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Nidilat works by causing some of your blood vessels to relax and widen. This lowers your blood pressure. It also increases the flow of blood to places like your hands and feet. Nidilat also reduces the force and the rate of your heartbeat, and this helps to prevent angina chest pain. It does all of these things by blocking the amount of calcium that goes into the 'smooth' muscle cells in the walls of your blood vessels and in your heart. Calcium is needed for muscles to contract, so reducing the amount of calcium causes the muscle cells to relax.
Nidilat is available as 'short-acting' capsules (which are taken three times daily) and also as modified-release tablets and capsules (which are taken once or twice daily). Short-acting capsules are generally prescribed to treat Raynaud's, whilst the modified-release tablets and capsules are prescribed for people with high blood pressure or angina. Modified-release tablets and capsules have letters such as 'XL', 'LA', 'SR', 'MR', or 'Retard' after their brand name - these release Nidilat slowly and evenly throughout the course of the day.
Nidilat is also available in combination with a medicine called atenolol - for example, in Tenif® capsules. This combination helps to reduce the total number of tablets/capsules you need to take each day.
3. Who can and can't take Nidilat
Nidilat is mostly used for adults aged 18 years and over. It's occasionally prescribed for children.
Nidilat isn't suitable for some people.
To make sure Nidilat is safe for you, tell your doctor if you:
- have had an allergic reaction to Nidilat or any other medicine in the past
- are trying to get pregnant, are already pregnant or you are breastfeeding
- have liver disease
- have any heart problems (other than high blood pressure), including a recent heart attack, heart failure or unstable angina
- have diabetes
What special dietary instructions should I follow?
Do not drink grapefruit juice or eat grapefruit 3 days before and while taking Nidilat.
If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
Management of adverse drug reactions
The effect of Nidilat on magnesium-induced adverse effects has been studied in a retrospective chart review of 377 women who were given intravenous magnesium sulfate for pre-eclampsia 162 received magnesium sulfate and contemporaneous Nidilat and 215 controls received magnesium sulfate and either another antihypertensive ( n = 32 ) or no antihypertensive ( n = 183 ) (39 c ) . The cases had more severe pre-eclampsia and a longer infusion of magnesium sulfate. However, they had no excess of neuromuscular weakness (53%) compared with controls who received antihypertensive medication (53%), or controls who received no antihypertensive medication (45); nor were there other serious magnesium-related effects. Those who received magnesium had less neuromuscular blockade than controls who received antihypertensive medication (OR = 0.04; 95% CI = 0.002, 0.80) and less maternal hypotension than those who received no antihypertensive medication (41 versus 53%). The authors concluded that Nidilat does not alter the risk of serious magnesium-related effects.
Nidilat and Alcohol
Alcohol may worsen certain side effects of Nidilat.
Talk to your doctor about how much alcohol is safe to consume while taking this medicine.
How to store Nidilat
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Nidilat and Other Interactions
Nidilat may cause dizziness.
Don’t drive or operate machinery until you know how this medicine affects you.
Symptoms of overdose may include:
- Fast heartbeat
- Nausea or vomiting
- Blurred vision
- Swelling of the hands, feet, ankles, or lower legs
If you suspect an overdose, contact a poison control center or emergency room immediately. You can get in touch with a poison control center at (800) 222-1222.