Lamican cream

Lamican

  • Active Ingredient: Terbinafine
  • 250 mg
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What is Lamican?

The active ingredient of Lamican brand is terbinafine. Terbinafine is an antifungal medication that fights infections caused by fungus. Terbinafine hydrochloride USP is a white to off-white fine crystalline powder. It is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water. Each tablet contains: Active Ingredient: Terbinafine hydrochloride USP (equivalent to 250 mg of Terbinafine) Inactive Ingredients: Microcrystalline cellulose, sodium starch glycolate, colloidal silicon dioxide, hypromellose, and magnesium stearate.

Used for

Lamican is used to treat diseases such as: Cutaneous Candidiasis, Onychomycosis, Fingernail, Onychomycosis, Toenail, Tinea Capitis, Tinea Corporis, Tinea Cruris, Tinea Pedis.

Side Effect

Possible side effects of Lamican include: unexplained bleeding or bruising; shivering; sore throat; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; hair loss.

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Pill with imprint T is White, Round and has been identified as Lamican Hydrochloride 250 mg. It is supplied by Sandoz Pharmaceuticals Inc..

Lamican is used in the treatment of onychomycosis, toenail; cutaneous candidiasis; tinea capitis; onychomycosis, fingernail; tinea corporis and belongs to the drug class miscellaneous antifungals. There is no proven risk in humans during pregnancy. Lamican 250 mg is not a controlled substance under the Controlled Substances Act (CSA).

What is the most important information I should know about Lamican?

Some people taking Lamican have developed severe liver damage leading to liver transplant or death.

Call your doctor at once if you have symptoms of liver damage, such as nausea, upper stomach pain, vomiting, loss of appetite, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). These events can occur whether or not you have ever had liver problems before.

What is Lamican, and how does it work (mechanism of action)?

Lamican is an antifungal agent that is taken by mouth or applied to the skin. Lamican acts by interfering with the ability of fungi to make chemicals called sterols that are an important part of the membrane that surrounds fungal cells and holds them together. This weakens the cell membrane. Oral Lamican is more effective for treating fungal nail infections than griseofulvin (Fulvicin; Gris-Peg) and itraconazole (Sporanox), two other antifungal agents used for treating fungal nail infections. Topical Lamican was approved by the FDA in 1993. Lamican oral tablets were approved in 1996.

Side Effects

Diarrhea or stomach upset may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Changes in your sense of taste/smell or loss of taste/smell may occur. These side effects may improve after stopping Lamican, but can last for a long time or become permanent. Tell your doctor right away if you notice either of these side effects.

Tell your doctor right away if you have any serious side effects, including: vision changes, mental/mood changes (such as depression), unexplained bleeding/bruising, unusual tiredness, signs of kidney problems (such as change in the amount of urine).

Lamican may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn't stop, loss of appetite, severe stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Lamican (LamisilĀ®) is a synthetic antifungal agent of the allylamine class that inhibits squalene epoxidase, a complex membrane-bound enzyme system that is not part of the cytochrome P450 superfamily.

Pharmacology and toxicology

Lamican is used for both oral and topical therapy of nail mycoses and various tineal skin infections. There is little experience with its use during human pregnancy. In an ongoing study, the Canadian Motherisk program reports on 54 pregnancies exposed to Lamican; of these, 24 were exposed to systemic therapy and 23 to topical; 24 were exposed during the first trimester. Data collected thus far appear to suggest no increased risk for major malformations ( Sarkar 2003 ).

Lamican should not be used during pregnancy, because data on pregnancy outcome are lacking and nail mycosis is not a condition requiring urgent treatment. Inadvertent pregnancy exposure does not require termination of pregnancy. Detailed fetal ultrasonography can be considered after first-trimester exposure.

Lamican Hydrochlor > Imprint: T Strength: 250 mg Color: White Shape: Round Availability: Prescription only Drug Class: Miscellaneous antifungals Pregnancy Category: B - No proven risk in humans CSA Schedule: Not a controlled drug Labeler / Supplier: Sandoz Pharmaceuticals Inc. National Drug Code (NDC): 00781-5417

What Are Side Effects Associated with Using Lamican?

Common side effects of Lamican include:

Serious side effects of Lamican include:

  • Persistent nausea
  • Loss of appetite
  • Fatigue
  • Vomiting
  • Right upper abdominal pain
  • Yellowing skin and eyes (jaundice)
  • Dark urine
  • Pale stools
  • Smell disturbance

Postmarketing side effects of Lamican reported include:

  • Idiosyncratic and symptomatic hepatic injury; more rarely, cases of liver failure, some leading to death or liver transplant
  • Skin and subcutaneoustissue disorders (e.g., Stevens-Johnson Syndrome and toxic epidermal necrolysis), drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
  • Severe allergic reaction (anaphylaxis), skin swelling (angioedema)
  • Severe neutropenia, thrombocytopenia, agranulocytosis, pancytopenia, anemia
  • Psoriasiform eruptions or exacerbation of psoriasis, acute generalized exanthematous pustulosis, precipitation and exacerbation of cutaneous and systemic lupus erythematosus
  • Taste and smell disturbances
  • Malaise, fatigue, vomiting, joint pain, muscle pain, muscle wasting (rhabdomyolysis), reduced visual acuity, visual field defect, hair loss, serum sickness-like reaction, vasculitis, pancreatitis, influenza-like illness, pyrexia, increased bloodcreatine phosphokinase, photosensitivity reactions
  • Hearing impairment, spinning sensation (vertigo)
  • Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome

This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What should I avo >

Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medicine.

Avoid exposure to sunlight or tanning beds. Lamican can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What is the dosage for Lamican?

  • Tablets: The usual dose is 250 mg once daily for 6 weeks for treatment of the fingernails, and 12 weeks for treatment of toenails. Optimal results will not be seen for several months after treatment because it takes time for new healthy nails to grow. Lamican may be taken with or without food.
  • Cream, gel, spray, solution: Apply to affected area (s) once (jock itch, ringworm) or twice daily (athletes foot) for about for 1 week.

What is the metabolism of Lamican?

Lamican is absorbed well when taken orally, with or without food. It is bound to proteins such as albumin in the circulating blood and becomes concentrated in fat cells and within skin and nails . It is slowly eliminated in faeces and urine mostly after conversion by the liver into inactive compounds. It is a moderate CYP2D6 inhibitor. Doses may need to be reduced in the presence of kidney disease.

Skin concentrations may be up to 75-fold higher than those in the blood. It may persist in the skin for up to 8 weeks after the drug has been discontinued and in the nails for up to a year.

Some side effects can be serious. The following symptoms are uncommon; however, if you experience any of them, call your doctor immediately or get emergency medical treatment:

  • nausea
  • loss of appetite
  • extreme tiredness
  • vomiting
  • pain in the right upper part of the stomach
  • dark urine
  • pale stools
  • yellowing of the skin or eyes
  • severe skin rash that keeps getting worse
  • fever, sore throat, and other signs of infection
  • swelling of the face, throat, tongue, lips, and eyes
  • difficulty swallowing or breathing
  • hoarseness
  • swollen lymph glands
  • peeling, blistering, or shedding skin
  • hives
  • itching
  • red or scaly rash that may be sensitive to sunlight
  • loss of skin color
  • mouth sores
  • sore throat, fever, chills, and other signs of infection
  • chest pain
  • unexplained bleeding or bruising
  • blood in urine
  • fast or irregular heartbeat

You should know that Lamican may cause a loss or a change in the way you taste or smell. Loss of taste can cause decreased appetite, weight loss, and anxious or depressed feelings. These changes may improve shortly after you stop treatment with Lamican it may last a long time, or it may be permanent. If you notice a loss or a difference in the way you taste or smell, call your doctor.

Lamican may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).


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