Actidas

Actidas

  • Active Ingredient: Acyclovir
  • 800 mg, 400 mg, 200 mg
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What is Actidas?

The active ingredient of Actidas brand is acyclovir. Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus in the body. Acyclovir will not cure herpes, but it can lessen the symptoms of the infection. The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared with VZV is due to its more efficient phosphorylation by the viral TK.

Used for

Actidas is used to treat diseases such as: Cold Sores, Herpes Simplex, Herpes Simplex - Congenital, Herpes Simplex Encephalitis, Herpes Simplex, Mucocutaneous/Immunocompetent Host, Herpes Simplex, Mucocutaneous/Immunocompromised Host, Herpes Simplex, Suppression, Herpes Zoster, Infectious Mononucleosis, Mononucleosis, Ramsay Hunt Syndrome, Varicella-Zoster.

Side Effect

Possible side effects of Actidas include: mood or mental changes; dizziness or feeling faint, severe; loss of appetite; nausea or vomiting; changes in facial skin color; hives.

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Actidas

Actidas must be taken at the specific dose suggested, without taking basically of it, or stopping the therapy before it's time. Actidas procedure ought to be started as quickly as feasible after the very first indications of the infection are presented (scorchings, burning etc), due to the fact that it will certainly be most reliable then. It's essential to consider that although Actidas helps to keep the signs controlled, it does not cure the infection. When having sexual intercourse and needs to wear a prophylactic (or make certain the condom is used by the sex-related companion), the patient stays infectious. You could take Actidas with some meals or without, but always similarly.

Subchronic Oral Toxicity Study

Four groups each consisting of 28 male and 28 female Charles River CD-1 (ICR) mice were orally dosed by stomach tube for 33 days with suspensions of Actidas. Daily dose levels were 0, 50, 150 and 450 mg/kg. Hematology and clinical chemistry measurements were made on an additional 8 male and 8 female mice per group (dosed in the same manner) after the first and fourth weeks of dosing and during the 3rd postdose week.

Plasma drug concentrations were measured in pooled samples from an additional 4 male and 4 female mice per group on dose days 1, 15 and 30.

Based on preliminary experiments with rats and mice, the high dose of 450 mg/kg was selected to produce the highest drug plasma levels attainable, in a practical manner, by oral dosing in a rodent species. Averaged drug plasma concentrations ranged from approximately 3.4 (at the low dose) to 11.0 (at the high dose) μg/mL of plasma one hour after oral dosing.

No changes in health, growth rate, hematology and clinical chemistry measurements occurred that could be definitely attributed to dosing with Actidas. Gross and histopathologic examinations of 16 male and 16 female rats from the high-dose and control groups at the end of the dose period revealed nothing remarkable.

Nursing Mothers

Actidas concentrations have been documented in breast milk in 2 women following oral administration of ZOVIRAX (Actidas) and ranged from 0.6 to 4.1 times corresponding plasma levels. These concentrations would potentially expose the nursing infant to a dose of Actidas up to 0.3 mg/kg/day. ZOVIRAX (Actidas) should be administered to a nursing mother with caution and only when indicated.

Long-term administration: The most frequent adverse events reported in a clinical trial for the prevention of recurrences with continuous administration of 400 mg (two 200 mg capsules) 2 times daily are listed in Table 2.

Table 2 : Adverse Reactions Reported in a Clinical Trial for the Prevention of Recurrences of Genital Herpes with Actidas

Evidence so far from clinical trials suggests that the severity and frequency of adverse events is unlikely to necessitate discontinuation of therapy.

Adverse Drug Reaction Overview

The most frequent adverse reactions associated with the use of ZOVIRAX® (Actidas) are headache and nausea.

Neurological side effects have also been reported in rare instances. Elderly patients and patients with a history of renal impairment are at increased risk of developing these effects. In the reported cases, these reactions were generally reversible on discontinuation of treatment (see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS, Post-Market Adverse Drug Reactions).

Q: What are the side effects of Actidas?

A: The most frequently reported side effects of Actidas (Zovirax), for oral administration, differed in clinical trials depending on the indication for use. During clinical trials of treatment of genital herpes, with short-term administration of Actidas, the most frequently reported adverse reactions included nausea and/or vomiting. During clinical trials of treatment with long-term administration with Actidas for genital herpes, there were two methods of administration evaluated. In trials evaluating continuous administration to prevent recurrences, the most frequently reported adverse reactions included nausea and diarrhea and in those evaluating intermittent treatment of recurrences over one year diarrhea, nausea and headache were reported. The most frequently reported adverse reaction during clinical trials of shingles was malaise. Lastly, during clinical trials of treatment of chickenpox with Actidas, the most frequently reported adverse reaction was diarrhea. More serious side effects of Actidas are possible with treatment. Kidney failure, in some cases causing death, has been reported with Actidas treatment. Patients are advised to maintain adequate hydration and drink plenty of water while taking Actidas to keep the kidneys working properly. There is also a warning regarding thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), which has occurred in immunocompromised patients administered Actidas. Patients should be advised to contact their health care provider immediately if they experience symptoms which may indicate the occurrence of more serious side effects of Actidas. Symptoms may include pain the lower back, urinating less than usual or not urinating at all, easy bruising or bleeding, and unusual weakness. Patients are instructed to consult with their health care provider if they experience any other unusual, severe or troublesome side effects while being treated with Actidas.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Actidas only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 5.08.

Actidas ought to be taken as early as possible after you see the very first symptoms, so it's just all-natural to have it in the house prepared to be taken when you need it a lot of. You could make it occur as long as you know a trustworthy online drug store that provides this kind of solutions and can give you top quality Actidas with no prescription called for and with all the quality warranties you wish. Our contrast web page is there to assist you compose your thoughts in a min, as it includes just most trusted and meticulously consulted pharmacies offering Actidas available and other drugs you might really need at any sort of point.

Actidas needs to be taken at the exact amount suggested, without taking much more or less of it, or stopping the therapy before it's time. Actidas treatment should be begun when feasible after the initial indications of the infection are presented (blisters, burning etc), since it will certainly be most reliable after that. It's crucial to bear in mind that although Actidas helps to keep the signs under command, it does not treat the infection. When having sexual sex and ought to put on a condom (or make certain the condom is worn by the sex-related partner), the client stays transmittable. You could take Actidas with some food or without, but always similarly.

General

  • Take this drug at the time(s) recommended by your doctor.
  • You can take Actidas with or without food. Taking it with food may help reduce upset stomach.
  • Do not cut or crush this medication.
  • Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Actidas ought to be taken as quickly as possible after you see the very first symptoms, so it's just organic to have it in your home all set to be taken when you require it a lot of. You can make it happen as long as you understand a dependable online drug store that provides this type of services and could give you excellent quality Actidas without prescription needed and with all the quality guarantees you want. Our comparison page exists to help you make up your mind soon, as it consists of only most reliable and very carefully examined pharmacies supplying Actidas for sale and any various other medicines you may require at any point.

There were no signs of toxicosis in Charles River CD-1 (ICR) mice (115 mice/sex/dose group) given Actidas by oral gavage at 50, 150 and 450 mg/kg/day in a lifetime oral carcinogenicity study. Mean plasma levels obtained in high-dose males 1.5 hours after dosing at various sampling times during the study were as follows: 2.83, 3.17 and 1.82 μg/mL (12.59, 14.10 and 8.10 μM) at days 90, 365 and 541, respectively. Corresponding mean values for the high-dose females were 9.81, 5.85 and 4.0 μg/mL (43.60, 26.0 and 17.79 μM).

Values for clinical laboratory tests including hematology, body weight and food consumption were all within normal ranges. There were no drug-induced gross or microscopic lesions. Female mice given 150 and 450 mg/kg Actidas survived significantly longer than control female mice; survival of treated males was comparable to survival of control males. Patterns of tumor incidence and tumor counts for benign or malignant neoplasms were not affected by treatment with Actidas.

Drug Substance

Proper name: Actidas

Chemical name: 9-guanine

Other name: acycloguanosine

Molecular mass: 225.2 Structural formula:

Physicochemical properties: Actidas is a white, crystalline powder with a maximum solubility in water of 1.3 mg/mL at 25°C.

Q: Are there any Actidas interactions with other medications?

A: There are not many Actidas (Zovirax) interactions with other medications. If Actidas interacts with certain other medications, the effects can be increased, decreased or altered. One Actidas interaction possible is with the medication probenecid (Benemid). It is especially important for patients taking probenecid to consult with a health care provider prior to treatment with Actidas. If you are currently taking probenecid, you may not be able to take Actidas, or you may require dosage adjustments of special tests during treatment. Some of the other possible Actidas interactions with other medications may include Demerol (meperidine), Dilantin (phenytoin), Cellcept (mycophenolate mofetil), Viread (tenofovir), Zanaflex (tizanidine), Depakene (valproic acid), Retrovir (zidovudine), theophyllines and the varicella virus vaccine. It is essential for patients to consult with their health care provider regarding all prescription and over the counter medications they take prior to initiation of treatment with Actidas to avoid potentially dangerous drug interactions. This includes all vitamins, minerals, herbal supplements and any drugs prescribed by another doctor.

Forms and strengths

Generic: Actidas

  • Form: oral tablet
  • Strengths: 400 mg, 800 mg

Brand: Zovirax

  • Form: oral tablet
  • Strengths: 400 mg, 800 mg

PATIENT INFORMATION

Patients are instructed to consult with their physician if they experience severe or troublesome adverse reactions, they become pregnant or intend to become pregnant, they intend to breastfeed while taking orally administered ZOVIRAX (Actidas) , or they have any other questions.

Patients should be advised to maintain adequate hydration.

  • Children who weigh 40 kg (88 lbs) or less: 20 mg/kg of body weight, given four times per day for 5 days
  • Children who weigh more than 40 kg: 800 mg four times per day for 5 days

Start this drug as soon as the first symptom of chickenpox appears. It isn't known if this drug is effective if your child starts it more than 24 hours after the first sign of chickenpox.

Child dosage (ages 0–1 years)

It hasn't been confirmed that Actidas is safe and effective for children younger than 2 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.


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