Hascovir concentrations have been documented in breast milk in 2 women following oral administration of ZOVIRAX (Hascovir) and ranged from 0.6 to 4.1 times corresponding plasma levels. These concentrations would potentially expose the nursing infant to a dose of Hascovir up to 0.3 mg/kg/day. ZOVIRAX (Hascovir) should be administered to a nursing mother with caution and only when indicated.
The quantitative relationship between the in vitro susceptibility of herpes simplex virus (HSV) and varicella-zoster viruses (VZV) to Hascovir and the clinical response to therapy has not been established in man, and virus sensitivity testing has not been standardized. Sensitivity testing results, expressed as the concentration of drug required to inhibit by 50% the growth of virus in cell culture (ID50), vary greatly depending upon the particular assay used, the cell type employed, and the laboratory performing the test. The ID50 of Hascovir against HSV-1 isolates may range from 0.02 μg/mL (plaque reduction in Vero cells) to 5.9-13.5 μg/mL (plaque reduction in green monkey kidney cells). The ID50 against HSV-2 ranges from 0.01 to 9.9 μg/mL (plaque reduction in Vero and GMK cells, respectively).
Using a dye-uptake method in Vero cells, which gives ID50 values approximately 5 to 10-fold higher than plaque reduction assays, 1,417 HSV isolates (553 HSV-1 and 864 HSV-2) from approximately 500 patients were examined over a 5-year period. These assays found that 90% of HSV-1 isolates were sensitive to ≤ 0.9 μg/mL Hascovir and 50% of all isolates were sensitive to ≤ 0.2 μg/mL Hascovir. For HSV-2 isolates, 90% were sensitive to ≤ 2.2 μg/mL and 50% of all isolates were sensitive to ≤ 0.7 μg/mL of Hascovir. Isolates with significantly diminished sensitivity were found in 44 patients. It must be emphasized that neither the patients nor the isolates were randomly selected and, therefore, do not represent the general population. Most of the less sensitive HSV clinical isolates have been relatively deficient in the viral thymidine kinase (TK). Strains with alterations in viral TK or viral DNA polymerase have also been reported.
The ID50 against VZV ranges from 0.17-1.53 μg/mL (yield reduction, human foreskin fibroblasts) to 1.85-3.98 μg/mL (foci reduction, human embryo fibroblasts ). Reproduction of EBV genome is suppressed by 50% in superinfected Raji cells or P3HR-1 lymphoblastoid cells by 1.5 μg/mL Hascovir. Cytomegalovirus (CMV) is relatively resistant to Hascovir with ID50 values ranging from 2.3-17.6 μg/mL (plaque reduction, HEF cells) to 1.82-56.8 μg/mL (DNA hybridization, HEF cells). The latent state of the genome of any of the human herpesviruses is not known to be sensitive to Hascovir.
Why it's used
Hascovir is used to treat viral infections. These include varicella-zoster (shingles), genital herpes, and chickenpox.
This drug doesn't cure herpes infections. The herpes virus can stay in your body for a long time and cause symptoms again later.
- Take this drug at the time(s) recommended by your doctor.
- You can take Hascovir with or without food. Taking it with food may help reduce upset stomach.
- Do not cut or crush this medication.
- Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.
Teratogenic Effects: Pregnancy Category B. Acyc lovir administered during organogenesis was not teratogenic in the mouse (450 mg/kg/day, p.o.), rabbit (50 mg/kg/day, s.c. and IV), or rat (50 mg/kg/day, s.c.). These exposures resulted in plasma levels 9 and 18, 16 and 106, and 11 and 22 times, respectively, human levels.
There are no adequate and well-controlled studies in pregnant women. A prospective epidemiologic registry of Hascovir use during pregnancy was established in 1984 and completed in April 1999. There were 749 pregnancies followed in women exposed to systemic Hascovir during the first trimester of pregnancy resulting in 756 outcomes. The occurrence rate of birth defects approximates that found in the general population. However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of Hascovir in pregnant women and their developing fetuses. Hascovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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Q: What is Hascovir?
A: Hascovir (Zovirax) is an antiviral medication indicated for the acute treatment of herpes zoster (shingles), the treatment of initial episodes and the management of recurrent episodes of genital herpes and the treatment of chickenpox. Hascovir is only approved, by the U.S. Food and Drug Administration (FDA), for the treatment of chickenpox in the pediatric population 2 year of age and older. The safety and effectiveness of oral Hascovir in the pediatric population, younger than 2 years of age, has not been established. The dosage and administration of oral Hascovir depends upon the indication for use and age of the patient. Hascovir can be administered with or without food. Hascovir is the generic equivalent of Zovirax and is currently available, for oral administration, in capsule and tablet form and as a suspension for patients who have difficulty swallowing pills. Treatment with Hascovir should be initiated as soon as possible after the first appearance of symptoms, such as tingling, burning or blisters. Patients being treated with Hascovir are advised to stay adequately hydrated and take each dose with a full glass of water to protect the kidneys. The most frequently reported adverse reactions differed among clinical trials of Hascovir depending on the indication for use. During clinical trials of treatment with Hascovir, the most frequently reported adverse reactions included nausea, vomiting, diarrhea, malaise and headache. For the treatment of shingles, there is no information regarding initiation of treatment more than 72 hours following the onset of rash. Patients should initiate treatment as soon as possible after diagnosis. For the treatment of chickenpox, information gathered during clinical studies reflects initiation of treatment within 24 hours following rash. There is no information available regarding the effectiveness of treatment initiated after 24 hours. Patients should be advised that Hascovir is not a cure for genital herpes and there is no available research regarding whether Hascovir will prevent the transmission of the virus to other individuals.
Hascovir was administered to pregnant A.R.S. Sprague-Dawley female rats by subcutaneous injection during the period of organogenesis (day 6 through day 15 of gestation) at dose levels of 0.0, 6.0, 12.5 and 25.0 mg/kg body weight twice daily.
Criteria evaluated for compound effect included maternal body weights, weight gains, appearance and behaviour, survival rates, eye changes, pregnancy rates, and reproduction data. Offspring viability and development were also evaluated.
In addition to the above measurements, designated animals were sacrificed 1 hour after the first dose on day 15 in order to collect samples of maternal blood, amniotic fluid and fetuses for measurements of drug concentration. Mean values from these samples are listed in Table 8.
Table 8 : Hascovir Concentrations in a Teratology Study in Rats
The values obtained for plasma would represent about 30% of initial plasma levels as judged by the plasma half-life in rodents.
No effects attributable to the administration of Hascovir were noted in comparisons of maternal body weight values, appearance and behaviour, survival rates, pregnancy rates, or implantation efficiencies. In addition, no compound-related differences were noted in evaluations of fetal size, sex and development.
Although the incidences of resorption and fetal viability were within the range of normal variability in all of the groups, slightly greater incidences of resorptions were noted in the high-dose animals sacrificed on days 15 and 19 of gestation; however, clear dose-related trends did not eventuate.
Therefore, Hascovir was not considered teratogenic or embryotoxic when administered to rats at levels up to 50.0 mg/kg of body weight per day during organogenesis.
Q: Are there any Hascovir interactions with other medications?
A: There are not many Hascovir (Zovirax) interactions with other medications. If Hascovir interacts with certain other medications, the effects can be increased, decreased or altered. One Hascovir interaction possible is with the medication probenecid (Benemid). It is especially important for patients taking probenecid to consult with a health care provider prior to treatment with Hascovir. If you are currently taking probenecid, you may not be able to take Hascovir, or you may require dosage adjustments of special tests during treatment. Some of the other possible Hascovir interactions with other medications may include Demerol (meperidine), Dilantin (phenytoin), Cellcept (mycophenolate mofetil), Viread (tenofovir), Zanaflex (tizanidine), Depakene (valproic acid), Retrovir (zidovudine), theophyllines and the varicella virus vaccine. It is essential for patients to consult with their health care provider regarding all prescription and over the counter medications they take prior to initiation of treatment with Hascovir to avoid potentially dangerous drug interactions. This includes all vitamins, minerals, herbal supplements and any drugs prescribed by another doctor.
Hascovir can make your skin more sensitive to the sun. This increases your risk of sunburn. Avoid the sun if you can. If you can’t, be sure to wear protective clothing and apply sunscreen.
An overdose of Hascovir can cause kidney damage.
Symptoms of an overdose may include:
- Extreme sleepiness
- Loss of consciousness
- Kidney failure (no urine production)
If you think that you or someone else has overdosed, call a poison control center at 1-800-222-1222.
If you or someone else has any severe symptoms after an overdose, call 9-1-1.
Hascovir ought to be taken as early as possible after you see the very first symptoms, so it's just all-natural to have it in the house prepared to be taken when you need it a lot of. You could make it occur as long as you know a trustworthy online drug store that provides this kind of solutions and can give you top quality Hascovir with no prescription called for and with all the quality warranties you wish. Our contrast web page is there to assist you compose your thoughts in a min, as it includes just most trusted and meticulously consulted pharmacies offering Hascovir available and other drugs you might really need at any sort of point.
Hascovir needs to be taken at the exact amount suggested, without taking much more or less of it, or stopping the therapy before it's time. Hascovir treatment should be begun when feasible after the initial indications of the infection are presented (blisters, burning etc), since it will certainly be most reliable after that. It's crucial to bear in mind that although Hascovir helps to keep the signs under command, it does not treat the infection. When having sexual sex and ought to put on a condom (or make certain the condom is worn by the sex-related partner), the client stays transmittable. You could take Hascovir with some food or without, but always similarly.