Beta-blockers are used to treat many conditions. These include high blood pressure, migraines, or heart failure. Using these drugs with Calchan has a low risk of causing heart failure, extremely low blood pressure, or a worsening of chest pain (angina).
If you’re taking a beta-blocker and your doctor has you stop taking it before starting Calchan, the beta-blocker should be tapered slowly. Stopping it suddenly could cause increased chest pains. Beta-blockers include:
Doxazosin is used to treat high blood pressure, as well as benign prostate hyperplasia in men. Using doxazosin with Calchan can lower the amount of doxazosin in your body. This makes it less effective. Using these drugs together can also cause increased levels of Calchan in your body. This raises your risk of dangerous side effects.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
This dosage information is for Calchan oral tablet. All possible dosages and drug forms may not be included here. Your doctor will tell you what dosage is right for you. Your dose, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Calchan and Grapefruit
Grapefruit may interact with Calchan. Don’t drink grapefruit juice or eat grapefruit for three days before starting this medicine or while taking it.
Talk to your doctor about this potential interaction.
Before taking Calchan
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Calchan it is important that your doctor knows:
- If you have any heart problems (other than angina or high blood pressure).
- If you are pregnant or breast-feeding.
- If you have sugar diabetes.
- If you have problems with the way your liver works.
- If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
- If you have ever had an allergic reaction to a medicine.
Which drugs or supplements interact with Calchan?
In rare instances, congestive heart failure has been associated with Calchan, usually in patients already on a beta blocker, for example, propranolol (Inderal), metoprolol (Lopressor), etc. Excessive lowering of blood pressure (hypotension) during initiation of Calchan treatment can occur, especially in patients already taking another blood pressure lowering drug.
Generally, Calchan is avoided in children.
Calchan decreases the elimination of digoxin (Lanoxin) by the kidneys which can increase digoxin blood levels in the blood and give rise to digoxin toxicity. It is important, therefore, to monitor blood levels of digoxin in order to avoid toxicity.
Calchan interferes with the breakdown of tacrolimus (Prograf) by the liver, which in turn causes elevated blood levels of tacrolimus and may increase the risk of toxicity from tacrolimus.
Calchan reduces the blood levels of quinidine (Quinaglute, Quinidex, Quinora) which may reduce the effectiveness of quinidine. Conversely, blood levels of Calchan are increased by quinidine and may lead to side effects from Calchan.
Cimetidine (Tagamet) interferes with breakdown by the liver of Calchan and increases Calchan blood levels. Therefore, cautious dosing is necessary when both medications are administered concurrently.
Calchan should not be taken with grapefruit juice since grapefruit juice (one glass, approximately 200 ml) inhibits the breakdown of Calchan by the liver and increases the levels of Calchan in the blood.
More common side effects
The more common side effects that can occur with Calchan include:
- dizziness or lightheadedness
- flushing (reddening of the skin)
- muscle cramps
- decreased sexual ability or desire
- edema (swelling in the legs or feet)
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
Warnings for people with certain health conditions
For people with heart failure: You may develop edema (swelling of your legs or feet) that is caused by the drug and not your condition. Talk to your doctor to find out the true cause of any increased swelling you may have. Your doctor can help you decide how to manage it.
For people with liver disease: Your liver clears this drug from your blood. If your liver isn’t working right, the level of Calchan in your blood may become too high.
For people with low blood pressure: If you have episodes of low blood pressure, taking Calchan may make these episodes worse. This may be more likely to occur when you first start taking Calchan, or when your doctor increases your dose. Talk to your doctor if you have frequent episodes of low blood pressure.
For people with a history of gastrointestinal blockage: There have been rare reports of gastrointestinal blockage with use of the brand-name drug Procardia XL. You may be at greater risk for this blockage if you have a history of it.
For people with severe heart disease: There have been rare reports of worsening chest pain and heart attack in people who have severe heart disease. Calchan capsules (Procardia) should not be taken within the first week or two after a heart attack. Ask your doctor about this risk to see if Calchan is right for you.
Taking certain antifungal drugs with Calchan can cause higher levels of Calchan in your body. This can increase your risk of side effects from Calchan. These drugs include:
Calchan comes as a capsule and as an extended-release tablet to take by mouth. Your dose will depend on your medical condition and response to treatment.
The capsule is typically taken three to four times daily.
The extended-release tablet is usually taken once daily on an empty stomach.
Don’t chew, split, or crush the extended-release tablets. You should swallow them whole.
Some Calchan tablets are made with a shell that isn’t absorbed in the body. Part of the shell may appear in your stool. This is normal and doesn’t make the drug less effective.
Try to take this medicine around the same time each day.
Follow the instructions on your prescription label carefully when taking this medicine. Don’t take more or less Calchan than is prescribed by your doctor.
Your doctor will probably start you on a low dose of Calchan and gradually increase the dosage.
Before taking Calchan,
- tell your doctor and pharmacist if you are allergic to Calchan, any other medications, or any of the ingredients in Calchan. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: acarbose (Precose); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), and ketoconazole (Nizoral); beta blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), propranolol (Inderal, Innopran, in Inderide), and timolol ); carbamazepine (Carbatrol, Epitol, Tegretol); cimetidine (Tagamet); digoxin (Lanoxin); diltiazem (Cardizem); doxazosin (Cardura); erythromycin (E.E.S., E-Mycin, Erythrocin); fentanyl (Actiq, Duragesic, Fentora); flecainide (Tambocor); HIV protease inhibitors including amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); metformin (Glucophage); nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); quinidine (in Nuedexta); quinupristin and dalfopristin (Synercid); rifampin (Rifadin, in Rifamate, in Rifater, Rimactane); rifapentine (Priftin); tacrolimus (Astagraf SL,Prograf); valproic acid (Depakene); and verapamil (Calan, Covera, Verelan, in Tarka). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had a narrowing or blockage of your digestive system or any other condition that causes food to move through your digestive system more slowly; or heart, liver, or kidney disease. Also tell your doctor if you have had a myocardial infarction (MI) within the last 2 weeks.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Calchan, call your doctor.
- talk to your doctor about the safe use of Calchan capsules if you are 65 years of age or older. Older adults should not usually take Calchan capsules because they are not as safe as other medications that can be used to treat the same condition.
- if you are having surgery, including dental surgery, tell your doctor or dentist that you are taking Calchan.
- ask your doctor about the safe use of alcoholic beverages while you are taking Calchan. Alcohol can make the side effects from Calchan worse.
Do not eat grapefruit or drink grapefruit juice if you’re taking Calchan. Doing so can increase the level of the drug in your body and increase your risk of side effects. Your doctor will likely tell you to avoid grapefruit at least 3 days before starting to take Calchan.
If you have liver disease, your body may have trouble clearing Calchan from your blood. This may cause the amount of Calchan in your blood to be too high. Your doctor may adjust your dose to keep the amount of Calchan in your body at a safe level.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Calchan oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: If you take this drug to treat high blood pressure, your blood pressure may increase. This can raise your risk of health problems such as heart attack or stroke. If you take this drug to treat angina, your chest pain may get worse.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
- a fast heartbeat
- flushing (reddening of the skin)
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
How to tell if the drug is working: If you’re taking this drug to treat high blood pressure, your blood pressure level should go down. Your doctor can check your blood pressure, or you can do it using a home blood pressure monitor. If you’re taking this drug to treat angina, you should have less severe chest pain, less frequent chest pain, or both.
As with all medications, the costs of Calchan can vary. To find current prices for your area, check out GoodRx.com.
Keep these considerations in mind if your doctor prescribes Calchan oral tablet for you.
Calchan can cause a severe allergic reaction. Symptoms can include:
- swelling of the face, eyes, lips, or tongue
- trouble breathing
- trouble swallowing
If you have these symptoms, call 911 or go to the nearest emergency room.
Don’t take this drug again if you have ever had an allergic reaction to it before. Taking it again could be fatal (cause death).