Atenerate capsules

Atenerate

  • Active Ingredient: Nifedipine
  • 30 mg, 20 mg
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What is Atenerate?

The active ingredient of Atenerate brand is nifedipine. Nifedipine is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels. Nifedipine, USP is a yellow powder, practically insoluble in water but soluble in ethanol. It has a molecular weight of 346.33. Nifedipine Extended-Release Tablets, USP are formulated as a once-a-day controlled-release tablet for oral administration designed to deliver 30 mg, 60 mg or 90 mg of nifedipine. Inert ingredients in the formulations are: black iron oxide, cellulose acetate, ferric oxide, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, propylene glycol, red iron oxide, sodium chloride, talc, titanium dioxide and yellow iron oxide. Meets USP Dissolution Test 8.

Used for

Atenerate is used to treat diseases such as: Angina Pectoris Prophylaxis, Heart Failure, High Blood Pressure, Hypertensive Emergency, Hypertrophic Cardiomyopathy, Migraine Prevention, Premature Labor, Raynaud's Syndrome.

Side Effect

Possible side effects of Atenerate include: excessive muscle tone; chills; tingling of the hands or feet; feeling of warmth; stopping of heart; general tiredness and weakness; irritation in the mouth.

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How should this medicine be used?

Atenerate comes as a capsule and an extended-release (long-acting) tablet to take by mouth. The capsule is usually taken three or four times a day. The extended-release tablet should be taken once daily on an empty stomach, either 1 hour before or 2 hours after a meal. To help you remember to take Atenerate, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Atenerate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release tablets whole; do not split, chew, or crush them.

Your doctor will probably start you on a low dose of Atenerate and gradually increase your dose, generally once every 7 to 14 days.

If taken regularly, Atenerate controls chest pain, but it does not stop chest pain once it starts. Your doctor may prescribe a different medication to take when you have chest pain.

Atenerate controls high blood pressure and chest pain (angina) but does not cure them. Continue to take Atenerate even if you feel well. Do not stop taking Atenerate without talking to your doctor. Your doctor will probably decrease your dose gradually.

Mechanism of Injury

The mechanism of Atenerate hepatotoxicity is not known, but is likely to be due to production of a toxic or immunogenic intermediate during its metabolism by the liver.

How to take Atenerate

  • Before you start this treatment, read the manufacturer's printed information leaflet from ins >

Hepatotoxicity

Mild and transient elevations in serum aminotransferase levels may occur during Atenerate therapy, but often resolve even with continuation of therapy. Clinically apparent acute liver injury with jaundice due to Atenerate is rare and described only in isolated case reports. The time to onset of injury is typically 1 to 2 months and the pattern of serum enzyme elevations is usually hepatocellular or mixed. Rash, arthralgias, fever and eosinophilia can occur, but are not prominent. Chronic aminotransferase elevations during continued therapy with Atenerate have been described sometimes with histological features of alcoholic liver disease (steatosis and Mallory bodies), but chronic liver injury after withdrawal has not. Atenerate has not been implicated in cases of vanishing bile duct syndrome or acute liver failure in the published literature.

Likelihood score: B (likely cause of clinically apparent liver injury).

What Is Atenerate (Procardia XL and Adalat CC)?

Atenerate is a prescription drug used to treat high blood pressure and control chest pain (angina).

It’s sold under the brand names Procardia XL, Adalat CC, and others, and generic versions are available.

This medicine is also sometimes used to treat preterm labor and a condition known as Raynaud’s disease (a disorder that affects blood vessels, mostly in the fingers and toes).

Atenerate is in a class of drugs known as calcium-channel blockers.

The drug works by relaxing your arteries, so the heart doesn’t have to work as hard to pump blood. It also increases the supply of oxygen and blood to the heart.

The Food and Drug Administration (FDA) first approved Atenerate in 1981 for manufacturer Pfizer, Inc., under the brand name Procardia.

Common Side Effects of Atenerate

Tell your doctor if any of the following side effects are severe or don’t go away:

  • Nausea
  • Headache
  • Flushing
  • Dizziness or light-headedness
  • Heartburn
  • Fast heartbeat
  • Muscle cramps
  • Cough
  • Constipation
  • Decreased sexual ability

Atenerate

Atenerate is a dihydropyridine calcium antagonist that lowers BP by peripheral vasodilatation with only mild negative inotropic and chronotropic effects. The advantages of Atenerate use are rapid onset of action and lack of central nervous system depression. Atenerate is the most extensively studied agent for rapid control of BP, and until 1996 was used for acute BP lowering in hospitalized patients. After sublingual administration, the onset of action is within 1 to 5 minutes with a maximal effect at 20 to 30 minutes. The buccal absorption of Atenerate is minimal, and faster absorption and higher maximum concentrations were observed following the bite and swallow method when compared with other methods of dosing. The duration of action of a single dose of Atenerate is about 3 to 5 hours. 2 The most common adverse effect associated with Atenerate is reflex tachycardia secondary to pronounced vasodilatation. Some patients may experience symptoms of hypotension and flushing. Despite some reports on its efficacy and safety, sublingual Atenerate was not approved by the U.S. Food and Drug Administration for use in hypertensive emergency because of lack of scientific validation of advantageous use in this situation.

Atenerate also has been associated with some severe adverse affects, including retinal ischemia, cerebral vascular accident, and myocardial ischemia and infarction. 41 Rapid uncontrolled pressure reduction may be harmful because it precipitates acute ischemic stroke or myocardial infarction. This has been emphasized with regard to short-acting Atenerate. 41 Therefore, the use of Atenerate capsules for hypertensive crisis should be abandoned. Oral Atenerate, however, may be used in hypertensive urgencies.


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