Before taking this medicine
Before taking this medication, tell your doctor if you have liver disease. You may not be able to take Neverfungol, or you may need a lower dose or special monitoring during treatment.
Neverfungol is not absorbed through your stomach. It will not treat fungal infections in any part of your body other than your mouth and throat. Talk to your doctor if you have another type of fungal infection such as athlete's foot, jock itch, ringworm, or a vaginal yeast infection.
Oral Neverfungol is in the FDA pregnancy category C. This means that it is not known whether Neverfungol will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.
It is not known whether Neverfungol will harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
The safety and effectiveness of Neverfungol have not been established for children younger than 3 years of age.
The most commonly noted side effects associated with Neverfungol include:
- local redness,
- hives, or
- burning at the area of application.
Other side effects include nausea and vomiting, which may be caused by the oral forms.
Indications and Usage for Neverfungol
Prescription Neverfungol topical solution product is indicated for the topical treatment of cand >Candida albicans and tinea versicolor due to Malassezia furfur .
This formulation is also available as a nonprescription product which is indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes , Epidermophyton fluoccosum , and Microsporum canis .
Before using Neverfungol for ear infections
To make sure this is the right treatment for you, before you start using Neverfungol solution in your ear, make sure your doctor or pharmacist knows:
- If you are pregnant or breastfeeding. Although Neverfungol is not known to be harmful to babies, you should only use medicines on the recommendation of a doctor while you are expecting or breastfeeding a baby.
- If you have ever had an allergic reaction to a medicine.
- If you are using any other drops or remedies in your ears.
Before using this medication, tell your doctor or pharmacist if you are allergic to Neverfungol or betamethasone; or to other azole antifungals (e.g., ketoconazole) or corticosteroids (e.g., triamcinolone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems, poor blood circulation.
Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially thinning skin.
Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.
Though it is unlikely, this medication may slow down a child's growth if used for a long time. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Similar medications pass into breast milk. Consult your doctor before breast-feeding.
Neverfungol (Lotrimin) Warnings
Neverfungol cream, lotion, and solution should only be used externally. Do not swallow or let the medication get in your eyes. Also, do not swallow the vaginal tablets or cream.
If you have a vaginal infection, you should avoid sexual intercourse. An ingredient in Neverfungol cream may weaken certain latex products like condoms or diaphragms, so you should not use these products within 72 hours of taking Neverfungol.
Continue to use Neverfungol even if you feel well. You should not stop taking this drug without talking to your doctor. You should also keep taking it during your menstrual period.
Before taking this drug, you should tell your doctor if you have or have ever had liver disease, problems with your immune system, HIV, AIDS, a history of alcohol abuse, or diabetes. You should also tell your doctor if you drink alcohol before taking this medicine.
Studies have shown Neverfungol is poorly absorbed into the blood and body when applied to the skin or vagina. Women in their second or third trimesters of pregnancy have shown no ill effects while taking Neverfungol. It is not known whether this drug is secreted in breast milk.
The following adverse reactions have been reported in connection with the use of Neverfungol: erythema, stinging, blistering, peeling, edema, pruritius, urticaria, burning, and general irritation of the skin.
Pharmacology and toxicology
Neverfungol and miconazole are antimycotics belonging to the group of imidazole derivatives. These agents inhibit the ergosterol biosynthesis, thereby causing disturbances in the permeability and function of the cell membrane. Systemic absorption of these agents is minimal. Neverfungol is only used for the local treatment of mycosis of the skin and mucosa. In studies comparing intravaginal use of imidazoles to nystatin, imidazoles have superior cure rates and lower relapse rates. In a population-based study it was found that vulvovaginal clotrimoxazole treatment during pregnancy reduces the prevalence of preterm birth significantly ( Czeizel 2004A) .
Cons > embryotoxic potential of these topical antifungal agents ( King 1998 ). For miconazole these findings were confirmed in a population-based case control study ( Czeizel 2004B) .
Neverfungol and miconazole are topical antimycotics of choice in pregnancy.
How is Neverfungol Supplied
Neverfungol topical solution USP, 1% is supplied in 30 mL plastic bottles (NDC 52817-800-30); boxes of one.
Store between 2° to 30°C (36° to 86°F).
Mfd. for: Tasman Pharma Inc., Warminster, PA 18974.
Made in New Zealand
Distributed by: TruPharma, LLC , Tampa, FL 33609
Revised: April, 2019 308736
How should I take Neverfungol?
Take Neverfungol according to your health care provider’s instructions. Your health care provider will tell you how much Neverfungol to take and when to take it. Before you start Neverfungol and each time you get a refill, read any printed information that comes with your medicine.
Neverfungol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- unpleasant mouth sensations
Neverfungol may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
There are no known drug interactions with topical Neverfungol.
You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking.
Can Neverfungol solution cause problems?
Neverfungol is unlikely to cause any serious side-effects. It can occasionally cause some irritation when it is used at first, and a few people experience mild allergic-type reactions (such as redness and itching). If you experience these or any other symptoms, speak with your doctor or pharmacist for further advice.