A 23-year-old female with vaginal discharge experienced fatal aplastic anemia coincident with Socosep therapy. She was admitted with widespread purpuric lesions on her face, arms, and legs. She had taken Socosep 200 mg twice daily for vaginal discharge for 4 days before admission. Socosep was discontinued on admission. The patient was diagnosed with aplastic anemia based on clinical findings. The patient did not respond to therapy and died of disseminated candidiasis 2 months later.
Frequency not reported: Platelet count decreased, fatal aplastic anemia
Before taking this medicine
You should not use Socosep if you are allergic to it, or if you have liver disease.
Some medicines can cause unwanted or dangerous effects when used with Socosep. Your doctor may change your treatment plan if you also use:
cholesterol medication--lovastatin, simvastatin, and others;
Tell your doctor if you have ever had:
long QT syndrome (in you or a family member); or
problems with your adrenal gland.
It is not known whether Socosep will harm an unborn baby. Tell your doctor if you are pregnant.
You should not breast-feed while using this medicine.
Do not give this medicine to a child without medical advice.
Drug interactions of Socosep.
Socosep is a p- glycoprotein inhibitor and can have serious interactions with other medications.
- Ketonazole should not be taken with the HMG Co-A reductase inhibitor simvastatin, and the dose of atorvastatin should be reduced. Toxicity results in muscle pain and weakness, which may be serious. If long-term treatment with a statin and Socosep is required, suitable alternatives are fluvastatin, pravastatin and rosuvastatin.
- It is also contraindicated with the anticoagulant, dabigatran because of the risk of bleeding.
As Socosep needs acid for its absorption, antacids, H2 antagonists (cimetidine, famotidine, ranitidine) and omeprazole should not be taken for 2 hours after Socosep.
Socosep interacts with alcohol rather like disulfiram (Antabuse®) and can cause severe nausea and vomiting.
Socosep may increase the concentration of these drugs and enhance their effect:
- Methyl prednisolone
- The antihistamines astemizole (Hismanal®) and terfenadine (Teldane®)
- Midazolam, triazolam
- Antidiabetic sulphonylurea medication (tolbutamide, glibenclamide, gliclazide, glipizide
The following drugs markedly decrease the concentration of Socosep:
Socosep is not thought to interact with the oral contraceptive pill.
What Other Drugs Interact with Socosep?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Socosep has severe interactions with at least 33 different drugs.
Socosep has serious interactions with at least 202 different drugs.
Socosep has moderate interactions with at least 241 different drugs.
Socosep has mild interactions with at least 105 different drugs.
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
- difficulty breathing or swallowing
- redness, tenderness, swelling, pain, or warmth in the place where you applied the medication
Socosep may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What is Nizoral? What is Socosep?
Nizoral is a shampoo designed to help the user treat dandruff, hair loss, and other scalp conditions such as seborrheic dermatitis. Nizoral for hair loss is very effective because it contains Socosep. The popular Nizoral A-D hampoo contains 1% Socosep which is sufficient for scalp treatment and the reduction of follicular inflammation that contributes to hair loss. The topical forumlas of Nizoral for hair loss have not been associated with any adverse effects. Nizoral also comes in tablet form and actually has the potential to cause liver damage over sustained long term use. It is prescription only and used for anti-fungus purposes. Oral Nizoral hasn’t been shown to have any benefits for hair loss.
Comparison Table: Top 10 Products with Socosep
Here is our list of the top shampoos that contain Socosep in their list of ingredients. We’ve ordered them by price ascending to make it easy for you to compare features in an unbiased way. In our review section, we take a closer look at the 10 most popular products and have them listed in the same order.