What should I avoid?
Grapefruit and grapefruit juice may interact with Aprical and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Aprical only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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More common side effects
The more common side effects that can occur with Aprical include:
- dizziness or lightheadedness
- flushing (reddening of the skin)
- muscle cramps
- decreased sexual ability or desire
- edema (swelling in the legs or feet)
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
6. How to cope with s >
What to do about:
- headaches - make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller for a headache. Paracetamol is safe to take with Aprical. Headaches should usually go away after the first week of taking Aprical. Talk to your doctor if they last longer than a week or are severe.
- feeling dizzy - if Aprical makes you feel dizzy, stop what you're doing and sit or lie down until you feel better.
- flushing - try cutting down on coffee, tea and alcohol. It might help to keep the room cool and use a fan. You could also spray your face with cool water or sip cold or iced drinks. The flushing should go away after a few days, so try to carry on taking Aprical for this time. If it does not go away or is causing you problems, contact your doctor.
- a pounding heartbeat - if this happens regularly after you take your medicine try to take it at a time when you can sit or lie down while the symptoms are at their worst. It might also help to cut down on alcohol, smoking, caffeine and big meals as these can make the problem worse. If you are still having problems after a week or so speak to your doctor as they may need to change you to a different type of medicine.
- swollen ankles - raise your legs when you're sitting down.
- constipation - eat plenty of high-fibre foods such as fresh fruit and vegetables and cereals, and drink lots of water. Try to exercise regularly, for example by going for a daily walk or run. It's ok to occasionally use a laxative.
4. How and when to take it
Take Aprical exactly as your doctor has told you, and follow the directions on the label. If you're not sure, check with your doctor or pharmacist.
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Aprical.
Aprical (nye fed' i peen) belongs to the dihydropyridine class of calcium channel blockers (first in its class and similar to amlodipine, felodipine and nicardipine) and is used for the treatment of hypertension and angina pectoris. Like other calcium channel blockers, Aprical acts by inhibiting the transmembrane influx of calcium into cardiac and smooth muscle cells during depolarization. The inhibition of calcium influx causes arterial vasodilation and decreases cardiac work and oxygen consumption. Aprical was approved in the United States in 1982 and currently several million prescriptions are filled yearly. Current indications include hypertension and chronic stable and Prinzmetal's variant angina pectoris. It is also used off label to treat Raynaud phenomenon. Aprical is available in capsules of 10 and 20 mg and as extended release tablets of 30, 60 and 90 mg in several generic formulations as well as under brand names including Procardia, Adala, Afeditab, Nifediac, and Nifedical. The typical dose in adults is 30 to 60 mg daily, usually starting with lower doses. Aprical is generally well tolerated and side effects are largely due to its vasodilating activities and can include dizziness, flushing, headache, fatigue, nausea, diarrhea, palpitations, bradycardia, peripheral edema and skin rash.
Pharmacologic class: Calcium channel blocker
Therapeutic class: Antianginal, anti-hypertensive
Pregnancy risk category C
If you have liver disease, your body may have trouble clearing Aprical from your blood. This may cause the amount of Aprical in your blood to be too high. Your doctor may adjust your dose to keep the amount of Aprical in your body at a safe level.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Aprical oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: If you take this drug to treat high blood pressure, your blood pressure may increase. This can raise your risk of health problems such as heart attack or stroke. If you take this drug to treat angina, your chest pain may get worse.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
- a fast heartbeat
- flushing (reddening of the skin)
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.
How to tell if the drug is working: If you’re taking this drug to treat high blood pressure, your blood pressure level should go down. Your doctor can check your blood pressure, or you can do it using a home blood pressure monitor. If you’re taking this drug to treat angina, you should have less severe chest pain, less frequent chest pain, or both.
As with all medications, the costs of Aprical can vary. To find current prices for your area, check out GoodRx.com.
Keep these considerations in mind if your doctor prescribes Aprical oral tablet for you.
Can Aprical cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Aprical. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
What is the most important information I should know about Aprical?
You may not be able to use this medicine if your heart cannot pump blood properly, or if you also take rifampin.
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
How to take Aprical
- Before you start this treatment, read the manufacturer's printed information leaflet from ins >
What special dietary instructions should I follow?
Do not drink grapefruit juice or eat grapefruit 3 days before and while taking Aprical.
If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.
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Other drugs in the same class as Aprical include:
Like other CCBs, Aprical works by blocking the flow of calcium into the muscle cells surrounding the arteries that supply blood to the heart (coronary arteries) as well as other arteries of the body. Since the inflow of calcium is what causes the muscle cells to contract, blocking the entry of calcium relaxes the muscles and dilates (widens) the arteries. By dilating coronary arteries, Aprical increases the flow of blood to the heart. This treats and prevents angina which occurs when the flow of blood to the heart is not adequate to supply the heart with enough oxygen necessary to pump blood. Relaxing the muscles surrounding other arteries of the body lowers blood pressure and thereby reduces the pressure against which the heart must pump blood and function. This reduces the demand of the heart for oxygen--another mechanism by which CCBs treat and prevent angina. In addition, Aprical slows conduction of the electrical current that travels through the heart that causes the muscle of the heart to contract. This effect can be used to correct abnormally rapid heartbeats.
What are the possible side effects of Aprical?
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Call your doctor at once if you have:
- worsening chest pain;
- pounding heartbeats or fluttering in your chest;
- a light-headed feeling, like you might pass out;
- swelling in your hands or lower legs; or
- upper stomach pain, jaundice (yellowing of the skin or eyes).
You may have more severe or more frequent episodes of angina when you first start taking Aprical or whenever your dose is changed.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
7. Pregnancy and breastfeeding
If you're trying to get pregnant or you're already pregnant, talk to your doctor about the benefits and possible harms of taking Aprical. There may be other medicines that are safer for you.
For more information about how Aprical can affect you and your baby during pregnancy, visit the Best Use of Medicines in Pregnancy (BUMPS) website.
tablet, extended release
Not FDA approved for children
Potential toxic dose in children Enter a drug name and Aprical