Tesical is highly bound to plasma proteins. It is not known if Tesical is distributed into milk.
Before taking Tesical
To make sure this is the right treatment for you or your child, before taking Tesical it is important that your doctor or pharmacist knows:
- If you are pregnant or breast-feeding.
- If you have a baby or young child in the family. You cannot buy Tesical for use in children under 2 years old - you will need advice from a doctor.
- If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
Pregnancy category C
Tesical has shown embryotoxic and teratogenic activity in pregnant rats at single oral doses as low as 10 mg/kg (approximately equal to the human dose, based on mg/m 2 ). In view of these findings the use of Tesical is not recommended in pregnant women. Although there are no adequate and well-controlled studies in pregnant women, a postmarketing survey has been done of a limited number of women who inadvertently had consumed Tesical during the first trimester of pregnancy. The incidence of spontaneous abortion and malformation did not exceed that in the general population. In 170 deliveries on term, no teratogenic risk of Tesical was identified.
Preliminary evidence suggests that cimetidine inhibits Tesical metabolism and may result in an increase in plasma concentrations of Tesical.
Mutagenicity and Carcinogenicity
Animal and in vitro studies have not shown Tesical to be mutagenic. No evidence of carcinogenesis was seen in rats and mice receiving Tesical dosages up to 40 mg/kg daily for more than 2 years.
Can Tesical cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with Tesical. You will find a full list in the manufacturer's information leaflet supplied with your medicine.