• Active Ingredient: Valacyclovir
  • 1000 mg, 500 mg
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What is Zelitrex?

The active ingredient of Zelitrex brand is valacyclovir. Valacyclovir is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection.

Used for

Zelitrex is used to treat diseases such as: CMV Prophylaxis, Cold Sores, Herpes Simplex, Mucocutaneous/Immunocompetent Host, Herpes Simplex, Mucocutaneous/Immunocompromised Host, Herpes Simplex, Suppression, Herpes Zoster, Multiple Sclerosis, Ramsay Hunt Syndrome, Varicella-Zoster.

Side Effect

Possible side effects of Zelitrex include: feeling, seeing, or hearing things that are not there; severe sunburn; changes in behavior, especially in interactions with other people; back, leg, or stomach pains; loss of voice.

How to Buy Zelitrex online?

To get Zelitrex online - just click on the "Buy Now" button in the top and follow on to our shop. Order and payment takes a few minutes, and all steps are evident. We do not require a medical prescription plus also we have many procedures of payment. With all the details of fast shipping and confidentiality, you may read on the applicable pages on the hyperlinks from the top menu.

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  • VALTREX may be given without regard to meals.
  • Zelitrex oral suspension (25 mg/mL or 50 mg/mL) may be prepared extemporaneously from 500-mg VALTREX Caplets for use in pediatric patients for whom a solid dosage form is not appropriate .


See also Side Effects section.

Before taking Zelitrex, tell your doctor or pharmacist if you are allergic to it; or to acyclovir; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems.

This drug may rarely make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not have certain immunizations/vaccinations (such as vaccines against the varicella virus) without the consent of your doctor.

Older adults may be more sensitive to the side effects of this drug, especially mental/mood changes (such as confusion, agitation) and kidney problems (such as a change in the amount of urine).

Cold sores can spread easily. Avoid close physical contact with others (such as kissing) during an outbreak until the cold sores have completely healed. Try not to touch the cold sore. If you do, wash your hands afterward.

Zelitrex does not prevent the spread of herpes. To lower the chance of giving genital herpes to your partner, do not have sexual contact during an outbreak or if you have symptoms. You can spread genital herpes even if you do not have symptoms. Therefore, always use an effective barrier method (latex or polyurethane condoms/dental dams) during all sexual activity. Consult your doctor or pharmacist for more details.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Zelitrex is used to treat shingles, chickenpox, cold sores, and genital herpes. Although the drug cannot cure these conditions, it can help prevent recurrent genital herpes outbreaks and decrease the spread of the virus. In addition, Zelitrex is used for the treatment of blisters and rashes that occur as a result of the infection. Off-label uses include the treatment of chickenpox and other viral infections.

Our free DiscountRx savings card can help you and your family save money on your prescriptions. This card is accepted at all major chain pharmacies, nationwide. Enter your name and email address to receive your free savings card.

Our free DiscountRx savings card can help you and your family save money on your prescriptions. This card is accepted at all major chain pharmacies, nationwide. Enter your name and email address to receive your free savings card.

What else should I know about Valtrex (Zelitrex)?

  • Zelitrex) is available as tablets of 500 and 1000 mg
  • Valtrex should be kept stored between 2 C and 30 C (36 F and 86 F).
  • Zelitrex is available in generic form. You need a prescription from your doctor for it.

Q: Does Valtrex have any side effects that I should be concerned about over the long-term? I'm currently taking it for a first-time outbreak of herpes and don't know yet if I will have to take it daily or not.

A: Valtrex (Zelitrex) is a medication that is used to treat cold sores, shingles, chickenpox and genital herpes. All of these conditions are caused by the herpes virus and Valtrex works by helping the body fight the infection by preventing the virus from replicating. Valtrex also works to prevent outbreaks from recurring. According to the prescribing information on Valtrex, the most common side effects of the medication are: headaches, nausea, abdominal pain, depression, vomiting, joint pain, dizziness, and increased liver enzymes. The prescribing information does not have information on the safety of this medication past one year of therapy. The clinical studies that were conducted did not go longer than one year. If you have any type of immune system suppression or kidney conditions you should tell your physician because a change in dosage is necessary in these situations. Lori Poulin, PharmD

How Long Does it Take for Zelitrex to Work?

Once in the blood, Zelitrex starts to work almost immediately. Since it specifically attacks the DNA replication process, it will only attack herpes viruses that are reproducing; so while it starts to work on an active infection very quickly, it will not fight the virus that is inactive and hiding in the nervous system.

Nevertheless, if taken on a daily basis it may reduce the number of outbreaks a person might experience by 70%–80% and reduce the risk of transmitting herpes to a partner by about 50%. Taken at the earliest feelings that an outbreak is on the verge of occurring, Zelitrex may either abort the attack or shorten how long it will last. Remember, with Zelitrex treatment for herpes, the earlier you take it after the symptoms appear, the better.

While it goes to work within hours of taking the medication, the symptoms and sores of an actual outbreak may take days to begin to heal and the virus can stay active throughout the healing process.

Outcome and Management

No instances of acute liver failure or chronic liver injury have been linked to Zelitrex use. The liver injury associated with Zelitrex is usually mild and resolves rapidly. There is no information on possible cross sensivity of hepatic injury among the various nucleoside analogues used to treat herpes virus infections.

Q: Is Valtrex safe during Pregnancy?

A: Valtrex (Zelitrex) is an antiviral medication classified by the U.S. Food and Drug Administration (FDA) as Pregnancy Category B. Studies of Valtrex performed in animals, at doses which precipitated 10 and 7 times the human plasma levels in rats and rabbits respectively, during the formation and differentiation of organs and organ systems during embryonic development, revealed no evidence of teratogenicity. However, there are no adequate and well-controlled studies evaluating Valtrex in pregnant women. According to Briggs' Drugs in Pregnancy and Lactation, for the management of herpes in pregnancy, Valtrex is recommended for primary or first-episode infection (for 7 to 10 days), symptomatic recurrent episode (for 5 days), and daily suppression (from 36 weeks' gestation until delivery). Experience with Valtrex in early pregnancy is limited. The Briggs' Fetal Risk Recommendation indicates that previous experience with Valtrex in human pregnancy, either for the drug itself or drugs in the same class or with similar mechanisms of action, is adequate to demonstrate that the risk to the embryo/fetus is very low or nonexistent. According to the prescribing information, Valtrex should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The use of Valtrex during pregnancy is patients specific and must be properly evaluated by a health care provider.

Zelitrex is a nucleoside analogue DNA polymerase inhibitor. Zelitrex hydrochloride is rapidly converted to acyclovir which has demonstrated antiviral activity against HSV types 1 (HSV-1) and 2 (HSV-2) and VZV both in cell culture and in vivo.

The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In biochemical assays, acyclovir triphosphate inhibits replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared with VZV is due to its more efficient phosphorylation by the viral TK.

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