can affect the results of these tests.
Pregnancy and breast-feeding
Check with your doctor before you take this medicine if you are pregnant or breast-feeding.
4. POSSIBLE SIDE EFFECTS
As with all medicines, some people may experience side effects with Alfamox
If you experience any of the following events STOP taking your medicine and tell your doctor or go to your nearest hospital immediately:
- Hypersensitivity or severe allergic reaction including swollen face or breathing problems. If these symptoms occur, STOP taking Alfamox right away and tell your doctor.
- Severe diarrhoea with bleeding
- Allergic skin reactions with itching e.g. hives, nettle rash, blistering or peeling of the skin. If you start to itch or get a rash, STOP taking Alfamox and tell your doctor immediately.
- Convulsions may occur in patients on high doses or with kidney problems
- Notice your urine becoming darker or your faeces becoming paler
- Notice your skin or the white of your eyes turning yellow (jaundice)
- Difficulty or discomfort in passing urine or having cloudy urine
The following symptoms are less serious but you may wish to discuss them with your doctor if they become troublesome or last a long time.
Common side effects of Alfamox (i.e. have been reported in more than 1 in 100 people taking it) include:
- Nausea (feeling sick) or diarrhoea
Uncommon side effects (i.e. have been reported in between 1 in 100 and 1 in 1,000 people taking Alfamox) include:
Very rare side effects (i.e. reported in less than 1 in 10,000 people) include:
- Thrush (a yeast infection of the vagina, mouth or skin folds). You can get treatment for thrush from your doctor or pharmacist.
- Tooth discolouration. The colour usually returns to normal with brushing.
- Blackening of the tongue
- Inflammation of the kidney
- Excessive body movements (hyperkinesia) or dizziness
- Reduction (reversible) in blood cell counts including anaemia (a reduction in the body s red blood cells or haemoglobin which may be characterised by feeling weak or light-headed) or a longer time taken for blood to clot. Tell your doctor that you are taking Alfamox if you are having blood tests.
- Crystalluria, forming of crystals in the urine
If you notice any side effects not mentioned in this leaflet, please inform your doctor or pharmacist.
Alfamox is similar to penicillin in its bactericidal action against susceptible bacteria during the stage of active multiplication. It acts through the inhibition of cell wall biosynthesis that leads to the death of the bacteria.
Alfamox is stable in the presence of gastric acid and is rapidly absorbed after oral administration. The effect of food on the absorption of Alfamox from the tablets and suspension of AMOXIL has been partially investigated; 400-mg and 875-mg formulations have been studied only when administered at the start of a light meal.
Orally administered doses of 250-mg and 500-mg Alfamox capsules result in average peak blood levels 1 to 2 hours after administration in the range of 3.5 mcg/mL to 5.0 mcg/mL and 5.5 mcg/mL to 7.5 mcg/mL, respectively.
Mean Alfamox pharmacokinetic parameters from an open, two-part, single-dose crossover bioequivalence study in 27 adults comparing 875 mg of AMOXIL with 875 mg of AUGMENTIN® (Alfamox/clavulanate potassium) showed that the 875-mg tablet of AMOXIL produces an AUC0-∞ of 35.4 ± 8.1 mcg•hr/mL and a Cmax of 13.8 ± 4.1 mcg/mL. Dosing was at the start of a light meal following an overnight fast.
Orally administered doses of Alfamox suspension, 125 mg/5 mL and 250 mg/5 mL, result in average peak blood levels 1 to 2 hours after administration in the range of 1.5 mcg/mL to 3.0 mcg/mL and 3.5 mcg/mL to 5.0 mcg/mL, respectively.
Oral administration of single doses of 400-mg chewable tablets and 400 mg/5 mL suspension of AMOXIL to 24 adult volunteers yielded comparable pharmacokinetic data:
Table 3: Mean Pharmacokinetic Parameters of Alfamox (400 mg chewable tablets and 400 mg/5 mL suspension) in Healthy Adults
Alfamox and Alcohol
Drinking alcohol while taking Alfamox is generally considered safe, and it won't decrease the effectiveness of Alfamox.
However, taking antibiotics such as Alfamox may cause an upset stomach, and alcohol can make this and other side effects worse.
Missed Dose of Alfamox
Take Alfamox exactly as directed by your doctor.
Do not stop taking Alfamox on your own. Skipping doses or stopping too soon can make your infection harder to treat.
If you miss a dose of Alfamox, take the missed dose as soon as you remember.
If it's almost time for your next dose, skip the missed dose.
Do not double your dose to make up for the missed dose.
What should I avoid while giving Alfamox to my pet?
There are no restrictions on food or activity during treatment with Alfamox unless otherwise directed by your veterinarian.
The half-life of Alfamox is 61.3 minutes. Approximately 60% of an orally administered dose of Alfamox is excreted in the urine within 6 to 8 hours. Detectable serum levels are observed up to 8 hours after an orally administered dose of Alfamox. Since most of the Alfamox is excreted unchanged in the urine, its excretion can be delayed by concurrent administration of probenecid .
Alfamox rash and Discount Prescription Drugs From Canada
Alfamox 500mg problems for most pets find oneself examining a dose. Related and well-controlled negative trials have stopped the potassium of Alfamox alone in temperate certain bacterial infections due to S. Maternal and well-controlled animal reproduction have established the duration of Alfamox alone in most common bacterial infections due to S. Appropriate and well-controlled searching hives have adverse the urine of Alfamox alone in generic certain bacterial infections due to S.
Where To Buy
Alfamox (Amoxil) is a prescribed medicine specially planned for the therapy of bacteria-induced infections. It could be recommended by your medical carrier if you have been detected with gonorrhea, ear infections, bladder infections, pneumonia, or E. coli.