Michael Stewart, Reviewed by Sid Dajani | Last edited 23 Oct 2019 | Certified by The Information Standard
Telugren 1% solution is used to treat fungal infections in the ear.
Use 2-3 drops of solution, two or three times daily.
Continue to use the drops for at least 14 days after your symptoms have gone.
Telugren - Clinical Pharmacology
Telugren is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur . The primary action of Telugren is against dividing and growing organisms.
In vitro , Telugren exhibits fungistatic and fungic >Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis , and Candida species including Candida albicans . In general, the in vitro activity of Telugren corresponds to that of tolnaftate and griseofulvin against the mycelia of dermatophytes ( Trichophyton, Microsporum , and Epidermophyton ), and to that of the polyenes (amphotericin B and nystatin) against budding fungi ( Candida ). Using an in vivo (mouse) and an in vitro (mouse k >Candida albicans .
Strains of fungi having a natural resistance to Telugren are rare. Only a single isolate of Candida guilliermondi has been reported to have primary resistance to Telugren.
No single-step or multiple-step resistance to Telugren has developed during successive passages of Candida albicans and Trichophyton mentagrophytes . No appreciable change in sensitivity was detected after successive passages of isolates of C. albicans, C. krusei , or C. pseudotropicalis in liqu >C. albicans .
Slight, reversible resistance was noted in three isolates of C. albicans tested by one investigator. There is a single report that records the clinical emergence of a C. albicans strain with considerable resistance to flucytosine and miconazole, and with cross-resistance to Telugren; the strain remained sensitive to nystatin and amphotericin B.
In studies of the mechanism of action, the minimum fungicidal concentration of Telugren caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. Both these events began rapidly and extensively after addition of the drug.
Telugren appears to be well absorbed in humans following oral administration and is eliminated mainly as inactive metabolites. Following topical and vaginal administration, however, Telugren appears to be minimally absorbed.
Six hours after the application of radioactive Telugren 1% cream and 1% solution onto intact and acutely inflamed skin, the concentration of Telugren varied from 100 mcg/cm 3 , in the stratum corneum to 0.5 to 1 mcg/cm 3 in the stratum reticulare, and 0.1 mcg/cm 3 in the subcutis.
No measurable amount of radioactivity (≤0.001 mcg/mL) was found in the serum within 48 hours after application under occlusive dressing of 0.5 mL of the solution or 0.8 g of the cream.
Only 0.5% or less of the applied radioactivity was excreted in the urine.
Following intravaginal administration of 100 mg 14 C-Telugren vaginal tablets to nine adult females, an average peak serum level, corresponding to only 0.03 µg equivalents/mL of Telugren, was reached 1 to 2 days after application. After intravaginal administration of 5 g of 1% 14 C-Telugren vaginal cream containing 50 mg active drug, to five subjects (one with candidal colpitis), serum levels corresponding to approximately 0.01 µg equivalents/mL were reached between 8 and 24 hours after application.
How should this medicine be used?
Vaginal Telugren comes as a cream to be inserted into the vagina. It also may be applied to the skin around the outside of the vagina. The cream is inserted into the vagina once a day at bedtime for 3 or 7 days in a row, depending on the product instructions. The cream is used twice a day for up to 7 days around the outside of the vagina. Follow the directions on the package or your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Telugren exactly as directed. Do not use more or less of it or use it more often than directed on the package or prescribed by your doctor.
Vaginal Telugren is available without a prescription (over the counter). If this is the first time you have had vaginal itching and discomfort, talk to a doctor before using Telugren. If a doctor has told you before that you had a yeast infection and you have the same symptoms again, use the vaginal cream as directed on the package.
Do not have vaginal intercourse or use other vaginal products (such as tampons, douches, or spermicides) during your treatment.
You should begin to feel better during the first three days of treatment with Telugren. If your symptoms do not improve or get worse, call your doctor.
To apply the Telugren cream to the outside area around the vagina, use your finger to apply a small amount of cream to the affected area of skin.
Getting the most from your treatment
- Remember to wash your hands carefully after using Telugren, as this will help to prevent the infection from spreading to other parts of your body. Also, use a separate towel to other people until your infection clears up.
- Fungal infections often occur in warm, moist areas of the body. After washing or showering, make sure that all areas of your skin are dried well, particularly areas such as skin folds and between your toes.
- As a gu >
Otitis externa is a term used for inflammation in the ear when it is confined to the ear canal and does not go further than the eardrum. If you get things like water, shampoo or soap in your ear then it can cause itching. If you then scratch or poke your ear, this can damage the skin in the ear canal and cause inflammation. Sometimes the inflamed skin becomes infected by germs such as bacteria or fungi. Telugren solution is used to treat ear infections caused by fungi. It is available on prescription or you can buy it without a prescription at a pharmacy.
Im > Telugren is available as a 1% topical solution used for tinea versicolor or as a 10-mg troche used for oral thrush. The troches contain sugar and may promote caries if used in excess; otherwise they are nontoxic. They must be completely dissolved because any swallowed troche provides no benefit. The typical dosage for the treatment of oral candidiasis is four to five troches per day for 10 to 14 days. Miconazole is available as a 50-mg tablet for the treatment of oropharyngeal candidiasis. The tablet is taken once daily and should be placed into the buccal vestibule.
Ketoconazole is used for the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is only available in the oral form in 200-mg tablets. These tablets are taken once daily (with a maximum daily dose of 800-mg in severe fungal disease). 4 The absorption of ketoconazole is affected by gastric ac > absorption. Ketoconazole poorly penetrates the cerebrospinal fluid (CSF), eye, urine, and saliva because of its high affinity and degree of protein binding. Common side effects include decreased libido and gynecomastia, particularly at higher doses. 3 Additionally, adrenal suppression has been reported. 5 Other side effects include fatigue, rash, and nausea. Hepatitis is a rare complication of ketoconazole use.