Warnings for other groups
For pregnant women: Grifulin is a category X pregnancy drug. Category X drugs should never be used during pregnancy. Women who are pregnant should not take any form of Grifulin.
Men taking this drug should not get a woman pregnant. Call your doctor right away if you become pregnant or get a woman pregnant while taking this drug. Men should use reliable birth control during treatment and for 6 months after stopping treatment with this drug. Women of childbearing age should use reliable birth control throughout treatment with this drug.
For women who are breastfeeding: Grifulin may pass into breast milk and cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
For children: This drug has not been established as safe and effective in children 2 years of age and younger. In addition, safety has not been established in children older than 2 years of age at dosages greater than 10 mg/kg daily.
This dosage information is for Grifulin oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
More common side effects
The more common side effects of Grifulin can include:
- numbness or tingling in your hands or feet
- yeast infections in your mouth
- stomach pain
- trouble sleeping
If these effects are mild, they may go away within a few days or a couple of weeks. If they're more severe or don't go away, talk to your doctor or pharmacist.
How should this medicine be used?
Grifulin comes as a tablet, capsule, and liquid to take by mouth. It is usually taken once a day or can be taken two to four times a day. Although your symptoms may get better in a few days, you will have to take Grifulin for a long time before the infection is completely gone. It is usually taken for 2 to 4 weeks for skin infections, 4 to 6 weeks for hair and scalp infections, 4 to 8 weeks for foot infections, 3 to 4 months for fingernail infections, and at least 6 months for toenail infections. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Grifulin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the liquid well before each use to mix the medication evenly.
Continue to take Grifulin even if you feel well. Do not stop taking Grifulin without talking to your doctor.
- Hepatocellular failure
Effects of Drug Abuse
- See "What Are Side Effects Associated with Using Grifulin?"
- See "What Are Side Effects Associated with Using Grifulin?"
- Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) and erythema multiforme reported, some resulting in hospitalization or death; discontinue if severe skin reaction occurs.
- Elevations in AST, ALT, bilirubin, and jaundice reported, some resulting in hospitalization or death; discontinue if jaundice occurs.
- Patients on prolonged therapy with any potent medication should be under close observation; periodic monitoring of organ system function, including renal, hepatic and hematopoietic, should be done.
- Do not use Grifulin during pregnancy. The risks involved outweigh potential benefits. Safer alternatives exist.
- It is unknown if Grifulin is excreted in breast milk; avoid use because of potential to cause tumors (tumorgenicity).
This medication contains Grifulin. Do not take Grifulvin V or Gris-PEG if you are allergic to Grifulin or any ingredients contained in this drug.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
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Grifulin is also available from pharmacies as an over-the-counter skin spray. This product is sprayed directly on to the skin for the treatment of athlete's foot. If using this product follow the pharmacist's advice and refer to the manufacturer's leaflet provided with the medicine.
The rest of this leaflet is about taking Grifulin by mouth as a tablet or oral liquid medicine.
Interactions that can make your drugs less effective
When certain drugs are used with Grifulin, these other drugs may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:
- Warfarin: Your doctor may increase your dosage of warfarin while you're taking Grifulin.
- Birth control pills: Your doctor may have you use a second form of birth control that works better. You should not get pregnant during your treatment with this drug.
- Cyclosporine: Your doctor may increase your dosage of cyclosporine while you're taking Grifulin.
- Salicylates such as aspirin and magnesium salicylate
When you take Grifulin with certain drugs, Grifulin may not work as well to treat your condition. This is because the amount of Grifulin in your body may be decreased. Examples of these drugs include:
- Barbiturates such as phenobarbital and butabarbital: Your doctor may increase your dosage of Grifulin.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Grifulin oral tablet comes with several warnings.
What is Grifulin tablet, and how does it work (mechanism of action)?
Grifulin is an oral antibiotic that is used to treat fungal infections of the skin, body, hair/beard, or nails. Grifulin prevents fungal cells from dividing and multiplying. Grifulin also is deposited in keratin cells on the surface of the skin making it difficult for fungus to invade the skin and other tissues. Grifulin is effective against Microsporum, Epidermophyton and Trichophyton. It is not effective against bacteria. The FDA approved Grifulin in 1959.
Grifulin is a medicine which is used to treat fungal infections. It is mainly prescribed for infections occurring on the skin or scalp. It is prescribed in particular for an infection called scalp ringworm (also called tinea capitis). It is also used to treat some nail infections, especially when other more frequently prescribed treatments are not suitable for some reason.
Grifulin is active against Microsporum, Epidermophyton, and Trichophyton spp. It has no effect on bacteria (including Actinomyces and Nocardia spp), other fungi, or yeasts.
Grifulin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach
- diarrhea or loose stools
What Is Grifulin?
Grifulin is an antifungal medication that fights infections caused by fungus.
Grifulin is used to treat infections such as ringworm, athlete's foot, jock itch, and fungal infections of the scalp, fingernails, or toenails.
Grifulin may also be used for purposes not listed in this medication guide.
You should not use Grifulin if you have porphyria or liver failure.
Taking Grifulin during the first 3 months of pregnancy may harm the unborn baby.
You should not use Grifulin if you are allergic to it, or if you have:
- liver failure;
- porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); or
- if you are pregnant or may become pregnant.
To make sure Grifulin is safe for you, tell your doctor if you have:
- liver disease;
- an allergy to penicillin; or
- if you take a blood thinner such as warfarin (Coumadin, Jantoven).
FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not use Grifulin if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Grifulin may make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy while taking Grifulin.
It is not known whether Grifulin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Grifulin should not be given to a child younger than 2 years old, or a child who weighs less than 35 pounds.
- Serious skin reactions warning: This drug can cause skin reactions. These may be serious and life-threatening. Symptoms can include hives, fever, swelling of your tongue and face, and peeling or blistering of your skin. If you have signs of a skin reaction, stop taking the drug and call your doctor right away.
- Liver damage warning: This drug can cause serious liver damage. This effect is more likely if you use the drug at high doses or for long periods of time. Symptoms can include bruising that happens easily, tiredness, weakness, stomach pain, lack of appetite, and yellowing of your skin or the whites of your eyes.
- Pregnancy warning: You should not take this drug during pregnancy. There have been two cases of conjoined twins in women who took this drug during pregnancy. Women should use effective birth control during treatment with this drug. Men shouldn’t get a woman pregnant during treatment with this drug. Men should use birth control during treatment and for 6 months after stopping treatment with this drug.
Grifulin oral tablet is a prescription drug that’s available as the brand name drug Gris-PEG. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug.
Grifulin also comes as an oral liquid suspension.