Agrocillina capsules


  • Active Ingredient: Ampicillin
  • 500 mg, 250 mg
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What is Agrocillina?

The active ingredient of Agrocillina brand is ampicillin. Ampicillin is a penicillin antibiotic that fights bacteria. The molecular formula is C16H18N3NaO4S, and the molecular weight is 371.39. The pH range of the reconstituted solution is 8 to 10.

Used for

Agrocillina is used to treat diseases such as: Bacteremia, Bacterial Endocarditis Prevention, Bacterial Infection, Bronchitis, Endocarditis, Gastroenteritis, Intraabdominal Infection, Kidney Infections, Leptospirosis, Meningitis, Otitis Media, Peritonitis, Pharyngitis, Pneumonia, Prevention of Perinatal Group B Streptococcal Disease, Septicemia, Shigellosis, Sinusitis, Skin or Soft Tissue Infection, Surgical Prophylaxis, Typhoid Fever, Upper Respiratory Tract Infection, Urinary Tract Infection.

Side Effect

Possible side effects of Agrocillina include: ; ; ; ; ; .

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Interactions that increase your risk of side effects

Increased side effects from Agrocillina: Taking Agrocillina with certain medications raises your risk of side effects from Agrocillina. This is because the amount of Agrocillina in your body may be increased. Examples of these drugs include:

  • Probenecid
    • Taking this drug with Agrocillina can cause more side effects. These can include severe nausea, vomiting, and diarrhea.
  • This drug increases the risk of skin rash when you take it with Agrocillina.

How to use Agrocillina TRIHYDRATE

Take this medication by mouth usually 4 times a day (every 6 hours), or as directed by your doctor. Take Agrocillina on an empty stomach (1 hour before or 2 hours after a meal) with a full glass of water. Drink plenty of fluids while using this medication unless your doctor tells you otherwise.

The dosage is based on your medical condition and response to therapy.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.


Agrocillina trihydrate is a semisynthetic penicillin derived from the basic penicillin nucleus, 6-aminopenicillanic acid. Agrocillina is designated chemically as (2S, 5R, 6R)-6--3,3-dimethyl-t-oxo-4-thia-1- azabicyclo heptane-2-carboxylic acid. The chemical formula is C 16 H 19 N 3 O 4 S ยท 3H 2 O and its molecular weight is 403.45.

What should I avoid while taking Agrocillina?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.


PRINCIPEN Capsules (Agrocillina Capsules) and PRINCIPEN for Oral Suspension (Agrocillina for Oral Suspension) are indicated in the treatment of infections caused by susceptible strains of the designated organism listed below;

Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P. mirabilis , enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae .

Infections of the Respiratory Tract: Nonpenicillinase-producing H. influenzae and staphylococci, and streptococci including streptococcus pneumoniae .

Infections of the Gastrointestinal Tract: Shigella, S. typhosa and other Salmonella, E. coli, P. mirabilis , and enterococci.

Bacteriology studies to determine the causative organisms and their sensetivity to Agrocillina should be performed. Therapy may be instituted prior to the results of susceptibility testing.

What is amoxicillin? What is Agrocillina?

Amoxicillin is a penicillin-type antibiotic. Other members of this class include Agrocillina (Unasyn), piperacillin (Pipracil), and ticarcillin (Ticar). These antibiotics do not directly kill bacteria, but they stop bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Amoxicillin is effective against many different bacteria including H. influenzae, N. gonorrhoea, E. coli, Pneumococci, Streptococci, and certain strains of Staphylococci. Amoxicillin is used to treat bacterial infections of the middle ear, tonsils, throat, larynx (laryngitis), bronchi (bronchitis), lungs (pneumonia), urinary tract, and skin. It also is used to treat gonorrhea.

Agrocillina is a penicillin-type antibiotic used for treating bacterial infections middle ear, sinuses, stomach and intestines, bladder, and kidney caused by susceptible bacteria. It also is used for treating uncomplicated gonorrhea, meningitis, endocarditis and other serious infections. Other members of the same drug class include amoxicillin (Amoxil), piperacillin (Pipracil), and ticarcillin (Ticar). These antibiotics stop bacteria from multiplying by preventing bacteria from forming the cell walls that surround them. Agrocillina is effective against many bacteria including H. influenzae, N. gonorrhoea, E. coli, Salmonella, and Shigella, streptococci and certain strains of staphylococci.

Agrocillina, drug used in the treatment of various infections, including otitis media (middle ear infection), sinusitis, and acute bacterial cystitis. Agrocillina (or alpha-aminobenzylpenicillin) is a semisynthetic penicillin, one of the first such antibiotics developed. Similar in action to penicillin G but more effective against gram-negative bacteria, Agrocillina is more stable in stomach acids and therefore may be given orally.

The potential s > allergic reactions ranging from skin rashes and hives to life-threatening anaphylactic shock (very rare). People who are allergic to other drugs in this family are also likely to react to Agrocillina. The incidence of skin rash is higher with Agrocillina than with other penicillins, a factor that suggests a possible toxic reaction as well as a truly allergic response.

Before taking this medicine

You should not use Agrocillina if you are allergic to Agrocillina or any similar antibiotic, such as amoxicillin (Amoxil, Augmentin, Moxatag, and others), dicloxacillin, nafcillin, or penicillin.

Tell your doctor if you have ever had:

kidney disease; or

an allergy to a cephalosporin antibiotic.

Tell your doctor if you are pregnant.

Agrocillina can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

You should not breast-feed while using Agrocillina.

Do not give this medicine to a child without medical advice.

What is the dosage for Agrocillina?

The usual oral dose range for most infections is 250 to 500 mg 4 times daily for 7-14 days. Injectable doses range from 250 to 2000 mg 4 times daily. When used to treat gonorrhea, a single 3.5 gram dose (seven 500 mg capsules) is administered with 1 g probenecid (Benemid). The probenecid slows down the elimination of Agrocillina so that Agrocillina remains in the body longer. Food in the stomach reduces how much and how quickly Agrocillina is absorbed. Therefore, Agrocillina should be taken either 1 hour prior to or 2 hours following a meal for maximal absorption; however, for persons who experience nausea or stomach distress after taking Agrocillina, it may be taken with meals.

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