Philazone cream

Philazone

  • Active Ingredient: Ketoconazole
  • 200 mg
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What is Philazone?

The active ingredient of Philazone brand is ketoconazole. Ketoconazole is an antifungal medication that fights infections caused by fungus. Molecular Formula: C26H28Cl2N4O4 Molecular Weight: 531.43 After a single topical application to the chest, back and arms of normal volunteers, systemic absorption of ketoconazole was not detected at the 5 ng/mL level in blood over a 72-hour period. Two dermal irritancy studies, a human sensitization test, a phototoxicity study and a photoallergy study conducted in 38 male and 62 female volunteers showed no contact sensitization of the delayed hypersensitivity type, no irritation, no phototoxicity and no photoallergenic potential due to Ketoconazole Cream, 2%.

Used for

Philazone is used to treat diseases such as: Blastomycosis, Chromomycosis, Chronic Mucocutaneous Candidiasis, Coccidioidomycosis, Dermatophytosis, Esophageal Candidiasis, Histoplasmosis, Onychomycosis, Fingernail, Onychomycosis, Toenail, Oral Thrush, Paracoccidioidomycosis, Tinea Corporis, Tinea Versicolor, Vaginal Yeast Infection.

Side Effect

Possible side effects of Philazone include: Change in number of sperm and their ability to move; nosebleeds; difficulty seeing at night; redness of the skin; joint pain, stiffness, or swelling.

How to Buy Philazone cream online?

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What are the side effects of Philazone?

Philazone generally is well tolerated. Commonly reported side effects of Philazone are:

Other important side effects of Philazone are rare; they include:

Liver dysfunction also has been reported. Signs of liver problems include unusual fatigue, loss of appetite, nausea and vomiting, yellowing of the skin (jaundice), dark urine, and pale stools. Development of these symptoms while taking Philazone should be reported to a physician.

What should I avoid while taking Philazone?

Do not drink alcohol. Dangerous side effects could occur.

Philazone could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Why is this medication prescribed?

Philazone cream is used to treat tinea corporis (ringworm; fungal skin infection that causes a red scaly rash on different parts of the body), tinea cruris (jock itch; fungal infection of the skin in the groin or buttocks), tinea pedis (athlete's foot; fungal infection of the skin on the feet and between the toes), tinea versicolor (fungal infection of the skin that causes brown or light colored spots on the chest, back, arms, legs, or neck), and yeast infections of the skin. Prescription Philazone shampoo is used to treat tinea versicolor. Over-the-counter Philazone shampoo is used to control flaking, scaling, and itching of the scalp caused by dandruff. Philazone is in a class of antifungal medications called imidazoles. It works by slowing the growth of fungi that cause infection.

What Is Philazone and How Does It Work?

Philazone is used to treat certain serious fungal infections in the body. Philazone belongs to the class of drugs called azole antifungals. It works by stopping the growth of the fungus.

Philazone should not be used to treat fungal infections on the skin and nails due to the risk of serious side effects and drug interactions. Talk to your doctor about other medications you can use to treat these types of infection.

Philazone is available under the following different brand names: Nizoral.

Dosages of Philazone:

Adult and Pediatric Dosage Forms and Strengths

Dosage Considerations – Should be Given as Follows:

Indicated for the treatment of the following systemic fungal infections in patients who have failed or who are intolerant to other therapies: blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis

  • Adult: 200-400 mg/day orally
  • Children under 2 years old: Safety and efficacy not established
  • Children 2 years old and older: 3.3-6.6 mg/kg/day orally

Renal impairment: No dosage modifications provided in manufacturer's labeling

  • No dosage modifications provided in manufacturer's labeling
  • If hepatotoxicity occurs during treatment (ALT levels above UNL or ALT 30% above baseline): Interrupt dosing and order a full set of liver tests

Used off-label to inhibit steroidogenesis in patients with Cushing syndrome

Used rarely and often toxic at doses required to reduce cortisol secretion

Recurrent Tinea Versicolor (Off-label)

Do not use tablets as first-line treatment; should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweigh the potential of hepatotoxicity

Avoid prescribing tablets to treat skin and nail fungal infections owing to risk of serious liver damage, adrenal gland problems, and harmful interactions with other medicines that outweigh its benefit in treating these conditions, which are not approved uses of the drug (these indications were removed from labeling by the FDA in 2013)

Do not use for fungal meningitis because of poor penetration into the cerebrospinal fluid (CSF)

How should I apply Philazone topical?

Use exactly as directed on the label, or as prescribed by your doctor.

Using more of this medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects.

Do not take by mouth. Topical medicine is for use only on the skin. Do not use on open wounds or irritated skin. Rinse with water if this medicine gets in your eyes, nose, or mouth.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Wash your hands before and after using this medicine.

Clean and dry the skin before applying Philazone cream, foam, or gel.

This medicine may be flammable. Do not use near high heat or open flame, or while smoking. Avoid heat or smoking until the medicine has completely dried on your skin.

Philazone shampoo is not for daily use. Allow at least 3 days to pass between uses.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.

Call your doctor if your symptoms do not begin to improve after 2 to 4 weeks of treatment, or if your condition gets worse.

Store Philazone topical at room temperature. Protect from light and do not refrigerate or freeze.

FDA warnings

Hormone problems warning: High doses of this drug can affect your body’s ability to secrete hormones in response to stress. Symptoms can include extreme thirst, weight loss, darkening of your skin, unusual tiredness, joint aches and pains, and loss of appetite. If you have these symptoms, call your doctor.

Philazone is a prescription drug. It’s available as an oral tablet, topical cream, topical foam, shampoo, and topical gel. The oral tablet is only available as a generic drug.

IMPORTANT WARNING:

Philazone should only be used to treat fungal infections when other medications are not available or cannot be tolerated.

Philazone may cause liver damage, sometimes serious enough to require liver transplantation or to cause death. Liver damage may occur in people who do not already have liver disease or any other conditions that increase the risk that they will develop liver damage. Tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had liver disease. Do not drink any alcoholic beverages during your treatment with Philazone because drinking alcoholic beverages may increase the risk that you will develop liver damage. If you experience any of the following symptoms, call your doctor immediately: extreme tiredness, loss of appetite, weight loss, nausea, vomiting, yellowing of the skin or eyes, dark yellow urine, pale stools, pain in the upper right part of the stomach, fever, or rash.

Philazone can cause QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). Do not take disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), pimozide (Orap), quinidine (Quinidex, Quinaglute), cisapride (Propulsid; no longer available in the US), methadone (Dolophine, Methadose), and ranolazine (Ranexa) while you are taking Philazone. If you experience any of the following symptoms, stop taking Philazone and call your doctor immediately: fast, pounding, or irregular heartbeat; fainting; dizziness; lightheadedness; or loss of consciousness.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to Philazone.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Philazone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of taking Philazone.

Interactions that can make your drugs less effective

  • When Philazone is less effective: When Philazone is used with certain drugs, it may not work as well to treat your condition. This is because the amount of Philazone in your body may be decreased. Examples of these drugs include:
    • Ranitidine, famotidine, cimetidine, pantoprazole, omeprazole, and rabeprazole. You should take Philazone with an acidic beverage, such as a non-diet soda, if you take these drugs together.
    • Aluminum hydroxide. You should take this drug 1 hour before or 2 hours after taking Philazone.
    • Antibiotics, such as isoniazid and rifabutin
    • Anticonvulsants, such as carbamazepine and phenytoin
    • Antivirals, such as efavirenz and nevirapine
    • Carbamazepine. Your doctor may monitor your carbamazepine levels.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.


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