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Fungal infections sometimes occur within the body also. You are more at risk of developing an internal fungal infection if your immune system does not work properly. For example, if you are having chemotherapy, or if you are taking medicines for rheumatic disease, or if you have HIV/AIDS. Internal fungal infections can be serious.
You will have been prescribed Tracofung to treat a fungal infection, or to help prevent a fungal infection from developing. It works by killing yeast and fungi.
Tracofung is available on prescription, and it can also be bought at pharmacies, without a prescription, for the treatment of vaginal thrush.
Based on a case report in one patient receiving combination therapy with all-transretinoid acid (an acid form of vitamin A) and Tracofung, central nervous system (CNS) related undesirable effects have developed in the form of pseudotumor cerebri, which disappeared after discontinuation of Tracofung treatment. This combination may be used but the incidence of CNS related undesirable effects should be borne in mind.
Non-Steroidal Anti-Inflammatory Drugs
The Cmax and AUC of flurbiprofen were increased by 23% and 81%, respectively, when coadministered with Tracofung compared to administration of flurbiprofen alone. Similarly, the Cmax and AUC of the pharmacologically active isomer were increased by 15% and 82%, respectively, when Tracofung was coadministered with racemic ibuprofen (400 mg) compared to administration of racemic ibuprofen alone.
Although not specifically studied, Tracofung has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac). Frequent monitoring for adverse events and toxicity related to NSAIDs is recommended. Adjustment of dosage of NSAIDs may be needed.
The AUC and Cmax of glipizide (2.5 mg single dose) were significantly increased following the administration of Tracofung in 13 normal male volunteers. There was a mean ± SD increase in AUC of 49% ± 13% (range: 27 to 73%) and an increase in Cmax of 19% ± 23% (range: –11 to 79%). (See PRECAUTIONS.)
Tracofung inhibits the metabolism of losartan to its active metabolite (E-31 74) which is responsible for most of the angiotensin Il-receptor antagonism which occurs during treatment with losartan. Patients should have their blood pressure monitored continuously.
A placebo-controlled, randomized, multiple-dose study examined the potential interaction of Tracofung with cisapride. Two groups of 10 normal subjects were administered Tracofung 200 mg daily or placebo. Cisapride 20 mg four times daily was started after 7 days of Tracofung or placebo dosing. Following a single dose of Tracofung, there was a 101% increase in the cisapride AUC and a 91% increase in the cisapride Cmax. Following multiple doses of Tracofung, there was a 192% increase in the cisapride AUC and a 154% increase in the cisapride Cmax. Tracofung significantly increased the QTc interval in subjects receiving cisapride 20 mg four times daily for 5 days. (See CONTRAINDICATIONS and PRECAUTIONS.)
One fatal case of possible fentanyl-Tracofung interaction was reported. The author judged that the patient died from fentanyl intoxication. Furthermore, in a randomized crossover study with 12 healthy volunteers, it was shown that Tracofung delayed the elimination of fentanyl significantly. Elevated fentanyl concentration may lead to respiratory depression.
Drugs that increase the risk of side effects
Taking Tracofung with certain drugs raises your risk of side effects from those drugs. Examples of these drugs include:
- Diabetes drugs such as glyburide and glipizide. Increased side effects can include low blood sugar. This causes symptoms such as sweating and chills, shakiness, fast pulse, weakness, hunger, and dizziness.
- Warfarin. Increased side effects can include bruising, nosebleeds, and blood in your urine or stools.
- Phenytoin. Taking this drug with Tracofung can cause trouble with coordination, slurred speech, and confusion. Your doctor will measure blood levels of phenytoin while you’re taking Tracofung. It’s possible that your doctor will decrease your dose of phenytoin while you’re taking Tracofung.
- Cyclosporine, tacrolimus, and sirolimus. Increased side effects can include kidney damage. Your doctor will check your blood for signs of kidney damage while you’re taking Tracofung. If you show signs of kidney damage, your doctor may lower your doses of these drugs or stop them completely until your treatment with Tracofung is done.
- Theophylline. Taking this drug with Tracofung can cause muscle cramps, headache, low blood pressure, and seizures. Your doctor will measure blood levels of phenytoin while you’re taking Tracofung.
- Zidovudine. Increased side effects can include headache, tiredness, loss of appetite, nausea, and vomiting.
- Pain drugs, such as methadone and fentanyl. The levels of these drugs may be increased in your body when taken with Tracofung. Increased side effects include slower breathing, confusion, and drowsiness.
- Carbamazepine. Increased side effects include nausea, vomiting, unsteadiness, low blood cell counts, severe rash, heart failure, and liver failure.
- Certain calcium channel blockers, such as nifedipine, amlodipine, verapamil, and felodipine. Increased side effects include low blood pressure, dizziness, confusion, and headache.
- Certain statins, such as atorvastatin and simvastatin. Increased side effects include muscle pain and weakness and raised levels of creatinine in your blood.
- Antipsychotic drugs, such as chlorpromazine, haloperidol, and ziprasidone. Taking Tracofung with these medications raises your risk of a life-threatening irregular heart rhythm condition called torsades de pointes.
- Antidepressants, such as citalopram, escitalopram, and paroxetine. Taking Tracofung with these medications raises your risk of a life-threatening irregular heart rhythm condition called torsades de pointes.
- Heart rhythm drugs, such as amiodarone and dofetilide. Taking Tracofung with these medications raises your risk of a life-threatening irregular heart rhythm condition called torsades de pointes.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Tracofung oral tablet comes with several warnings