• Active Ingredient: Acyclovir
  • 800 mg, 400 mg, 200 mg
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What is Acihexal?

The active ingredient of Acihexal brand is acyclovir. Acyclovir is an antiviral drug. It slows the growth and spread of the herpes virus in the body. Acyclovir will not cure herpes, but it can lessen the symptoms of the infection. The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared with VZV is due to its more efficient phosphorylation by the viral TK.

Used for

Acihexal is used to treat diseases such as: Cold Sores, Herpes Simplex, Herpes Simplex - Congenital, Herpes Simplex Encephalitis, Herpes Simplex, Mucocutaneous/Immunocompetent Host, Herpes Simplex, Mucocutaneous/Immunocompromised Host, Herpes Simplex, Suppression, Herpes Zoster, Infectious Mononucleosis, Mononucleosis, Ramsay Hunt Syndrome, Varicella-Zoster.

Side Effect

Possible side effects of Acihexal include: hallucinations (seeing, hearing, or feeling things that are not there); convulsions (seizures); Bleeding or oozing from puncture sites or mucous membranes (bowel, mouth, nose, or urinary bladder), continuing; large hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; decreased frequency of urination or amount of urine; buccal mucosa tablet; changes in vision.

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Q: Can Acihexal cause uncontrollable muscle twitching?

A: Acihexal (Zovirax) // is a medication used to treat viral infections. The most common side effects associated with the oral form of Acihexal are diarrhea, nausea, vomiting, headache, and feeling tired (malaise). Acihexal cream and ointment can cause skin irritation. A search of the prescribing information for Acihexal did not specifically list uncontrollable muscle twitching as a side effect. Tell your health-care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting or by calling 1-800-FDA-1088. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Mendoza, PharmD


Acihexal (Zovirax) is an antiviral drug prescribed to treat genital herpes, shingles, and chickenpox. Side effects drug interactions, dosing, storage, and pregnancy safety information should be reviewed prior to taking this medication.

Q: How long is Acihexal treatment?

A: How long Acihexal (Zovirax) treatment is intended for depends upon the indication for use. Acihexal is a prescription antiviral agent approved, by the U.S. Food and Drug Administration (FDA), for the acute treatment of herpes zoster (shingles), the treatment of initial episodes and the management of recurrent episodes of genital herpes and the treatment of chickenpox. Acihexal treatment is approved for all indications for adults and for the treatment of chickenpox in children 2 year of age and older. For the acute treatment of shingles, the length of Acihexal treatment is 7 to 10 days. The usual recommended adult dosage is 800 mg administered every 4 hours, 5 times daily. For the treatment of initial episodes of genital herpes, the length of Acihexal treatment is 10 days. The usual recommended adult dosage is 200 mg administered every 4 hours, 5 times daily. For the management of recurrent episodes of genital herpes, there were two methods of administration of Acihexal treatment evaluated in clinical trials. For intermittent therapy, the length of Acihexal treatment is 5 days. Treatment should be initiated at the earliest sign or symptom of recurrence, known as a prodrome. The usual adult dosage is 200 mg administered every 4 hours, 5 times daily. The other option is chronic suppressive therapy in which Acihexal treatment is used for up to 12 months and followed by re-evaluation by a health care provider to assess the need for continued treatment. The usual adult dosage is 400 mg twice daily. Alternative dosages may range from 200 mg 3 times daily to 200 mg 5 times daily, according to the prescribing information for Zovirax, the brand-name of Acihexal. For the treatment of chickenpox for adults and children, the recommended length of Acihexal treatment is 5 days. When treatment is required, it should be initiated at the earliest sign or symptom of chickenpox. The effectiveness of treatment initiated after 24 hours following the onset of symptoms is unknown. The usual dosage for adults and children weighing over 40 kg is 800 mg administered 4 times daily. The usual dosage for children 2 years of age and older is 20 mg/kg per dose administered 4 times daily.

History and Etymology for Acihexal

acycl(ic) + -o- + vir(us); from its containing less cyclic structure than its naturally occurring analogue guanosine

Acihexal Overdose

An overdose of Acihexal can cause kidney damage.

Symptoms of an overdose may include:

  • Agitation
  • Extreme sleepiness
  • Loss of consciousness
  • Seizures
  • Kidney failure (no urine production)

If you think that you or someone else has overdosed, call a poison control center at 1-800-222-1222.

If you or someone else has any severe symptoms after an overdose, call 9-1-1.

What Is Acihexal (Zovirax) and How Does It Work?

Acihexal is approved by the Food and Drug Administration as a prescription drug that is commonly used as a topical, injectable, and oral treatment for genital herpes and cold sores. Herpes refers to a group of viruses that cause a variety of herpes infections including genital herpes, shingles, chicken pox (also chickenpox), cold sores, and encephalitis (inflammation of the brain). Herpes viral infections are very common. Genital herpes refers to a sexually transmitted disease (STD) that any sexually active person can contract and transmit.

Shingles and chicken pox are common skin conditions.Shingles and chicken pox are skin infections which are both caused by the herpes virus. They are not caused by the same virus that causes cold sores or genital herpes.

Many people who suffer from shingles or chicken pox (chickenpox) infection will experience symptoms such as a rash, often with pain, which is treatable with this drug.

Genital herpes is an STD caused by two types of viruses: herpes simplex type 1 and herpes simplex type 2. Most people with genital herpes do not know they have it. Still, symptoms often appear days to weeks after exposure. Symptoms of genital herpes generally include:

  • Flu-like symptoms such as fever, body aches, or swollen glands
  • Blisters, sores, or rash in the genital area with or without pain, itching, tingling
  • Blisters that pop open, causing painful sores.

Acihexal may also help treat pain associated with an outbreak of genital herpes after the sores heal.

There is no cure for herpes, however, this prescription is a treatment that helps to decrease and ease symptoms of herpes infections.

Acihexal is am antiviral drug that belongs to a class of medications called "antivirals," or "antiviral medications."

Your doctor may prescribe this drug as a treatment to relieve symptoms of your infection.

This medication is similar to the drug valAcihexal (Valtrex), which is another medication that may also be prescribed for herpes infections.

This drug may cause serious side effects or mild side effects. This includes side effects that may affect the liver. Side effects that affect the skin as well as allergic reactions have occurred.

Acihexal is the generic equivalent of Zovirax.

Acihexal is just one of the most famously recommended antiviral drugs. It is used to decrease the development of the herpes pc virus permitting your physical body and the invulnerable system to fight off the infection. Acihexal is planned for patients identified with genital herpes, cold sores, roof shingles, and poultry pox. You need to take this medication for the entire length of time advised by your doctor, trying not to miss amounts and take Acihexal at normal periods. It's best to start the therapy as early as you notice the first signs of the infection, such as burning, tingling or blisters. Acihexal is not expected to affect the wellness of a coming infant, it can pass in to bust milk. Inform your physician regarding maternity or breastfeeding prior to starting to take Acihexal.

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