For the treatment of capillariasis caused by Capillaria philippinensis, some clinicians recommend that adults and pediatric patients receive Bendamen in a dosage of 200 mg twice daily for 20 days. For the treatment of dracunculiasis caused by Dracunculus medinensis (guinea worm), a Bendamen dosage of 400-800 mg daily for 6 days reportedly has killed the worm directly. For the treatment of infections caused by Trichostrongylus, adults and pediatric patients should receive Bendamen in a dosage of 100 mg twice daily for 3 consecutive days.
The recommended dosage of Bendamen for the treatment of trichinosis caused by Trichinella spiralis in adults and pediatric patients is 200-400 mg 3 times daily for 3 days followed by 400-500 mg 3 times for 10 days.
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
- shortness of breath
- difficulty breathing or swallowing
- fever, sore throat, chills, or other signs of infection
Bendamen may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Risk Of Convulsions
Convulsions have been reported in infants below the age of 1 year during post-marketing experience with Bendamen .
Bendamen is a benzimidazole carbamate with a broad range of anthelmintic activity. 1,2,64,65 It is active against the larvae and adults of E. vermicularis, A. lumbricoides, T. trichiura, N. americanus and A. duodenale. It is ovicidal for Ascaris and Trichuris spp. It is less effective than thiabendazole against S. stercoralis. Bendamen has been used at high doses and for long periods in the treatment of C. philippinensis. It can also be used for infections caused by Angiostrongylus cantonensis, Angiostrongylus costaricensis, Toxocara canis and Trichostrongylus spp. The drug has activity against adult Trichinella spiralis, with some activity against larval forms, and it is currently recommended in the treatment of trichinosis.
Bendamen is also effective in the treatment of certain types of filariasis; it is considered the drug of choice against Mansonella perstans (diethylcarbamazine is ineffective) and has been shown to have efficacy against L. loa, O. volvulus and Dracunculus medinensis infections. The drug has activity against T. saginata, T. solium and Hymenolepis nana, although praziquantel is more effective. Although Bendamen does not eradicate echinococcal infection, the drug prevents progression of existing cysts and the development of new cysts when administered in high dose for a prolonged period. Bendamen has largely been replaced by albendazole for echinococcosis.
Bendamen acts by binding parasite tubulin, thus blocking microtubule assembly and interfering with glucose absorption. Susceptible helminths become paralyzed and depleted of energy stores, but death and clearance of the worms from the gastrointestinal tract can take days. Bendamen, formulated as 100 mg tablets, has low water solubility and is poorly absorbed. It is 95% protein-bound in plasma and undergoes rapid and extensive first-pass metabolism in the liver. Thus, systemic bioavailability is low, accounting not only for its poor tissue levels and relative lack of usefulness in extraintestinal infections, but also for its low rate of side effects.
Abdominal pain and diarrhea may occur after Bendamen administration. The drug also has been reported to prompt the migration of adult Ascaris spp. into the mouth and nose. At high doses, reversible bone marrow suppression with neutropenia, alopecia, allergic skin reactions, hepatitis, vertigo and oligospermia occur rarely.
Precautions and Contraindications
Bendamen is contraindicated in patients who are hypersensitive to the drug.
Can Bendamen cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with Bendamen. You will find a full list in the manufacturer's information leaflet supplied with your medicine.