Other uses for this medicine
Cipex is also sometimes used to treat infections caused by tapeworms. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
5.2 Inhibition of glucose uptake
Cipex interferes with glucose uptake in nematodes and cestodes. The uptake of exogenous glucose in A. suum and M. expansa is inhibited by Cipex. The inhibition of glucose transport in A. suum and T. spiralis larvae at 10 − 5 - 10 − 6 M concentration of Cipex has also been demonstrated . The blocking of glucose utilisation or its transport leads to decreased ATP synthesis causing depletion of the energy source in the worm.
Further work on the mode of action of benzimidazoles has shown that drugs of this class interfere with the energy pathway of the helminths by inhibiting both cytoplasmic and mitochondrial malate dehydrogenase (MDH) . The cytoplasmic and mitochondrial MDH obtained from A. suum, F. hepatica and M. expansa was inhibited by Cipex, while albendazole, parbendazole and thiabendazole inhibited the F. hepatica enzymes more than the enzyme from A. suum . According to McCracken and Stilwell , the benzimidazole anthelmintics may act as lipid-soluble proton conductors both in artificial (phospholipid bilayer) and natural (rat-liver mitochondria) membrane systems. These drugs disturb the transmembrane proton gradient severely, leading to a considerable drop in cellular ATP levels. The in vitro and in vivo results obtained by these authors would indicate that the mode of action of benzimidazole may be, in part, due to a bioenergetic disruption caused by transmembrane proton discharge.
Other Nematode Infections
Cipex used in conjunction with corticosteroids appeared to shorten the course of infection (but not the number of relapses) in several patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. No drug has been shown to be effective in the treatment of this infection and some patients have worsened when treated with albendazole, Cipex, thiabendazole, or invermectin. Cipex has been used in animals for the treatment of angiostrongyliasis caused by A. costaricensis or A. malaysiensis Cipex is considered the drug of choice and albendazole is considered an alternative for the treatment of capillariasis caused by Capillaria philippinensis. Although metronidazole generally is considered the drug of choice for the treatment of infections caused by Dracunculus medinensis (guinea worm) since it has been shown to decrease inflammation and facilitate removal of the worm, Cipex (400-800 mg daily for 6 days) has been reported to kill the worm directly. Cipex is used in the treatment of infections caused by Trichostrongylus. Pyrantel pamoate is considered the drug of choice and albendazole or Cipex are alternative for the treatment of Trichostrongylus infections. Cipex is considered a drug of choice for the treatment of trichuriasis caused by Trichuris trichiura (whipworm).
Urgent advice: Call 111 for advice now if:
- your child is under 2 years old and takes an extra dose of Cipex
Like all medicines, Cipex can cause side effects, although not everyone gets them.
The safety and effectiveness of VERMOX™ CHEWABLE 500 mg tablets have been established in pediatric patients 1 to 16 years of age. Use of VERMOX™ CHEWABLE 500 mg tablets in children is supported by evidence from adequate and well-controlled studies of VERMOX™ CHEWABLE 500 mg tablets .
The safety and effectiveness of Cipex, including VERMOX™ CHEWABLE have not been established in pediatric patients less than one year of age. Convulsions have been reported with Cipex use in this age group .
Do not take EMVERM if you are allergic to Cipex or any of the ingredients in EMVERM. See the end of this Patient Information for a complete list of ingredients in EMVERM.
- are pregnant or plan to become pregnant. It is not known if EMVERM will harm your unborn baby.
- are breastfeeding or plan to breastfeed. EMVERM can pass into your milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take EMVERM. Do not breastfeed while taking EMVERM.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using EMVERM with certain other medicines can change the way these medicines act, causing serious side effects. Know the medicines you take. Keep a list of them to show to your healthcare provider or pharmacist when you get a new medicine.
Before taking Cipex
To make sure this is the right treatment for you or your child, before taking Cipex it is important that your doctor or pharmacist knows:
- If you are pregnant or breast-feeding.
- If you have a baby or young child in the family. You cannot buy Cipex for use in children under 2 years old - you will need advice from a doctor.
- If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
Ordinarily, an article like this might not appeal to someone with a minimal interest in biology. But this article is about cancer. That's something that we will all experience, either personally or with someone close to us.
I'm not going to bore you with statistics or preach about unhealthy lifestyles or genetics. The fact is that we all get cancer in our lifetime -- probably many times. Our bodies usually defend against the cancerous cells and they are destroyed before they can do any damage. Unfortunately, for some people, the battle isn't so easy and the outcome unclear.
But wait. there is good news. It's a medicine that seems too good to be true, yet it is. And get this -- it costs just a couple of dollars and its in most every local pharmacy. It's anti-cancer success has been well documented in journals (which I will show you) -- even with cancers that are unresponsive to other chemotherapy. While it kills cancer cells it poses no harm to the normal cells and has little or no side effects. It's called Cipex and "Big Pharma" hopes you will never hear about it.
Cipex is administered orally. The tablets may be chewed, swallowed whole, or crushed and mixed with food. Special diets, fasting, or purgation prior to administration of the drug is not necessary. Patients should be advised of hygienic precautions needed to minimize reinfection, such as wearing shoes, washing hands with soap and cleaning under fingernails often during the day (especially before eating and after using the toilet), and washing all fruits and vegetables thoroughly before eating them.
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
- shortness of breath
- difficulty breathing or swallowing
- fever, sore throat, chills, or other signs of infection
Cipex may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Cipex ( Fig. 42-2 ) was first introduced in 1977 as a veterinary anthelmintic agent for treatment of Echinococcus multilocularis. Its mode of action is similar to other benzimidazoles. Although it has been approved for the treatment of both intestinal and tissue helminths, it is less effective than albendazole for treatment of extraintestinal helminths, and therefore, it is used almost exclusively for the treatment of common intestinal nematode infections.
There have been liver function test elevations and rare reports of hepatitis when Cipex was taken for prolonged periods and at dosages substantially above those recommended.
Storage And Handling
VERMOX ™ (Cipex) is available as 100 mg, round, flat radius-edged white to yellowish chewable tablets that are debossed with “M/100” on one side and “J” on the other side. They are supplied as follows:
Blister package of 12 tablets NDC 50580-070-12
Store at controlled room temperature 59°–77°F (15°–25°C).
Manufactured by: Janssen Pharmaceutica NV, Beerse, Belgium. Revised: June 2017
For the treatment of filariasis caused by Mansonella perstans, some clinicians recommend that adults and pediatric patients receive Cipex in a dosage of 100 mg twice daily for 30 days. For the treatment of onchocerciasis (filariasis caused by Onchocerca volvulus) in adults, a Cipex dosage of 1 g twice daily for 28 days has been suggested.
There is a potential for development of resistance to Cipex. The mechanism of resistance to Cipex is likely due to changes of beta-tubulin protein, which reduces binding of Cipex to beta-tubulin; however, the clinical significance of this is not known.
Yes, in the European countries Cipex can be found on the supermarket shelves.
Cipex is an anthelmintic drug that has been used since the early 1970s to treat a range of parasitical worm infections, including threadworm, tapeworms, roundworms, and other nematode and trematode infections in humans and domestic animals (Ref.). The drug is among those on the World Health Organization’s list (WHO) (Ref.).
Cipex became and remained one of my preferred drugs since I learned about it at the beginning of 2014. This was mainly due to the multiple strong points that are defining Cipex. Those strong points are: