How to store Hongogen
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
How to use Hongogen solution as ear drops
- Wash your hands. Clean your ear gently with warm water and then pat it dry.
- Lie down, or tilt your head a little, so that the affected ear is facing upwards.
- Gently pull your earlobe downwards to straighten the ear canal.
- Hold the dropper from the bottle near to your ear and apply enough pressure to release two or three drops of solution into your ear.
- Keep your ear facing upwards for a few minutes to allow the solution to come into contact with the affected area.
- Repeat the process in your other ear if both ears are affected.
- Replace the bottle dropper.
Is Hongogen safe to take if I'm pregnant or breastfeeding?
Hongogen is very poorly absorbed into the blood and the body after application to the skin or the vagina. Studies in women in their second or third trimesters of pregnancy have demonstrated no ill effects. No data is available in pregnant women during their first trimester. Rats given large amounts of Hongogen via the vagina have demonstrated no ill effects. The oral troche has not been adequately evaluated in pregnant women.
It is not known if Hongogen is secreted in breast milk.
Michael Stewart, Reviewed by Sid Dajani | Last edited 23 Oct 2019 | Certified by The Information Standard
Hongogen 1% solution is used to treat fungal infections in the ear.
Use 2-3 drops of solution, two or three times daily.
Continue to use the drops for at least 14 days after your symptoms have gone.
Take all of the Hongogen that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.
Betamethasone-Hongogen Topical Interactions
Avoid getting this medicine in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water. Do not use betamethasone and Hongogen topical on sunburned, windburned, dry, chapped, irritated, or broken skin.
Avoid wearing tight-fitting clothing that doesn't allow air circulation. Until the infection is healed, wear clothing that is made of natural fibers such as cotton.
It is not likely that other drugs you take orally or inject will have an effect on topically applied betamethasone and Hongogen. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Azole Drugs Used Topically
The topical azoles include miconazole, Hongogen , butoconazole, terconazole, tioconazole, sertaconazole, sulconazole, oxiconazole, econazole, efinaconazole, luliconazole, and ketoconazole. Miconazole and Hongogen are of special interest in oral candidiasis as discussed next.
Hongogen is an imidazole antifungal drug used for various mucosal and cutaneous infections. The antifungal spectrum and mechanism of action are similar to the other imidazole derivatives. For the treatment of oral candidiasis, Hongogen is available as a 10-mg troche (see Table 34-2 ). Slow dissolution in the mouth results in the binding of Hongogen to the oral mucosa, from which it is gradually released to maintain at least fungistatic concentrations for several hours. The swallowed drug is variably but poorly absorbed. It is metabolized in the liver and eliminated in the feces along with the unabsorbed drug.
One troche dissolved in the mouth five times a day for 2 weeks is the standard regimen for oropharyngeal candidiasis. Patient compliance is believed to be enhanced by the more pleasant taste of Hongogen compared with nystatin. Hongogen also appears to be highly effective and is the drug of choice for the treatment of oral candidiasis in patients with AIDS. For cutaneous candidiasis and dermatophytoses, a 1% cream or lotion is equivalent to topical miconazole.
Adverse oral effects associated with topical Hongogen, though unlikely, may include oral burning, altered taste, and xerostomia. Occasionally, minor gastrointestinal upset may follow oral ingestion of the drug.
Miconazole (see Fig. 34-3 ) is an imidazole that is useful against cutaneous candidiasis and vulvovaginitis caused by C. albicans; these conditions usually respond rapidly and reliably to a 2% miconazole nitrate cream. A buccal tablet is available for treatment of oral candidiasis. The tablet is pressed on the gingiva in the canine fossa above tooth #8 or #9 (see Table 34-2 ). It adheres there and releases the drug over a period of about 6 hours. Adverse oral effects are similar to those of Hongogen, with the additional possibility of gingival irritation and pain at the application site. Other topical uses of miconazole are for the treatment of cutaneous infections caused by Epidermophyton, Microsporum, and Trichophyton.
Terconazole, a member of the triazole antifungals, is supplied in a vaginal suppository for vaginal candidiasis. Butoconazole and tioconazole are imidazoles that are also used topically for vulvovaginitis. Oxiconazole, econazole, sertaconazole, and sulconazole are imidazoles used topically for infections caused by dermatophytes ( Table 34-3 ).
TABLE 34-3 . Topical Use of Antifungal Drugs
How should I take Hongogen?
Take Hongogen exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
The troches should be allowed to dissolve slowly in your mouth. Suck on one troche at a time until it is completely dissolved, usually 30 minutes.
Do not chew or swallow the troches whole.
The troches are usually used five times a day. Follow your doctor's instructions.
Store Hongogen at room temperature away from moisture and heat.
What is Hongogen?
Hongogen is an antifungal that has different uses in over-the-counter (OTC) medicines. Depending on the dose and form, Hongogen can be used to treat symptoms associated with skin fungus infections such as athlete’s foot, jock itch, and ringworm. Hongogen can also be used to treat vaginal yeast infections.
Locally effective antimycotics include nystatin and Hongogen . For all practical purposes, they are not absorbed and are not available to the infant enterally. Extensive experience with their therapeutic use in infancy argues against any toxic potential. The same applies to miconazole, which is also, for all practical purposes, not absorbed.
Bifonazole, croconazole, econazole, fenticonazole, isoconazole, ketoconazole, omoconazole, oxiconazole, sertaconazole, and tioconazole are related to Hongogen structurally and in their action, but they have been studied less. There has been no experience with amorolfin, ciclopiroxolamin, naftifin, terbinafine, tolcyclate, and tolnaftate, or with the vaginally administered chlorphenesin.
Local antimycotics of choice during breastfeeding are nystatin and Hongogen. Miconazole is also acceptable. These three drugs are preferable to the other abovementioned locally effective antimycotics. If one of the other medications is urgently indicated, breastfeeding can continue with no limitation if its use is only temporary or if only small areas are being treated.
How is Hongogen Supplied
Hongogen topical solution USP, 1% is supplied in 30 mL plastic bottles (NDC 52817-800-30); boxes of one.
Store between 2° to 30°C (36° to 86°F).
Mfd. for: Tasman Pharma Inc., Warminster, PA 18974.
Made in New Zealand
Distributed by: TruPharma, LLC , Tampa, FL 33609
Revised: April, 2019 308736
Otitis externa is a term used for inflammation in the ear when it is confined to the ear canal and does not go further than the eardrum. If you get things like water, shampoo or soap in your ear then it can cause itching. If you then scratch or poke your ear, this can damage the skin in the ear canal and cause inflammation. Sometimes the inflamed skin becomes infected by germs such as bacteria or fungi. Hongogen solution is used to treat ear infections caused by fungi. It is available on prescription or you can buy it without a prescription at a pharmacy.
Before using this medication, tell your doctor or pharmacist if you are allergic to Hongogen or betamethasone; or to other azole antifungals (e.g., ketoconazole) or corticosteroids (e.g., triamcinolone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems, poor blood circulation.
Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially thinning skin.
Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.
Though it is unlikely, this medication may slow down a child's growth if used for a long time. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Similar medications pass into breast milk. Consult your doctor before breast-feeding.
What happens if I overdose?
Seek emergency medical attention.
Symptoms of a Hongogen overdose are unknown.
Pharyngeal and upper airway irritation is a potential complication. Care should be taken to allow all of the solution to drain from the nasal cavity by keeping the head tilted ventrally over the edge of the table for a short period of time after the procedure. In addition, gauze sponges should be packed into the pharynx during the procedure to catch any of the solution that may leak from the nasopharynx.
In dogs with cribriform invasion, Hongogen may cause CNS irritation, which may result in seizures.
Hongogen S >
The most common side effects of Hongogen are redness, blistering, peeling, stinging, swelling, itching, hives, or burning at the site of application. Hongogen may also cause stomach pain, nausea, vomiting, fever, or foul-smelling discharge (if using the vaginal product). If any of these symptoms become severe, you should contact your doctor.
Pharmacology and toxicology
Hongogen and miconazole are antimycotics belonging to the group of imidazole derivatives. These agents inhibit the ergosterol biosynthesis, thereby causing disturbances in the permeability and function of the cell membrane. Systemic absorption of these agents is minimal. Hongogen is only used for the local treatment of mycosis of the skin and mucosa. In studies comparing intravaginal use of imidazoles to nystatin, imidazoles have superior cure rates and lower relapse rates. In a population-based study it was found that vulvovaginal clotrimoxazole treatment during pregnancy reduces the prevalence of preterm birth significantly ( Czeizel 2004A) .
Cons > embryotoxic potential of these topical antifungal agents ( King 1998 ). For miconazole these findings were confirmed in a population-based case control study ( Czeizel 2004B) .
Hongogen and miconazole are topical antimycotics of choice in pregnancy.