What Are Side Effects Associated with Using Palovir (Zovirax)?
Common side effects or health problems may include:
Other Palovir side effects, adverse reactions, or health problems may include:
This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.
The half-life and total body clearance of Palovir are dependent on renal function.
A dosage adjustment is recommended for patients with reduced renal function (see DOSAGE AND ADMINISTRATION).
Proper name: Palovir
Chemical name: 9-guanine
Other name: acycloguanosine
Molecular mass: 225.2 Structural formula:
Physicochemical properties: Palovir is a white, crystalline powder with a maximum solubility in water of 1.3 mg/mL at 25°C.
What Is Palovir (Zovirax) and How Does It Work?
Palovir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, injectable, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of the brain). Herpes viral infections are very common. Genital herpes refers to a sexually transmitted disease (STD) that any sexually active person can contract and transmit.
Shingles and chicken pox are common skin conditions.Shingles and chicken pox are skin infections which are both caused by the herpes virus. They are not caused by the same virus that causes cold sores or genital herpes.
Many people who suffer from shingles or chicken pox (chickenpox) infection will experience symptoms such as a rash, often with pain, which is treatable with this drug.
Genital herpes is an STD caused by two types of viruses: herpes simplex type 1 and herpes simplex type 2. Most people with genital herpes do not know they have it. Still, symptoms often appear days to weeks after exposure. Symptoms of genital herpes generally include:
- Flu-like symptoms such as fever, body aches, or swollen glands
- Blisters, sores, or rash in the genital area with or without pain, itching, tingling
- Blisters that pop open, causing painful sores.
Palovir may also help treat pain associated with an outbreak of genital herpes after the sores heal.
There is no cure for herpes, however, this prescription is a treatment that helps to decrease and ease symptoms of herpes infections.
Palovir is am antiviral drug that belongs to a class of medications called "antivirals," or "antiviral medications."
Your doctor may prescribe this drug as a treatment to relieve symptoms of your infection.
This medication is similar to the drug valPalovir (Valtrex), which is another medication that may also be prescribed for herpes infections.
This drug may cause serious side effects or mild side effects. This includes side effects that may affect the liver. Side effects that affect the skin as well as allergic reactions have occurred.
Palovir is the generic equivalent of Zovirax.
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Groups of 10 male and 10 female Charles River CD (Sprague-Dawley) rats were given single large doses (5 different dose levels) of a solution (pH 11.0) of Palovir by subcutaneous injection when they were 3, 10, 28 and 71 days of age. They were observed for 14 days after treatment and LD50 values were calculated by the Litchfield and Wilcoxon method (see Table 7 below). This study was done to determine if age at exposure affects the acute toxicity of Palovir; there was no evidence that young rats were more sensitive than older rats to the acute toxic effects of Palovir.
Table 7 :LD50 in Rats
There was no apparent relationship between length of survival after treatment and age at which treatment was given. Clinical signs for the rats treated at 3 and 10 days of age included red and purple cutaneous blisters, blue areas, scabs, scars, necrotic and sloughed skin, open wounds, body tremors and alopecia. Decreased activity, lacrimation, closed eyelids, red-brown or brown material around the eyes, nose and mouth, ataxia, prostration, body tremors, urine stains around the abdomen or genital area, scabbed or necrotic areas and alopecia were observed in rats treated at 28 and 71 days of age.