Cobalat capsules


  • Active Ingredient: Nifedipine
  • 30 mg, 20 mg
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What is Cobalat?

The active ingredient of Cobalat brand is nifedipine. Nifedipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels. Nifedipine, USP is a yellow powder, practically insoluble in water but soluble in ethanol. It has a molecular weight of 346.33. Nifedipine Extended-Release Tablets, USP are formulated as a once-a-day controlled-release tablet for oral administration designed to deliver 30 mg, 60 mg or 90 mg of nifedipine. Inert ingredients in the formulations are: black iron oxide, cellulose acetate, ferric oxide, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, propylene glycol, red iron oxide, sodium chloride, talc, titanium dioxide and yellow iron oxide. Meets USP Dissolution Test 8.

Used for

Cobalat is used to treat diseases such as: Angina Pectoris Prophylaxis, Heart Failure, High Blood Pressure, Hypertensive Emergency, Hypertrophic Cardiomyopathy, Migraine Prevention, Premature Labor, Raynaud's Syndrome.

Side Effect

Possible side effects of Cobalat include: burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; pain or discomfort in the arms, jaw, back, or neck; increased urge to urinate during the night; changes in skin color; redness or other discoloration of the skin; itching; rapid weight gain.

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Why is Cobalat prescribed to patients?

Cobalat is used for the treatment and prevention of angina resulting from either an increased workload on the heart (as with exercise) or spasm of the coronary arteries. It is used in the treatment of high blood pressure, to treat abnormally fast heart rhythms such as atrial fibrillation, and in the prevention of episodes of rapid heart rhythm originating from the atria of the heart.

It also is used to dilate blood vessels that go into spasm such as those causing Raynaud's phenomenon, a painful condition of the hands caused by spasm of the arteries supplying blood to the hands.

Non-FDA approved uses include:

  • anal fissures (applied to the fissures),
  • prevention of migraineheadaches in adults,
  • ureteral stones (as secondary therapy) and
  • wound healing (applied to the skin).

Q: I recently had a contraction and I am 34 weeks pregnant, so my obstetrician gave me Cobalat 10 mg capsules. I am worried about taking any medication while I am pregnant. I was wondering if it is safe to take that medication and will it affect the baby?

A: According to drug information, Cobalat is classified as pregnancy category C, which means there are some risks associated with it. Cobalat has been shown to cross the placenta. The recommendation is to use Cobalat in pregnancy when the benefits outweigh the possible risks. It can be used in the treatment of preterm labor. My recommendation is to talk with your healthcare provider, especially your obstetrician. Keep in mind that you have been prescribed this for a reason, and even though there may be risks associated with it, you also have to consider the risks of not taking the medication. Your healthcare provider can better explain the decision making that went into choosing this medication for you. Do not stop taking the medication without talking to your physician. Jen Marsico, RPh

How should I take Cobalat?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Swallow the tablet or capsule whole and do not crush, chew, or break it.

Take the extended-release tablet on an empty stomach.

Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes.

Your blood pressure will need to be checked often and you may need other medical tests.

Keep using this medicine even if you feel well. Use all your heart or blood pressure medications as directed and read all medication guides you receive. Do not change your dose or stop taking your medicine without your doctor's advice.

You may have very low blood pressure while taking this medication. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual.

If you need surgery, tell the surgeon ahead of time that you are using Cobalat. You may need to stop using the medicine at least 36 hours before surgery.

Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.

Store in the original container at room temperature, away from moisture, heat, and light.

Serious Side Effects of Cobalat

Tell your doctor right away if you experience any of the following serious side effects:

  • More intense or more frequent chest pain
  • Fainting
  • Difficulty breathing or swallowing
  • Swelling of the eyes, face, lips, tongue, hands, arms, feet, ankles, or lower legs
  • Rash
  • Yellowing of the skin or eyes (jaundice)

Q: I have had terrible stomach nausea and aching pain in my upper abdomen since I increased my medication from 30 to 60 mg of Procardia. Could that be a side effect?

A: Procardia (Cobalat) is a calcium channel blocker used to treat high blood pressure and other heart conditions, such as angina (chest pain), as directed by your doctor. Procardia works by increasing the supply of oxygen and blood to the heart, and relaxing the blood vessels, so the heart does not have to work as hard. The most common side effects with Procardia are flushing, edema (swelling), dizziness, headache, and nausea. Other side effects with Procardia include abdominal cramps, diarrhea and constipation. This is not a complete list of the side effects associated with Procardia. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-06-22 Copyright © 2014 Everyday Health Media, LLC

Cobalat Interactions

Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking, especially:

  • Acarbose (Prandase, Precose)
  • Anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven)
  • Antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral)
  • Beta blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal), and timolol (Blocadren)
  • Carbamazepine (Carbatrol, Epitol, Tegretol)
  • Cimetidine (Tagamet)
  • Digoxin (Lanoxin, Lanoxicaps)
  • Diltiazem (Cardizem)
  • Doxazosin (Cardura)
  • Erythromycin (E.E.S., E-Mycin, Erythrocin)
  • Fentanyl (Actiq, Duragesic, Fentora, Sublimaze)
  • Flecainide (Tambocor)
  • HIV protease inhibitors including amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra)
  • Metformin (Glucophage)
  • Nefazodone (Serzone)
  • Phenobarbital (Luminal)
  • Phenytoin (Dilantin)
  • Quinidine (Quinidex)
  • Quinupristin and dalfopristin (Synercid)
  • Rifampin (Rifadin, Rifamate, Rifater, Rimactane)
  • Rifapentine (Priftin)
  • St. John’s wort
  • Tacrolimus (Prograf)
  • Valproic acid (Depakene, Depakote)
  • Verapamil (Calan, Covera, Isoptin, Verelan)

Important: a few people taking Cobalat have experienced worsening of chest pain at the start of treatment - if this happens to you, you must let your doctor know straightaway.

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

Cobalat is a dihydropyridine calcium antagonist that lowers BP by peripheral vasodilatation with only mild negative inotropic and chronotropic effects.

What if I forget to take it?

If you forget to take a dose and you usually take Cobalat:

  • 3 times a day: leave out that dose and take your next dose at the usual time.
  • twice a day: take it as soon as you remember unless it is less than 4 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time.
  • once a day: take it as soon as you remember unless it is less than 12 hours until your next dose. In this case leave out the missed dose and take your next dose at the usual time.

Never take a double dose to make up for a forgotten one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

Common Side Effects of Cobalat

Tell your doctor if any of the following side effects are severe or don’t go away:

  • Nausea
  • Headache
  • Flushing
  • Dizziness or light-headedness
  • Heartburn
  • Fast heartbeat
  • Muscle cramps
  • Cough
  • Constipation
  • Decreased sexual ability


This medication contains Cobalat. Do not take Procardia, Procardia XL, Adalat CC, Nifedical XL, Adalat, Afeditab CR, or Nifediac CC if you are allergic to Cobalat or any ingredients contained in this drug.

This medication contains Cobalat. Do not take ProAmatine or Orvaten if you are allergic to Cobalat or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Cobalat is given to treat high blood pressure (hypertension), or to help prevent angina chest pain. It is also prescribed in the treatment of Raynaud's phenomenon, which is a condition caused by poor circulation to the hands and feet. You will have been prescribed it for one of these reasons.

Missed Dose of Cobalat

If you miss a dose of Cobalat, take it as soon as you remember.

However, if it’s almost time for your next dose, skip the missed dose and continue on your regular medication schedule.

Don’t double up on doses to make up for a missed one.

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