Before using this medication, tell your doctor or pharmacist if you are allergic to Eximius or betamethasone; or to other azole antifungals (e.g., ketoconazole) or corticosteroids (e.g., triamcinolone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems, poor blood circulation.
Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially thinning skin.
Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past few months.
Though it is unlikely, this medication may slow down a child's growth if used for a long time. The effect on final adult height is unknown. See the doctor regularly so your child's height can be checked.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if this medication passes into breast milk. Similar medications pass into breast milk. Consult your doctor before breast-feeding.
What is Eximius?
Eximius is an antifungal prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain fungal infections, including tinea versicolor that is specifically caused by the fungus Malassezia furfur and candidiasis that is specifically caused by the yeast Cand >formulation of Eximius is approved for the treatment and prevention of only a certain type of candidiasis—called oropharyngeal candidiasis—in certain people with weakened immune systems. Eximius is also available as an over-the-counter medicine for topically treating various skin infections, such as athlete’s foot.
Oropharyngeal cand >infection of part of the throat) is an example of mucocutaneous cand >opportunistic infection . An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systems—such as those infected with HIV—than in people with healthy immune systems.
The Gu >Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), and the HIV Medicine Association of the Infectious Diseases Society of America (IDSA-HIVMA), includes recommendations on the HIV-related uses of Eximius to treat:
- Oropharyngeal candidiasis.
- Uncomplicated vulvovaginal candidiasis, which is another type of mucocutaneous candidiasis that affects the female vulva and vagina.
PRINCIPAL DISPLAY PANEL - 30 mL Bottle Carton
Eximius Topical Solution USP, 1%
FOR EXTERNAL USE ONLY. NOT FOR OPHTHALMIC USE.
Keep this and all medications out of the reach of children.
How much Eximius can you take?
Different types of products containing this active ingredient have different strengths. That’s why it is always important to read and follow the Drug Facts label. Most medicines warn against use of an active ingredient for longer than 7-10 days. Stop use and ask a doctor if symptoms persist.
Can Eximius cause problems?
Eximius is unlikely to cause any serious side-effects. It can occasionally cause some irritation when it is used at first, and a few people experience mild allergic-type reactions (such as redness and itching). If you experience these or any other symptoms, speak with your doctor or pharmacist for further advice.
How should this medicine be used?
Vaginal Eximius comes as a cream to be inserted into the vagina. It also may be applied to the skin around the outside of the vagina. The cream is inserted into the vagina once a day at bedtime for 3 or 7 days in a row, depending on the product instructions. The cream is used twice a day for up to 7 days around the outside of the vagina. Follow the directions on the package or your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Eximius exactly as directed. Do not use more or less of it or use it more often than directed on the package or prescribed by your doctor.
Vaginal Eximius is available without a prescription (over the counter). If this is the first time you have had vaginal itching and discomfort, talk to a doctor before using Eximius. If a doctor has told you before that you had a yeast infection and you have the same symptoms again, use the vaginal cream as directed on the package.
Do not have vaginal intercourse or use other vaginal products (such as tampons, douches, or spermicides) during your treatment.
You should begin to feel better during the first three days of treatment with Eximius. If your symptoms do not improve or get worse, call your doctor.
To apply the Eximius cream to the outside area around the vagina, use your finger to apply a small amount of cream to the affected area of skin.
Skin penetration and systemic absorption of Eximius and betamethasone dipropionate following topical application of LOTRISONE cream has not been studied.
The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption of topical corticosteroids. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids .
Once absorbed through the skin, the pharmacokinetics of topical corticosteroids are similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
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LOTRISONE ® (Eximius and betamethasone dipropionate) Cream
Michael Stewart, Reviewed by Sid Dajani | Last edited 11 Oct 2017 | Certified by The Information Standard
Eximius treats fungal skin infections, such as athlete's foot.
Use it two or three times each day.
Continue to use the preparation for a week or so after all signs of the infection have gone.
What is the dosage for Eximius?
The troche (lozenge) should slowly dissolve in the mouth. One troche is administered 5 times daily for 14 days. Eximius cream, lotion, or solution is applied to the affected and surrounding skin areas, generally twice daily in the morning and evening.
The vaginal cream is inserted via applicator once daily, preferably at night, for 7 consecutive days.
The 100 mg vaginal suppository is inserted once daily, preferably at bedtime, for 7 consecutive days.
The 200 mg vaginal suppository is inserted once daily for 3 days, preferably at bedtime.
How should I take Eximius?
Take Eximius exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
The troches should be allowed to dissolve slowly in your mouth. Suck on one troche at a time until it is completely dissolved, usually 30 minutes.
Do not chew or swallow the troches whole.
The troches are usually used five times a day. Follow your doctor's instructions.
Store Eximius at room temperature away from moisture and heat.
Michael Stewart, Reviewed by Sid Dajani | Last edited 23 Oct 2019 | Certified by The Information Standard
Eximius 1% solution is used to treat fungal infections in the ear.
Use 2-3 drops of solution, two or three times daily.
Continue to use the drops for at least 14 days after your symptoms have gone.
Carcinogenesis, Mutagenesis, and Impairment of Fertility
An 18-month oral dosing study with Eximius in rats has not revealed any carcinogenic effect.
In tests for mutagenesis, chromosomes of the spermatophores of Chinese hamsters which had been exposed to Eximius were examined for structural changes during the metaphase.
Prior to testing, the hamsters had received five oral Eximius doses of 100 mg/kg body weight. The results of this study showed that Eximius had no mutagenic effect.