Kezole tablets

Kezole

  • Active Ingredient: Ketoconazole
  • 200 mg
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What is Kezole?

The active ingredient of Kezole brand is ketoconazole. Ketoconazole is an antifungal medication that fights infections caused by fungus. Molecular Formula: C26H28Cl2N4O4 Molecular Weight: 531.43 After a single topical application to the chest, back and arms of normal volunteers, systemic absorption of ketoconazole was not detected at the 5 ng/mL level in blood over a 72-hour period. Two dermal irritancy studies, a human sensitization test, a phototoxicity study and a photoallergy study conducted in 38 male and 62 female volunteers showed no contact sensitization of the delayed hypersensitivity type, no irritation, no phototoxicity and no photoallergenic potential due to Ketoconazole Cream, 2%.

Used for

Kezole is used to treat diseases such as: Blastomycosis, Chromomycosis, Chronic Mucocutaneous Candidiasis, Coccidioidomycosis, Dermatophytosis, Esophageal Candidiasis, Histoplasmosis, Onychomycosis, Fingernail, Onychomycosis, Toenail, Oral Thrush, Paracoccidioidomycosis, Tinea Corporis, Tinea Versicolor, Vaginal Yeast Infection.

Side Effect

Possible side effects of Kezole include: swollen glands; Change in number of sperm and their ability to move; nosebleeds; chest pain; loss of appetite; swelling of the breasts or breast soreness for both female and male.

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Why it's used

Kezole is used to treat fungal and yeast infections on your skin, hair, nails, and in your blood. This drug is only given when other treatments haven’t worked or caused too many side effects.

Kezole for Hair Loss: The Link Between the Two

After identifying its success in treating dandruff, scientists began looking into its ability to manage seborrheic dermatitis. They found that using a shampoo containing a 2% concentration for two to four weeks resulted in an 88% reduction in the condition. When the study’s participants continued to use it following the end of the trial period, their hair loss didn’t return.

It’s therefore fair to assume that Kezole is useful for treating seborrheic dermatitis. As this is a condition that involves temporary hair loss, using Kezole ability to break down the cell membrane of fungi will restore any temporary hair loss you encounter.

Identification

Kezole is available in tablet form to treat fungal infections of the urinary tract, skin or mouth and is also available as a shampoo to treat fungal infections and other conditions of the scalp. One percent Kezole shampoo is available over-the-counter, while the stronger 2 percent shampoo requires a prescription. The American Hair Loss Association reports that the 1 percent version may not be as effective as the 2 percent prescription-strength shampoo 2.

Signs of allergic reaction

Allergic reactions to Kezole shampoo are extremely rare, but should be taken seriously. Seek immediate medical attention if you have signs of an allergic reaction like:

  • severe itching
  • swelling of the face, tongue, or throat
  • difficulty breathing
  • rash
  • dizziness

What is Kezole?

Kezole belongs to a group of medications called the ‘azole antifungals.’ It’s available as an oral and topical medication, with the aim of treating certain fungal conditions. Its role is to stop the growth of fungus, but you must remain wary of applying the wrong product to your skin, as it can irritate.

Shampoos that contain Kezole stop fungus from spreading by killing their cell membranes. In other words, they break down the cell walls. When the fungi no longer have active cell walls, they find it difficult to spread. It achieves this by stopping them from producing a substance called ‘ergosterol,’ which they need to prevent holes from appearing in the cell membrane.

When holes appear in the cell membrane, substances that fungi would otherwise love to keep out start to filter in. Interestingly, scientists have found the ergosterol serves similar purposes to cholesterol.

What other drugs will affect Kezole topical?

Medicine used on the skin is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Dermatitis, dandruff, and hair loss

As we’ve already discussed, Kezole works its way into the cell membranes of fungi and breaks them apart by stopping them from producing their form of testosterone. When the fungus is present on your scalp, it induces inflammation, which reduces your scalp’s ability to grow hair.

This is especially troublesome if you develop ‘folliculitis.’ As a condition that’s difficult to distinguish from seborrheic dermatitis, folliculitis can lead to permanent hair loss when you don’t treat it quickly enough. As such, disrupting the membranes of the fungi causing your dermatitis or dandruff reduces inflammation, with the following benefits:

  • Your scalp’s follicles become healthier, allowing for better hair growth
  • You slow down the inflammatory processes, which means you reduce the risk of permanent damage to the hair follicles

Hair loss

While Kezole is most frequently used for its antifungal properties to treat infections or conditions like seborrheic dermatitis, there is anecdotal ev >One small pilot study consisting of 15 people with alopecia, for example, found that Kezole may be able to improve hair regrowth.

Different types of Kezole shampoos are available OTC and by prescription from a healthcare provider.

OTC Kezole shampoos contain 1 percent or less of Kezole. The most commonly known OTC brand is Nizoral, which is available in most supermarkets and online for purchase.

You can obtain shampoos that contain 2 percent or more of Kezole with a prescription from your doctor. Brands available by prescription include:

Kezole can have negative side effects that you should be aware of before using it. One of the most common side effects is skin irritation, which can take the form of pimple-like bumps where it’s used. In some individuals, it may also cause either oiliness or dryness of the hair or scalp, abnormal hair texture, or discoloration. It can cause permed hair to lose its curl as well.

In rare cases, Kezole shampoo can result in hair loss, so talk to your doctor right away if you notice this side effect.

What other information should I know?

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Kezole.

Do not let anyone else take your medication. Ask your pharmacist if you have any questions about refilling your prescription. If you still have symptoms of infection after you finish the Kezole, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • rash
  • hives
  • itching
  • swelling of the eyes, face, lips, tongue, hands, feet, ankles, or lower legs
  • hoarseness
  • difficulty breathing or swallowing
  • tiredness or weakness

Kezole may cause a decrease in the number of sperm (male reproductive cells) produced, especially if it is taken at high doses. Talk to your doctor about the risks of taking this medication if you are a man and would like to have children.

Kezole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I avoid while using Kezole topical?

Do not get this medicine in your eyes. If contact does occur, rinse with water.

Avoid covering treated skin areas with tight-fitting, synthetic clothing (such as nylon or polyester) that doesn't allow air to circulate to your skin. If you are treating your feet, wear clean cotton socks and sandals or shoes that allow for air circulation. Keep your feet as dry as possible.

You may need to avoid sunlight if you are treating pityriasis. Follow your doctor's instructions.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime.

Avoid using other medications on the areas you treat with Kezole topical unless your doctor tells you to.


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