Aciklovir

Aciklovir

  • Active Ingredient: Acyclovir
  • 800 mg, 400 mg, 200 mg
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What is Aciklovir?

The active ingredient of Aciklovir brand is acyclovir. Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus in the body. Acyclovir will not cure herpes, but it can lessen the symptoms of the infection. The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared with VZV is due to its more efficient phosphorylation by the viral TK.

Used for

Aciklovir is used to treat diseases such as: Cold Sores, Herpes Simplex, Herpes Simplex - Congenital, Herpes Simplex Encephalitis, Herpes Simplex, Mucocutaneous/Immunocompetent Host, Herpes Simplex, Mucocutaneous/Immunocompromised Host, Herpes Simplex, Suppression, Herpes Zoster, Infectious Mononucleosis, Mononucleosis, Ramsay Hunt Syndrome, Varicella-Zoster.

Side Effect

Possible side effects of Aciklovir include: bruising at the place of injection; large hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; swollen, painful, or tender lymph nodes (glands) in neck, armpit, or groin; blurred vision; dizziness or feeling faint, severe.

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Aciklovir Interactions

Some drugs may affect the way Aciklovir works, and Aciklovir may affect other drugs you are taking.

It's very important to let your doctor know about all drugs you are taking, including any over-the-counter herbs or supplements.

Drugs that may interact with Aciklovir include:

  • Several medications used to treat bacterial or fungal infections, including amphotericin B (Fungizone) and several antibiotics such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex) and tobramycin (Tobi, Nebcin)
  • Over-the-counter pain relievers (Advil, Motrin, Aleve)
  • Medications used to treat HIV/AIDS, such as zidovudine (Retrovir, AZT)

Generic Name: Aciklovir (oral) (a SYE klo veer)Brand Names: Sitavig, Zovirax

Medically reviewed by Sophia Entringer, PharmD Last updated on Jan 4, 2019.

Why is this medication prescribed?

Aciklovir is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and first-time or repeat outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time). Aciklovir is also sometimes used to prevent outbreaks of genital herpes in people who are infected with the virus. Aciklovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body. Aciklovir will not cure genital herpes and may not stop the spread of genital herpes to other people.

Other Aciklovir Interactions

You do not need to change your diet or your activities while on Aciklovir.

However, drink plenty of fluids when taking this medication.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to Aciklovir.

Do not let anyone else take or use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Highlights for Aciklovir

  1. Aciklovir oral tablet is available as both a generic and a brand-name drug. Brand name: Zovirax.
  2. Aciklovir is also available as a capsule, suspension, and buccal tablet you take by mouth. It also comes in a cream and ointment you apply to your skin. In addition, Aciklovir is available as an intravenous (IV) drug, which is only given by a healthcare prov >

Aciklovir oral tablet is a prescription drug that's available as the brand-name drug Zovirax. It's also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Aciklovir also comes as an oral capsule, oral suspension, buccal tablet, topical cream, and topical ointment. In addition, Aciklovir is available as an intravenous drug, which is only given by a healthcare provider.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

What Is Aciklovir (Zovirax)?

Aciklovir is the generic name for Zovirax, a prescription medication used to treat certain virus infections.

The Food and Drug Administration (FDA) approved Aciklovir to treat viral infections from the varicella virus that causes chicken pox and shingles, as well as infections from the virus that causes genital herpes.

Sometimes doctors prescribe Aciklovir to treat herpes infections in people with HIV.

The drug works by preventing viruses from dividing and multiplying. The FDA approved Aciklovir in the 1980s.

Aciklovir is available as a generic, made by several companies, or under the brand name Zovirax, made by GlaxoSmithKline and available in tablet, capsule, and liquid form.

Aciklovir is one of the oldest drugs used to treat herpes simplex viruses and remains the first line of treatment for these infections.

However, research shows that Aciklovir is not as effective as it used to be.

A 2013 study, published in the journal Current Opinion in Infectious Diseases, found that Aciklovir-resistant herpes strains could develop over time.

Resistance happens in people with a healthy immune system as well as in those with a weakened immune system.

Important information

Take Aciklovir for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.

Treatment with Aciklovir should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Herpes infections are contagious and you can infect other people, even while you are being treated with Aciklovir. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Renal impairment (IV)

  • CrCl 25-50 mL/min/1.73 m²: Give recommended dose q12hr
  • CrCl 10-25 mL/min/1.73 m²: Give recommended dose q24hr
  • CrCl Enter a drug name and Aciklovir

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Aciklovir only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 5.08.

Aciklovir S >

The most common side effects of Aciklovir treatment for genital herpes include nausea, vomiting, and diarrhea.

Shingles requires treatment with higher doses of Aciklovir, and the most common side effects at higher doses are tiredness and malaise.

Tell your doctor if you have any side effects. Side effects that may be seen in all people using Aciklovir include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Headache
  • Dizziness
  • Tiredness
  • Muscle or joint aches
  • Visual changes
  • Fluid retention
  • Hair loss
  • Confusion
  • Changes in behavior

Serious side effects also can occur. If you have any of these side effects, call your doctor right away:

  • Severe rash, hives, or a rash that causes blisters and peeling
  • Yellowing of skin or eyes
  • Unusual bleeding or bruising
  • Seizure
  • Loss of consciousness
  • Swelling of face, lips, or tongue
  • Difficulty breathing
  • Decreased urine output or blood in the urine
  • Extreme sleepiness or confusion
  • Hallucinations
  • Tingling, numbness, or shakiness

Age matters, too. People older than 65 may have more side effects from Aciklovir because their kidneys do not get rid of the drug as quickly as younger people's do.

Why it's used

Aciklovir is used to treat viral infections. These include varicella-zoster (shingles), genital herpes, and chickenpox.

This drug doesn't cure herpes infections. The herpes virus can stay in your body for a long time and cause symptoms again later.

What Is Aciklovir (Zovirax) and How Does It Work?

Aciklovir is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, injectable, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of the brain). Herpes viral infections are very common. Genital herpes refers to a sexually transmitted disease (STD) that any sexually active person can contract and transmit.

Shingles and chicken pox are common skin conditions.Shingles and chicken pox are skin infections which are both caused by the herpes virus. They are not caused by the same virus that causes cold sores or genital herpes.

Many people who suffer from shingles or chicken pox (chickenpox) infection will experience symptoms such as a rash, often with pain, which is treatable with this drug.

Genital herpes is an STD caused by two types of viruses: herpes simplex type 1 and herpes simplex type 2. Most people with genital herpes do not know they have it. Still, symptoms often appear days to weeks after exposure. Symptoms of genital herpes generally include:

  • Flu-like symptoms such as fever, body aches, or swollen glands
  • Blisters, sores, or rash in the genital area with or without pain, itching, tingling
  • Blisters that pop open, causing painful sores.

Aciklovir may also help treat pain associated with an outbreak of genital herpes after the sores heal.

There is no cure for herpes, however, this prescription is a treatment that helps to decrease and ease symptoms of herpes infections.

Aciklovir is am antiviral drug that belongs to a class of medications called "antivirals," or "antiviral medications."

Your doctor may prescribe this drug as a treatment to relieve symptoms of your infection.

This medication is similar to the drug valAciklovir (Valtrex), which is another medication that may also be prescribed for herpes infections.

This drug may cause serious side effects or mild side effects. This includes side effects that may affect the liver. Side effects that affect the skin as well as allergic reactions have occurred.

Aciklovir is the generic equivalent of Zovirax.

Aciklovir

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Missed Dose of Aciklovir

You should take Aciklovir exactly as directed by your doctor. Also, do not stop taking Aciklovir on your own.

Skipping doses or stopping too soon may not completely treat your infection, or it could make the infection harder to treat.

If you miss a dose of Aciklovir, take the missed dose as soon as you remember.

If it's almost time for your next dose, skip the missed dose.

Do not double your dose to make up for a missed dose.

Nursing Mothers

Aciklovir concentrations have been documented in breast milk in 2 women following oral administration of ZOVIRAX (Aciklovir) and ranged from 0.6 to 4.1 times corresponding plasma levels. These concentrations would potentially expose the nursing infant to a dose of Aciklovir up to 0.3 mg/kg/day. ZOVIRAX (Aciklovir) should be administered to a nursing mother with caution and only when indicated.

Interactions

Drug-drug. Interferon: additive effect

Nephrotoxic drugs: increased risk of nephrotoxicity

Probenecid: increased Aciklovir blood level

Zidovudine: increased CNS effects, especially drowsiness

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, bilirubin, blood urea nitrogen: increased levels

Other uses for this medicine

Aciklovir is also sometimes used to treat eczema herpeticum (a skin infection caused by the herpes virus) to treat and prevent herpes infections of the skin, eyes, nose, and mouth in patients with human immunodeficiency virus (HIV), and to treat oral hairy leukoplakia (condition that causes hairy white or gray-colored patches on the tongue or inside of the cheek).

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.


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