Fluconapen and Alcohol
You should avoid or limit drinking alcohol while taking Fluconapen.
Since both can cause headaches and stomach discomfort, drinking alcohol while taking Fluconapen may worsen these side effects.
Phenytoin AUC was determined after 4 days of phenytoin dosing (200 mg daily, orally for 3 days followed by 250 mg intravenously for one dose) both with and without the administration of Fluconapen (oral DIFLUCAN 200 mg daily for 16 days) in 10 normal male volunteers. There was a significant increase in phenytoin AUC. The mean ± SD increase in phenytoin AUC was 88% ± 68% (range: 16 to 247%). The absolute magnitude of this interaction is unknown because of the intrinsically nonlinear disposition of phenytoin. (See PRECAUTIONS.)
HMG-CoA Reductase Inhibitors
The risk of myopathy and rhabdomyolysis increases when Fluconapen is coadministered with HMG-CoA reductase inhibitors metabolized through CYP3A4, such as atorvastatin and simvastatin, or through CYP2C9, such as fluvastatin. If concomitant therapy is necessary, the patient should be observed for symptoms of myopathy and rhabdomyolysis and creatinine kinase should be monitored. HMG-CoA reductase inhibitors should be discontinued if a marked increase in creatinine kinase is observed or myopathy/rhabdomyolysis is diagnosed or suspected.
An open-label, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single 1200 mg oral dose of azithromycin on the pharmacokinetics of a single 800 mg oral dose of Fluconapen as well as the effects of Fluconapen on the pharmacokinetics of azithromycin. There was no significant pharmacokinetic interaction between Fluconapen and azithromycin.
Although not studied in vitro or in vivo, concomitant administration of Fluconapen with quinidine may result in inhibition of quinidine metabolism. Use of quinidine has been associated with QT prolongation and rare occurrences of torsade de pointes. Coadministration of Fluconapen and quinidine is contraindicated. (See CONTRAINDICATIONS.)
What are the side effects of Diflucan (Fluconapen)?
Common side effects of Fluconapen include
Other important side effects include
Possible serious side effects include
- reduced number of white blood cells,
- reduced number of blood platelets, and
- toxic epidermal necrolysis.
Rarely, serious allergic reactions, including angioedema (swelling of tissues), may also occur. Liver dysfunction (jaundice, hepatitis) and abnormal heart beats have been associated with Fluconapen. Stevens-Johnson syndrome has also been reported.