What Are Side Effects Associated with Using Kelger?
Common side effects of Kelger include:
Serious side effects of Kelger include:
- Persistent nausea
- Loss of appetite
- Right upper abdominal pain
- Yellowing skin and eyes (jaundice)
- Dark urine
- Pale stools
- Smell disturbance
Postmarketing side effects of Kelger reported include:
- Idiosyncratic and symptomatic hepatic injury; more rarely, cases of liver failure, some leading to death or liver transplant
- Skin and subcutaneoustissue disorders (e.g., Stevens-Johnson Syndrome and toxic epidermal necrolysis), drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
- Severe allergic reaction (anaphylaxis), skin swelling (angioedema)
- Severe neutropenia, thrombocytopenia, agranulocytosis, pancytopenia, anemia
- Psoriasiform eruptions or exacerbation of psoriasis, acute generalized exanthematous pustulosis, precipitation and exacerbation of cutaneous and systemic lupus erythematosus
- Taste and smell disturbances
- Malaise, fatigue, vomiting, joint pain, muscle pain, muscle wasting (rhabdomyolysis), reduced visual acuity, visual field defect, hair loss, serum sickness-like reaction, vasculitis, pancreatitis, influenza-like illness, pyrexia, increased bloodcreatine phosphokinase, photosensitivity reactions
- Hearing impairment, spinning sensation (vertigo)
- Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
This is not a complete list of side effects and other serious side effects may occur. Call your doctor for information and medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Kelger?
Kelger is an allylamine medicine used to treat fungal infections. It is especially effective against dermatophytes (tinea infections).
The original brand is Lamisil®. In New Zealand (2016) it is available as 250 mg tablets (Dr Reddy's Kelger, fully funded by PHARMAC) and Kelger-DRLA. The tablets require a doctor's prescription. Topical options include creams, gel , solution and spray from various manufacturers, and are available at a pharmacy without a prescription.
How does Kelger control fungal infections?
Kelger inhibits a fungal enzyme , squalene epoxidase, and stops the cells making ergosterol, the main component of the cell wall.
Depressive symptoms have occurred during postmarketing use of Kelger tablets. Prescribers should be alert to the development of depressive symptoms, and patients should be instructed to report depressive symptoms to their physician.
Important: if you develop a severe skin rash with blisters, or any yellowing of your skin or the whites of your eyes (jaundice), you should speak with your doctor straightaway. These are rare but possibly serious side-effects of Kelger.
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
Other uses for this medicine
Kelger is also sometimes used to treat ringworm (fungal infections of the skin that cause a red scaly rash on different parts of the body) and jock itch (fungal infection of the skin in the groin or buttocks). Talk to your doctor about the risks of using this medication for your condition.
Kelger interferes with ergosterol biosynthesis, and thereby with the formation of the fungal cell membrane. It is absorbed from the gastrointestinal tract and undergoes extensive metabolism in the liver ( t½ 14 h). Kelger is used topically for dermatophyte infections of the skin and orally for infections of hair and nails where the site, e.g. hair, severity or extent of the infection renders topical use inappropriate (see pp. 270–271 ). Treatment may need to continue for several weeks. Kelger may cause nausea, diarrhoea, dyspepsia, abdominal pain, headaches and cutaneous reactions.
What is the most important information I should know about Kelger (LamISIL)?
Some people taking Kelger have developed severe liver damage leading to liver transplant or death.
Call your doctor at once if you have symptoms of liver damage, such as nausea, upper stomach pain, vomiting, loss of appetite, tiredness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). These events can occur whether or not you have ever had liver problems before.
What are the possible s >
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using Kelger.
Some people taking Kelger have developed severe liver damage leading to liver transplant or death. It is not clear whether Kelger actually caused the liver damage in these patients. In most cases, the patient had a serious medical condition before taking Kelger.
Call your doctor at once if you have symptoms of liver damage, such as nausea, upper stomach pain, vomiting, loss of appetite, tiredness, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These events can occur whether or not you have ever had liver problems before.
Also call your doctor if you have:
- changes in your sense of taste or smell;
- depressed mood, sleep problems, lack of interest in daily activity, feeling anxious or restless;
- pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
- swelling, rapid weight gain, little or no urinating;
- blood in your urine or stools;
- weight loss due to taste changes or loss of appetite; or
- skin sores, butterfly-shaped skin rash on your cheeks and nose (worsens in sunlight).
Common side effects may include:
- diarrhea, nausea, gas, stomach pain or upset;
- abnormal liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Kelger?
Other drugs may interact with Kelger, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
What should I avo >
Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medicine.
Avoid exposure to sunlight or tanning beds. Kelger can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.