FDA Box Warning
• Oral form has been linked to hepatic toxicity, including some deaths. Inform patient of this risk, and monitor closely.
• Concurrent use of astemizole, cisapride, or terfenadine with Fungoral tablets is contraindicated, because serious cardiovascular adverse events (including death, ventricular tachycardia, and torsades de pointes) have occurred.
Fungoral and DHT receptors
A further study looked into the possibility that it could treat androgenic alopecia too. Unlike dandruff and seborrheic dermatitis, androgenic alopecia involves hair loss as a result of producing too many DHT receptors. It’s usually a genetic condition, which causes the hair loss we see with male pattern baldness.
Those who suffer from androgenic alopecia experience some physiological processes:
- The hair follicles shrink in size
- Their hair follicles spend less time in the anagen phase of hair growth, which is where it grows long and thick.
- Instead, they spend more time in the telogen phase of hair growth, which is where the follicles remain dormant.
- Because of this, the terminal to vellus hair ratio drops. Terminal hair is the hair that’s thick and strong, whereas vellus is thin and wispy.
For reasons we don’t understand, the terminal to vellus hair ratio will then increase in other areas of the body. One study from Japan found that those who have androgenic alopecia also have higher lipid profiles. When we have high lipid profiles, we’re even more likely to encounter harmful inflammatory processes that don’t allow cells to thrive or heal. As high serum lipid concentrations have a connection with increased inflammatory markers, it’s clear our hair follicles need all the help they can get.
Interactions that increase your risk of side effects
Taking certain drugs with Fungoral raises your risk of side effects.
- Side effects from Fungoral: Taking Fungoral with certain medications raises your risk of side effects from Fungoral. This is because the amount of Fungoral in your body is increased. Examples of these drugs include:
- Pain drugs, such as buprenorphine, fentanyl, and oxycodone. Taking these drugs with Fungoral may cause slowed breathing.
- Anticoagulants, such as rivaroxaban, dabigatran, and warfarin. Taking these drugs with Fungoral may increase your risk of bleeding.
- Heart drugs, such as felodipine and nisoldipine. Taking these drugs with Fungoral may cause swelling of your legs or arms and heart failure.
- Tamsulosin. Taking these drugs together may cause headache, dizziness, and orthostatic hypotension (low blood pressure when you stand up from a sitting or lying position).
- Digoxin. Taking these drugs together may cause dizziness, headache, and stomach pain. Your doctor may monitor your digoxin blood levels.
- Eletriptan. Taking these drugs together may cause weakness, nausea, dizziness, and drowsiness.
- Antipsychotic drugs, such as aripiprazole, buspirone, haloperidol, quetiapine, and risperidone. Taking these drugs with Fungoral may cause dizziness, drowsiness, and headaches.
- Ramelteon. Taking these drugs together may cause dizziness, drowsiness, and fatigue.
- Antivirals such as indinavir, maraviroc, and saquinavir. Taking these drugs with Fungoral may cause stomach pain, nausea, and headaches.
- Blood pressure drugs, such as verapamil and aliskiren.Taking these drugs with Fungoral may cause low blood pressure, low heart rate, and dizziness.
- Drugs for erectile dysfunction, such as sildenafil, tadalafil, and vardenafil. Taking these drugs with Fungoral may cause headaches, upset stomach, and muscle pain.
- Drugs for urine problems, such as solifenacin and tolterodine. Taking these drugs with Fungoral may cause dry mouth, headaches, and dizziness.
What is Fungoral?
Fungoral is an im >enzymes and stops the cells making ergosterol, the main component of the cell wall. In New Zealand, it is available as shampoo and cream .
Fungoral is effective against a broad spectrum of fungi including:
Fungoral 2% Cream (Nizoral Cream®) daily and 2% Shampoo (Nizoral®, Sebizole®) twice weekly are used for seborrhoeic dermatitis , a common scaly rash affecting scalp and face. They are subs >over the counter at a chemist. Topical Fungoral is safe.
Where can I get more information?
Your pharmacist can provide more information about Fungoral topical.
Before using Fungoral,
- tell your doctor and pharmacist if you are allergic to Fungoral or any other medications, creams, or shampoos. If you will be using the cream, tell your doctor if you are allergic to sulfites.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had any medical condition. If you will be using the cream, tell your doctor if you have or have ever had asthma.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using Fungoral, call your doctor.
Generic Name: Fungoral (KEE toe KON a zole)Brand Name: Nizoral
Medically reviewed by Drugs.com on Jan 10, 2019 – Written by Cerner Multum
• Apply cream to damp skin of affected area and wide surrounding area.
• To use shampoo, wet hair, then apply shampoo and massage into scalp for 1 minute. Leave on for 5 minutes before rinsing. Rinse and repeat, this time leaving shampoo on scalp for 3 minutes before rinsing.
• Don't apply shampoo to broken or inflamed skin.
• In achlorhydria, dissolve 200-mg tablet in 4 ml of 0.2N hydrochloric acid solution.
• Withhold antacids for at least 2 hours after giving oral Fungoral.
☞ Don't give concurrently with cisapride, available in U.S. for compassionate use only. (Astemizole and terfenadine are not available in U.S.)
How to Use a Fungoral Shampoo for Hair Loss
There are 1% over-the-counter and 2% prescription Fungoral solutions available. The 1% solutions are entirely sufficient for hair loss prevention. To maximize the benefit to your hair, you will want to use the shampoo once every three days (or twice a week on scheduled days) whatever is easiest for you to remember and create a habit for yourself.
- Apply the shampoo once as soon as you get into the shower and create a lather and massage into your hair and scalp for 1 minute.
- Rinse thoroughly and repeat, then leave the lather on for a minimum of an additional 3 minutes.
- Rinse off completely.
What is Fungoral?
Fungoral is a prescription medication that is primarily used to treat fungal infections. Technically, it has been classified pharmacologically as an antifungal drug.
It works by managing different forms of fungal infections such as ringworm, candidiasis, and seborrheic dermatitis, which are all more common amongst people than you’d think.
We did come to learn that treating fungal infections is not the only possible indication of using Fungoral. If you did not know already, Fungoral is a common ingredient that you will find in most hair loss shampoos.
Fungoral 2% cream (Nizoral Cream by Janssen, and others) is an antifungal medication used to treat various fungus and yeast infections. It is used for the topical (applied to the skin) treatment of tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athletes foot), and in the treatment of tinea (pityriasis) versicolor ("sun fungus"); it is also used in the treatment of some skin yeast infections and in the treatment of seborrheic dermatitis.
Fungoral 2% cream is the generic name, is in the class of azole antifungals, and is only available with a prescription from your doctor.
In addition to killing fungi, Fungoral is also helpful in countering the effects of dihydrotestosterone in people who have androgenetic alopecia 1. A study by J. Jiang and published in the April 2005 edition of the "Journal of Dermatology" found that topical application of 2 percent Fungoral shampoo in mice stimulated hair growth 3.