Ketoisdin tablets

Ketoisdin

  • Active Ingredient: Ketoconazole
  • 200 mg
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What is Ketoisdin?

The active ingredient of Ketoisdin brand is ketoconazole. Ketoconazole is an antifungal medication that fights infections caused by fungus. Molecular Formula: C26H28Cl2N4O4 Molecular Weight: 531.43 After a single topical application to the chest, back and arms of normal volunteers, systemic absorption of ketoconazole was not detected at the 5 ng/mL level in blood over a 72-hour period. Two dermal irritancy studies, a human sensitization test, a phototoxicity study and a photoallergy study conducted in 38 male and 62 female volunteers showed no contact sensitization of the delayed hypersensitivity type, no irritation, no phototoxicity and no photoallergenic potential due to Ketoconazole Cream, 2%.

Used for

Ketoisdin is used to treat diseases such as: Blastomycosis, Chromomycosis, Chronic Mucocutaneous Candidiasis, Coccidioidomycosis, Dermatophytosis, Esophageal Candidiasis, Histoplasmosis, Onychomycosis, Fingernail, Onychomycosis, Toenail, Oral Thrush, Paracoccidioidomycosis, Tinea Corporis, Tinea Versicolor, Vaginal Yeast Infection.

Side Effect

Possible side effects of Ketoisdin include: chest pain; change in color vision; loss in sexual ability, desire, drive, or performance; swelling of the eyelids, face, lips, hands, or feet; sleepiness or unusual drowsiness; unusual tiredness or weakness.

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Warnings

  • Tablets should be used only when other effective antifungal therapy is not available or tolerated and the potential benefits are considered to outweigh the potential risks
  • Liver damage (hepatotoxicity) has occurred with oral use, including some fatalities or requiring liver transplantation; reported with oral administration of drug; some patients had no obvious risk factors for liver disease
  • May cause QT prolongation; co-administration with dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, and ranolazine is contraindicated; Ketoisdin can cause elevated plasma concentrations of these drugs (by CYP3A4 inhibition) and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes
  • This medication contains Ketoisdin. Do not take Nizoral if you are allergic to Ketoisdin or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

How should I take Ketoisdin (Nizoral)?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Ketoisdin.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may need to use this medicine for up to 6 months.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Ketoisdin will not treat a viral infection such as the flu or a common cold.

While using Ketoisdin, you may need frequent blood tests to check your liver function.

Store at room temperature away from moisture, heat, and light.

Do not share this medicine with another person, even if they have the same symptoms you have.

Interactions

Drug-drug. Antacids, anticholinergics, histamine2-receptor antagonists: decreased Ketoisdin absorption

Cyclosporine: increased cyclosporine blood level

Isoniazid, rifampin: increased Ketoisdin metabolism

Theophylline: decreased theophylline blood level

Topical corticosteroids: increased corticosteroid absorption

Triazolam (oral): increased triazolam effects

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase: increased levels

Hemoglobin, platelets, white blood cells: decreased levels

Drug-herbs. Yew: inhibited Ketoisdin metabolism

In case of emergency/overdose

If someone swallows Ketoisdin cream or shampoo, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Before taking this medicine

You should not use Ketoisdin if you are allergic to it, or if you have liver disease.

Some medicines can cause unwanted or dangerous effects when used with Ketoisdin. Your doctor may change your treatment plan if you also use:

cholesterol medication--lovastatin, simvastatin, and others;

Tell your doctor if you have ever had:

long QT syndrome (in you or a family member); or

problems with your adrenal gland.

It is not known whether Ketoisdin will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using this medicine.

Do not give this medicine to a child without medical advice.

Signs of allergic reaction

Allergic reactions to Ketoisdin shampoo are extremely rare, but should be taken seriously. Seek immediate medical attention if you have signs of an allergic reaction like:

  • severe itching
  • swelling of the face, tongue, or throat
  • difficulty breathing
  • rash
  • dizziness

What Other Drugs Interact with Ketoisdin?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Ketoisdin has severe interactions with at least 33 different drugs.

Ketoisdin has serious interactions with at least 202 different drugs.

Ketoisdin has moderate interactions with at least 241 different drugs.

Ketoisdin has mild interactions with at least 105 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Ketoisdin, an anti-fungal medication, can also be effective in stimulating new hair growth if you suffer from androgenetic alopecia 1. Androgenetic alopecia, also called male and female pattern baldness, is a frequent cause of hair loss in both men and women, although it is more common in men, according to the Genetics Home Reference website 1.

Hypersensitivity

A 72-year-old female with a Candida albicans infection experienced a severe reaction of refractory anaphylactic shock coincident with Ketoisdin therapy. She was initially given oral Ketoisdin 200 mg twice daily. She developed hypotension over the first 2 days of treatment (BP 136/82 mmHg at baseline; 90/50 mmHg on day 2). Severe hypotension (BP 90/49 mmHg) unresponsive to fluid therapy or high-dose dopamine developed on day 4 of treatment. When laboratory tests revealed a high level of plasma tryptase, anaphylactic redistribution shock was diagnosed. Her vital signs became more stable after therapy with hydrocortisone and epinephrine infusion.

Frequency not reported: Anaphylactoid reaction, hypersensitivity reactions (including urticaria), anaphylaxis (sometimes after first dose), cross-sensitivity between imidazoles, drug hypersensitivity (presenting as rash, erythema, pruritus)

Postmarketing reports: Allergic conditions including anaphylactic shock, anaphylactic reaction, angioneurotic edema

How should I take Ketoisdin?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Ketoisdin.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may need to use this medicine for up to 6 months.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Ketoisdin will not treat a viral infection such as the flu or a common cold.

While using Ketoisdin, you may need frequent blood tests to check your liver function.

Store at room temperature away from moisture, heat, and light.

Do not share this medicine with another person, even if they have the same symptoms you have.

More common side effects

Some of the more common side effects of Ketoisdin include:

  • nausea
  • headache
  • diarrhea
  • stomach pain
  • abnormal liver function test results

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Drugs you should not use with Ketoisdin

Certain drugs should not be taken with Ketoisdin. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Antiarrhythmic drugs, such as dofetilide, quinidine, and dronedarone. Taking these drugs with Ketoisdin may cause a heart problem called QT prolongation. This is a change in the electrical activity in the heart. It can cause irregular heartbeats and be life-threatening.
  • Methadone. Taking these drugs together may cause a heart problem called QT prolongation. This is a change in the electrical activity in the heart. It can cause irregular heartbeats and be life-threatening.
  • Ranolazine. Taking these drugs together may cause a heart problem called QT prolongation. This is a change in the electrical activity in the heart. It can cause irregular heartbeats and be life-threatening.
  • Simvastatin or lovastatin. Taking Ketoisdin with these drugs may cause muscle problems.
  • Triazolam, midazolam, or alprazolam. Taking these drugs together may make you feel very drowsy for a long period of time.
  • Eplerenone. Taking these drugs together may cause low blood pressure and low potassium levels.

Other uses for this medicine

Ketoisdin cream and prescription shampoo are also sometimes used to treat dandruff and seborrheic dermatitis (condition that causes flaking of the skin). Ketoisdin cream is sometimes used to treat tinea manuum (fungal infection of the skin on the hands). Ketoisdin cream is also sometimes used with other medications to treat skin conditions that are often worsened by fungal infection such as diaper rash, eczema (skin irritation caused by allergies), impetigo (blisters caused by a bacterial infection), and psoriasis (a lifelong skin condition). Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Drug interactions of Ketoisdin.

Ketoisdin is a p- glycoprotein inhibitor and can have serious interactions with other medications.

  • Ketonazole should not be taken with the HMG Co-A reductase inhibitor simvastatin, and the dose of atorvastatin should be reduced. Toxicity results in muscle pain and weakness, which may be serious. If long-term treatment with a statin and Ketoisdin is required, suitable alternatives are fluvastatin, pravastatin and rosuvastatin.
  • It is also contraindicated with the anticoagulant, dabigatran because of the risk of bleeding.

As Ketoisdin needs acid for its absorption, antacids, H2 antagonists (cimetidine, famotidine, ranitidine) and omeprazole should not be taken for 2 hours after Ketoisdin.

Ketoisdin interacts with alcohol rather like disulfiram (Antabuse®) and can cause severe nausea and vomiting.

Ketoisdin may increase the concentration of these drugs and enhance their effect:

  • Warfarin
  • Methyl prednisolone
  • Cisapride
  • The antihistamines astemizole (Hismanal®) and terfenadine (Teldane®)
  • ciclosporin
  • Midazolam, triazolam
  • Busulfan
  • Antidiabetic sulphonylurea medication (tolbutamide, glibenclamide, gliclazide, glipizide

The following drugs markedly decrease the concentration of Ketoisdin:

Ketoisdin is not thought to interact with the oral contraceptive pill.

Ketoisdin for Hair Loss: A Proven Method

A shampoo with Ketoisdin must be a part of your regime. Without it, any other treatment you use will not be able to work optimally. Even when it comes to the tried and true Rogaine and Propecia, they too will work better on a scalp environment that is actively being treated with Ketoisdin. So what is its application in regards to hair loss? Simply put, it is the only proven shampoo ingredient on the market that can help prevent or slow hair loss. Multiple studies have proven the effectiveness of Ketoisdin as at the very least, a partial cure to hair loss.


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