Grisovin tablets


  • Active Ingredient: Griseofulvin
  • 250 mg, 125 mg
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What is Grisovin?

The active ingredient of Grisovin brand is griseofulvin. Griseofulvin is an antifungal medication that fights infections caused by fungus. C17H17ClO6 M.W. 352.77 Griseofulvin, USP occurs as a white to creamy white, odorless powder which is very slightly soluble in water, soluble in acetone, dimethylformamide, and chloroform and sparingly soluble in alcohol. Griseofulvin is a pink to orange colored, tutti-frutti flavored, uniform suspension. Each 5 mL of Griseofulvin suspension contains 125 mg of Griseofulvin, USP (microsize) and also contains the following inactive ingredients: artificial flavors, carboxymethyl cellulose sodium, dl-alpha-tocopherol, FD&C red #40, FD&C yellow #6, glycerin, hydrochloric acid, methylparaben, microcrystalline cellulose, propylene glycol, propylparaben, simethicone emulsion, sodium alginate, sodium hydroxide, sodium lauryl sulfate and sucrose.

Used for

Grisovin is used to treat diseases such as: Dermatophytosis, Onychomycosis, Fingernail, Onychomycosis, Toenail, Tinea Barbae, Tinea Capitis, Tinea Corporis, Tinea Cruris, Tinea Pedis.

Side Effect

Possible side effects of Grisovin include: burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; nausea; diarrhea; unpleasant breath odor; dark urine.

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Grisovin side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

numbness, tingling, or burning pain in your hands or feet;

confusion, trouble with daily activities;

fever, chills, flu symptoms, white patches or sores inside your mouth or throat;

liver problems--loss of appetite, stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes);

kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath, foamy urine;

lupus-like symptoms--muscle or joint pain, flu symptoms, chest pain, and a rash or patchy skin color that worsens in sunlight; or

signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

sleep problems (insomnia); or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What Other Drugs Interact with Grisovin?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Grisovin has no known severe interactions with other drugs.

Grisovin has serious interactions with 21 different drugs.

Grisovin has moderate interactions with 112 different drugs.

Grisovin has minor interactions with 71 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

What is Grisovin tablet, and how does it work (mechanism of action)?

Grisovin is an oral antibiotic that is used to treat fungal infections of the skin, body, hair/beard, or nails. Grisovin prevents fungal cells from dividing and multiplying. Grisovin also is deposited in keratin cells on the surface of the skin making it difficult for fungus to invade the skin and other tissues. Grisovin is effective against Microsporum, Epidermophyton and Trichophyton. It is not effective against bacteria. The FDA approved Grisovin in 1959.

How to store Grisovin

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.
  • Serious skin reactions warning: This drug can cause skin reactions. These may be serious and life-threatening. Symptoms can include hives, fever, swelling of your tongue and face, and peeling or blistering of your skin. If you have signs of a skin reaction, stop taking the drug and call your doctor right away.
  • Liver damage warning: This drug can cause serious liver damage. This effect is more likely if you use the drug at high doses or for long periods of time. Symptoms can include bruising that happens easily, tiredness, weakness, stomach pain, lack of appetite, and yellowing of your skin or the whites of your eyes.
  • Pregnancy warning: You should not take this drug during pregnancy. There have been two cases of conjoined twins in women who took this drug during pregnancy. Women should use effective birth control during treatment with this drug. Men shouldn’t get a woman pregnant during treatment with this drug. Men should use birth control during treatment and for 6 months after stopping treatment with this drug.

Grisovin oral tablet is a prescription drug that’s available as the brand name drug Gris-PEG. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.

Grisovin also comes as an oral liquid suspension.

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Grisovin is also available from pharmacies as an over-the-counter skin spray. This product is sprayed directly on to the skin for the treatment of athlete's foot. If using this product follow the pharmacist's advice and refer to the manufacturer's leaflet provided with the medicine.

The rest of this leaflet is about taking Grisovin by mouth as a tablet or oral liquid medicine.

Grisovin Dosage

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

To make swallowing easier, you may crush the Gris-PEG tablet and sprinkle the medicine into a spoonful of applesauce. Swallow right away without chewing. Do not save the mixture for later use.

Use this medicine for the full prescribed length of time. It may take up several weeks before your symptoms improve. Nail infections can take several months to clear completely.

Grisovin will not treat a bacterial or fungal infection, or a viral infection such as the flu or a common cold.

If you use this medicine long-term, you may need frequent medical tests at your doctor's office.

Store at room temperature away from moisture, heat, and light.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Copyright 1996-2019 Cerner Multum, Inc.

Latest Update: 11/9/2018, Version: 6.01

What Is Grisovin?

Grisovin is an antifungal medication that fights infections caused by fungus.

Grisovin is used to treat infections such as ringworm, athlete's foot, jock itch, and fungal infections of the scalp, fingernails, or toenails.

Grisovin may also be used for purposes not listed in this medication guide.

You should not use Grisovin if you have porphyria or liver failure.

Taking Grisovin during the first 3 months of pregnancy may harm the unborn baby.

You should not use Grisovin if you are allergic to it, or if you have:

  • liver failure;
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); or
  • if you are pregnant or may become pregnant.

To make sure Grisovin is safe for you, tell your doctor if you have:

  • liver disease;
  • lupus;
  • an allergy to penicillin; or
  • if you take a blood thinner such as warfarin (Coumadin, Jantoven).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not use Grisovin if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Grisovin may make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking Grisovin.

It is not known whether Grisovin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Grisovin should not be given to a child younger than 2 years old, or a child who weighs less than 35 pounds.

Drug interactions

Grisovin can interact with other medications.

Antacids and H2 antagonists should not be taken for 2 hours after Grisovin because they might otherwise stop its absorption.

Grisovin interacts with alcohol rather like disulfiram (Antabuse) and can cause severe nausea and vomiting.

Grisovin can cause an increase in a liver enzyme reducing the concentration of:

  • Warfarin (thinning the blood less than required)
  • Oral contraceptive (increasing the chance of pregnancy)

Before taking Grisovin

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Grisovin it is important that your doctor knows:

  • If you are pregnant, trying for a baby, or breast-feeding.
  • If you have problems with the way your liver works.
  • If you have an inflammatory condition called systemic lupus erythematosus (SLE). Grisovin can make this condition worse.
  • If you have a rare inherited blood disorder called porphyria.
  • If you have ever had an allergic reaction to a medicine.
  • If you, or your partner, are using hormonal methods of contraception ('the pill').
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

Why is this medication prescribed?

Grisovin is used to treat skin infections such as jock itch, athlete's foot, and ringworm; and fungal infections of the scalp, fingernails, and toenails.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

home drugs a-z list Gris Peg(Grisovin) side effects drug center

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Gris-PEG (Grisovin ultramicrosize) is an antifungal medication used to treat fungal infections of the skin, hair, and nails such as jock itch, athlete's foot, and barber's itch. Common side effects of Gris-PEG include:

  • headache,
  • nausea,
  • vomiting,
  • diarrhea,
  • stomach upset,
  • tiredness,
  • dizziness,
  • trouble sleeping (insomnia),
  • flushing (warmth, redness, or tingly feeling),
  • confusion,
  • numbness or tingling in your hands or feet, or
  • menstrual irregularities.

Tell your doctor if you have unlikely but serious side effects of Gris-PEG including:

  • mental/mood changes (e.g., confusion, trouble doing normal activities),
  • sunburn-like rash,
  • hearing changes,
  • butterfly-shaped facial rash (around the nose and cheeks), or
  • joint or muscle pain.

Dosage of Gris-PEG varies. In adults a daily administration of 375–750 mg (as a single dose or in divided doses) is recommended. Dose depends on the condition being treated. The pediatric dose for children over 2 years of age is approximately 3.3 mg per pound of body weight per day. Gris-PEG may interact with oral anticoagulants (blood thinners), birth control pills, salicylates such as aspirin and others, and cyclosporine. Tell your doctor all medications you are taking. Gris-PEG is not recommended for use during pregnancy. It may harm a fetus. Use of birth control is recommended during treatment and for 1 month after the drug is stopped. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Gris-PEG (Grisovin ultramicrosize) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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