Author: Hon A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand , 2003.
Griseovet has been available since 1958 to treat ringworm (tinea). It is not effective against yeasts such as candida or malassezia.
Griseovet has been withdrawn from the market in New Zealand (2002) and other countries, as it has been superceded by more effective and safer antifungal drugs.
Griseovet comes from the mould, Penicillium griseofulvum. It stops fungal cells dividing (i.e. it is fungistatic) but does not kill them outright. This means treatment needs to be continued for several weeks or months. For many fungal infections, especially of the nail (tinea unguium), newer drugs work better than Griseovet.
Griseovet may still be preferable for tinea capitis, especially when due to Microsporum canis infection , and is generally well tolerated in children.
Griseovet tablets are not very well absorbed from the gut. They should be taken after a meal or drink of milk as fat increases the absorption. The medication is carried into the skin by sweat and within a couple of weeks is concentrated in the outer skin layers.
Half the medication is cleared from the blood stream in 10 to 20 hours; the rest is eliminated in urine and faeces. This means the medication can be taken once daily. Griseovet should be continued until the fungal infection has completely gone because the medication is quickly cleared from skin and hair when it is stopped.
Interactions that can make your drugs less effective
When certain drugs are used with Griseovet, these other drugs may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:
- Warfarin: Your doctor may increase your dosage of warfarin while you’re taking Griseovet.
- Birth control pills: Your doctor may have you use a second form of birth control that works better. You should not get pregnant during your treatment with this drug.
- Cyclosporine: Your doctor may increase your dosage of cyclosporine while you’re taking Griseovet.
- Salicylates such as aspirin and magnesium salicylate
When you take Griseovet with certain drugs, Griseovet may not work as well to treat your condition. This is because the amount of Griseovet in your body may be decreased. Examples of these drugs include:
- Barbiturates such as phenobarbital and butabarbital: Your doctor may increase your dosage of Griseovet.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Griseovet oral tablet comes with several warnings.
Michael Stewart, Reviewed by Prof Cathy Jackson | Last edited 11 Jan 2017 | Certified by The Information Standard
Griseovet is prescribed to treat fungal infections.
A course of treatment may last from a few weeks to several months.
Griseovet may harm an unborn child - you must avoid getting pregnant or fathering a child.
The most common side-effects are feeling sick (nausea) and diarrhoea.
Griseovet is a systemic antifungal agent effective against the common dermatophytes. It is practically insoluble in water and only slightly soluble in most organic solvents. Particle sizes of Griseovet vary from 2.7 μm (ultramicrosized) to 10 μm (microsized).
What are the side effects of Griseovet tablet?
Reported side effects include:
- Hypersensitivity type reactions including rashes, itching, and redness
- Angioedema (swelling under the surface of the skin)
- Numbness of the hands and feet
- Oral thrush (fungal infection with Candida Albicans)
- Upset stomach
- Loose stool (diarrhea)
- Difficulty sleeping (insomnia)
- Mental confusion
- Impairment of performance of routine activities
- Presence of abnormal quantities of protein in the urine (proteinuria)
- Reduced white blood cell count (leukopenia)
Biotransformation and Pharmacokinetics:
Depending on the species, 10%–50% of a Griseovet dose is excreted almost exclusively as metabolites in the urine, and the remainder in the feces for
4–5 days after administration. The elimination half-life of Griseovet is
24 hr in several species. The drug can be detected in 48–72 hr at the base level of the skin, in 6–12 days in the lower quarter, and in 2–19 days in the middle section of the horny layer.
More common side effects
The more common side effects of Griseovet can include:
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.